Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Abeta DNA Vaccination for Alzheimers Disease: Focus on Disease Prevention

(2012) David H. Cribbs   CNS & Neurological Disorders-Drug Targets

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimers Disease Pathology

(2011) J. J.M. Hoozemans et al.   CNS & Neurological Disorders-Drug Targets

Complement activation as a biomarker for Alzheimer's disease

(2011) Mohammed Aiyaz et al.   IMMUNOBIOLOGY

Toll-like receptors are key players in neurodegeneration

(2011) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

NLR functions beyond pathogen recognition

(2011) Thomas A Kufer et al.   NATURE IMMUNOLOGY

Predicting MCI outcome with clinically available MRI and CSF biomarkers

(2011) D. Heister et al.   NEUROLOGY

Inflammation-associated S100 proteins: new mechanisms that regulate function

(2010) Jesse Goyette et al.   AMINO ACIDS

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

(2010) Vitaly Vasilevko et al.   Annals of the New York Academy of Sciences

Beclin 1 Complex in Autophagy and Alzheimer Disease

(2010) Philipp A. Jaeger et al.   ARCHIVES OF NEUROLOGY

S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis

(2010) Peter L. van Lent et al.   ARTHRITIS AND RHEUMATISM

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

NLRP3 has a sweet tooth

(2010) Beckley K Davis et al.   NATURE IMMUNOLOGY

Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology

(2010) A.C. Cuello et al.   Neurodegenerative Diseases

Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging

(2010) Osamu Abe et al.   NMR IN BIOMEDICINE

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

The Inflammatory Hypothesis of Alzheimer Disease: Dead or Alive?

(2009) Paul S. Aisen   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Alzheimer's Disease Anti-Inflammatory Prevention Trial: Design, methods, and baseline results

(2009)   Alzheimers & Dementia

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Age- and Gender-Related Differences in the Cortical Anatomical Network

(2009) G. Gong et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

A longitudinal study of gray matter volume decline with age and modifying factors

(2009) Yasuyuki Taki et al.   NEUROBIOLOGY OF AGING

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort

(2009) J.C.S. Breitner et al.   NEUROLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Involvement of Fc Receptors in Disorders of the Central Nervous System

(2009) Eitan Okun et al.   NEUROMOLECULAR MEDICINE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Endogenous signals initiating inflammation in the injured nervous system

(2008) Isabelle Pineau et al.   GLIA

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING