Application of Antibody Fragments Against Aβ With Emphasis on Combined Application With Nanoparticles in Alzheimer’s Disease

Progression of Alzheimer's disease and effect of scFv‐h3D6 immunotherapy in the 3xTg‐AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy

(2020) J. Güell‐Bosch et al.   NMR IN BIOMEDICINE

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

(2020) Jinbing Xie et al.   ACS Nano

Preparation and in vitro activity of single chain antibodies against Alzheimer's disease

(2020) Lu Fu et al.   IMMUNOLOGY LETTERS

Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with Aβ Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer’s Disease

(2020) Xiao-Ge Liu et al.   International Journal of Nanomedicine

Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice

(2020) Alejandro R. Roda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

(2020) Tapan Behl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer’s Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation

(2020) Alejandro R. Roda et al.   Pharmaceutics

Lessons Learnt from the Second Generation of Anti-Amyloid Monoclonal Antibodies Clinical Trials

(2020) Angela Tian Hui Kwan et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Antibody Fragments as Tools for Elucidating Structure-Toxicity Relationships and for Diagnostic/Therapeutic Targeting of Neurotoxic Amyloid Oligomers

(2020) André L. B. Bitencourt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanoconstructs as a versatile tool for detection and diagnosis of Alzheimer biomarkers

(2020) Divya Gopalan et al.   NANOTECHNOLOGY

Advancements in the Blood–Brain Barrier Penetrating Nanoplatforms for Brain Related Disease Diagnostics and Therapeutic Applications

(2020) Suresh Thangudu et al.   Polymers

Immunosensor incorporating half-antibody fragment for electrochemical monitoring of amyloid-β fibrils in artificial blood plasma

(2020) Gopal Palla et al.   BIOELECTROCHEMISTRY

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden

(2019) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment

(2019) Gisela Esquerda-Canals et al.   PLoS One

Construction of Quenchbodies to detect and image amyloid β oligomers

(2018) Jinhua Dong et al.   ANALYTICAL BIOCHEMISTRY

Anti-Amyloid-β Single-Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhages in an Alzheimer's Disease Mouse Model

(2018) Jinghong Kou et al.   JOURNAL OF ALZHEIMERS DISEASE

A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes

(2018) Mengming Hu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Mode of Action of an Anti-Oligomeric Amyloid β-Protein Antibody Affects its Protective Efficacy

(2018) Yunlong Zhang et al.   NEUROTOXICITY RESEARCH

Novel antibody against oligomeric amyloid-β: Insight into factors for effectively reducing the aggregation and cytotoxicity of amyloid-β aggregates

(2018) Xiaoning Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

(2017) Adriano Sebollela et al.   JOURNAL OF NEUROCHEMISTRY

Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv

(2017) Laia Montoliu-Gaya et al.   PROTEIN SCIENCE

Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease

(2017) Alfonso Martin-Peña et al.   Scientific Reports

Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect

(2017) Laia Montoliu-Gaya et al.   PLoS One

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets

(2016) Tengfei Li et al.   JOURNAL OF CONTROLLED RELEASE

Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities inDrosophilamodels of Alzheimer's disease

(2015) Pedro Fernandez-Funez et al.   HUMAN MOLECULAR GENETICS

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

(2015) Maarten Rotman et al.   JOURNAL OF CONTROLLED RELEASE

The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody

(2015) Yuan Zhang et al.   NEUROPHARMACOLOGY

Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake

(2015) Maarten Rotman et al.   NUCLEAR MEDICINE AND BIOLOGY

Single Chain Variable Fragment Against Aβ Expressed in Baculovirus Inhibits Abeta Fibril Elongation and Promotes its Disaggregation

(2015) Ying Zhang et al.   PLoS One

Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X

(2015) Gregory Antonios et al.   Scientific Reports

Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits

(2014) Edward K. Agyare et al.   JOURNAL OF CONTROLLED RELEASE

Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils

(2014) Yuan Zhang et al.   MOLECULAR NEUROBIOLOGY

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

(2013) Srinath Kasturirangan et al.   BIOTECHNOLOGY PROGRESS

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

(2013) Gisela Esquerda-Canals et al.   mAbs

Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease

(2013) Lydia Giménez-Llort et al.   mAbs

Characterization of a Single-Chain Variable Fragment Recognizing a Linear Epitope of Aβ: A Biotechnical Tool for Studies on Alzheimer’s Disease?

(2013) Silke Dornieden et al.   PLoS One

Central amyloid- -specific single chain variable fragment ameliorates A  aggregation and neurotoxicity

(2013) R. M. Nisbet et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineered antibody approaches for Alzheimer’s disease immunotherapy

(2012) Remy Robert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer’s Disease Mouse Model

(2012) Junling Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

(2011) Marta Marín-Argany et al.   BIOCHEMICAL JOURNAL

Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer’s disease

(2010) Yan-Jiang Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries

(2010) M. Medecigo et al.   JOURNAL OF NEUROIMMUNOLOGY

Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice

(2010) Deborah A Ryan et al.   MOLECULAR THERAPY

Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers

(2009) Xiao-ping Wang et al.   FEBS LETTERS

Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment

(2009) Remy Robert et al.   PROTEIN SCIENCE

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

(2008) Andleeb Zameer et al.   JOURNAL OF MOLECULAR BIOLOGY

Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation

(2008) Pierre Lafaye et al.   MOLECULAR IMMUNOLOGY

Development of a Smart Nano-vehicle to Target Cerebrovascular Amyloid Deposits and Brain Parenchymal Plaques Observed in Alzheimer’s Disease and Cerebral Amyloid Angiopathy

(2008) Edward K. Agyare et al.   PHARMACEUTICAL RESEARCH

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers

(2008) R. Robert et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42

(2007) R.S. Solórzano-Vargas et al.   MOLECULAR IMMUNOLOGY

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING