Lactate in the brain: from metabolic end-product to signalling molecule

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na+ /K+ -ATPase coupled to endothelin receptor type B stimulates peripheral nerve regeneration via lactate signalling

(2017) Nguyen H. Tu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism

(2017) Alejandro San Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

(2017) Lotti M. Supplie et al.   JOURNAL OF NEUROSCIENCE

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

[18F]FDG PET signal is driven by astroglial glutamate transport

(2017) Eduardo R Zimmer et al.   NATURE NEUROSCIENCE

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

(2017) Jerome Clasadonte et al.   NEURON

Astrocytic control of synaptic function

(2017) Thomas Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Astroglial Versus Neuronal D-Serine: Check Your Controls!

(2017) Herman Wolosker et al.   TRENDS IN NEUROSCIENCES

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Astrocytic l -Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats

(2017) Jun Wang et al.   Cell Reports

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

(2017) Leslie Mazuel et al.   PLoS One

Cytosolic NADH-NAD+ Redox Visualized in Brain Slices by Two-Photon Fluorescence Lifetime Biosensor Imaging

(2016) Rebecca Mongeon et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

(2016) Yan Zhang et al.   BIOLOGICAL PSYCHIATRY

A Role for Lactate in the Consolidation of Drug-Related Associative Memories

(2016) Benjamin Boutrel et al.   BIOLOGICAL PSYCHIATRY

Locus coeruleus: From global projection system to adaptive regulation of behavior

(2016) G. Aston-Jones et al.   BRAIN RESEARCH

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients

(2016) Gerald A Dienel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward

(2016) Kavya Devarakonda et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Regulation of neuron–astrocyte metabolic coupling across the sleep–wake cycle

(2016) J.-M. Petit et al.   NEUROSCIENCE

Sodium sensing in the subfornical organ and body-fluid homeostasis

(2016) Takeshi Y. Hiyama et al.   NEUROSCIENCE RESEARCH

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

(2016) P. Jourdain et al.   Scientific Reports

Consolidating Memories

(2015) James L. McGaugh   Annual Review of Psychology

Glial Glycolysis Is Essential for Neuronal Survival in Drosophila

(2015) Anne Volkenhoff et al.   Cell Metabolism

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

(2015) Brett M. Morrison et al.   EXPERIMENTAL NEUROLOGY

Hemichannel-mediated release of lactate

(2015) Anastassios Karagiannis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Is L-Lactate a Novel Signaling Molecule in the Brain?

(2015) Valentina Mosienko et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

(2015) Corrado Calì et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Effects of Acute Aerobic Exercise on the Primary Motor Cortex

(2015) Amaya M. Singh et al.   JOURNAL OF MOTOR BEHAVIOR

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

(2015) Cecilie Morland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine

(2015) B Boury-Jamot et al.   MOLECULAR PSYCHIATRY

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

(2015) Rodrigo Lerchundi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

(2015) Maha Elsayed et al.   Frontiers in Cellular Neuroscience

The Astrocyte: Powerhouse and Recycling Center

(2015) Bruno Weber et al.   Cold Spring Harbor Perspectives in Biology

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Acid–base dysregulation and chemosensory mechanisms in panic disorder: a translational update

(2015) L L Vollmer et al.   Translational Psychiatry

Glycolysis and the significance of lactate in traumatic brain injury

(2015) Keri L. H. Carpenter et al.   Frontiers in Neuroscience

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory

(2015) Monika Tadi et al.   PLoS One

Communication breakdown: The impact of ageing on synapse structure

(2014) Ronald S. Petralia et al.   AGEING RESEARCH REVIEWS

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

(2014) Piotr Mamczur et al.   GLIA

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease

(2014) J. Duran et al.   HUMAN MOLECULAR GENETICS

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

(2014) Pierre Bouzat et al.   INTENSIVE CARE MEDICINE

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission

(2014) M. Nagase et al.   JOURNAL OF NEUROSCIENCE

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Cerebral glycolysis: a century of persistent misunderstanding and misconception

(2014) Avital Schurr   Frontiers in Neuroscience

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial

(2013) Carole Ichai et al.   INTENSIVE CARE MEDICINE

Cerebral Extracellular Lactate Increase is Predominantly Nonischemic in Patients with Severe Traumatic Brain Injury

(2013) Nathalie Sala et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices

(2012) P. Jakoby et al.   CEREBRAL CORTEX

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

(2012) Carole Berthet et al.   CEREBROVASCULAR DISEASES

Deleterious effects of neuronal accumulation of glycogen in flies and mice

(2012) Jordi Duran et al.   EMBO Molecular Medicine

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications

(2012) Woong Hee Kim et al.   SENSORS

Memory modulation.

(2011) Benno Roozendaal et al.   BEHAVIORAL NEUROSCIENCE

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

(2011) C. X. Bittner et al.   JOURNAL OF NEUROSCIENCE

NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+

(2011) I. Ruminot et al.   JOURNAL OF NEUROSCIENCE

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal

(2010) M. P. Parsons et al.   JOURNAL OF NEUROSCIENCE

Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

(2010) F. Boumezbeur et al.   JOURNAL OF NEUROSCIENCE

Changes in Central Sodium and not Osmolarity or Lactate Induce Panic-Like Responses in a Model of Panic Disorder

(2010) Andre I Molosh et al.   NEUROPSYCHOPHARMACOLOGY

Elevated blood lactate is associated with increased motor cortex excitability

(2010) Marinella Coco et al.   SOMATOSENSORY AND MOTOR RESEARCH

Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis

(2010) Yuri Zilberter et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study

(2009) Clare N. Gallagher et al.   BRAIN

Glucose and lactate supply to the synapse

(2009) L. Felipe Barros et al.   BRAIN RESEARCH REVIEWS

The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior

(2009) Adam E. Ziemann et al.   CELL

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

(2008) Joy L. Kovar et al.   ANALYTICAL BIOCHEMISTRY

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: A multiphoton study of cerebellar slices

(2008) L.F. Barros et al.   GLIA

Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte-Neuron Lactate-Shuttle Hypothesis

(2008) J. S. Erlichman et al.   JOURNAL OF NEUROSCIENCE

Lactate Stimulates Vasculogenic Stem Cells via the Thioredoxin System and Engages an Autocrine Activation Loop Involving Hypoxia-Inducible Factor 1

(2008) T. N. Milovanova et al.   MOLECULAR AND CELLULAR BIOLOGY

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE