Drug development in Alzheimer’s disease: the path to 2025

Big data to smart data in Alzheimer's disease: Real-world examples of advanced modeling and simulation

(2016) Magali Haas et al.   Alzheimers & Dementia

Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge

(2016) Hugo Geerts et al.   Alzheimers & Dementia

Challenges, solutions, and recommendations for Alzheimer's disease combination therapy

(2016) James A. Hendrix et al.   Alzheimers & Dementia

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials

(2016) Jinping Wang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Global Trends in Alzheimer Disease Clinical Development: Increasing the Probability of Success

(2015) Haruhiko Sugino et al.   CLINICAL THERAPEUTICS

A pivotal moment in Alzheimer’s disease and dementia: how global unity of purpose and action can beat the disease by 2025

(2015) George Vradenburg   Expert Review of Neurotherapeutics

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

(2015) Sandrine Andrieu et al.   LANCET NEUROLOGY

A pivotal moment in Alzheimer’s disease and dementia: how global unity of purpose and action can beat the disease by 2025

(2015) George Vradenburg   Expert Review of Neurotherapeutics

The future is now: Model-based clinical trial design for Alzheimer's disease

(2015) K Romero et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

THE ALZHEIMER'S PREVENTION INITIATIVE

(2014) Pierre N. Tariot et al.   Alzheimers & Dementia

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers

(2014) Qing Liu et al.   JAMA Neurology

The Preclinical Alzheimer Cognitive Composite

(2014) Michael C. Donohue et al.   JAMA Neurology

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges

(2014) Jeffrey L Cummings et al.   Expert Review of Clinical Pharmacology

Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications

(2013) Brian Appleby et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Review: Treatment of Alzheimer’s Disease Discovered in Repurposed Agents

(2013) Brian S. Appleby et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cognitive Declines Precede and Predict Functional Declines in Aging and Alzheimer’s Disease

(2013) Laura B. Zahodne et al.   PLoS One

Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease

(2012) M. Wagner et al.   NEUROLOGY

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Current Alzheimer's disease clinical trials: Methods and placebo outcomes

(2009) Lon S. Schneider et al.   Alzheimers & Dementia

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment

(2009) Johannes Kornhuber et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS