The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Deletion of Alzheimer's disease‐associated CD33 results in an inflammatory human microglia phenotype

(2021) Jannis Wißfeld et al.   GLIA

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

(2020) Colin D. Godwin et al.   LEUKEMIA

Putative cell type discovery from single-cell gene expression data

(2020) Zhichao Miao et al.   NATURE METHODS

Lipid and Lipoprotein Metabolism in Microglia

(2020) Bailey A. Loving et al.   Frontiers in Physiology

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Control of Innate Immunity by Sialic Acids in the Nervous Tissue

(2020) Huan Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A scalable SCENIC workflow for single-cell gene regulatory network analysis

(2020) Bram Van de Sande et al.   Nature Protocols

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

(2020) Emily Rodrigues et al.   Nature Communications

Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics

(2020) Anna Podleśny-Drabiniok et al.   TRENDS IN NEUROSCIENCES

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

(2019) Celia G. Fernandez et al.   Frontiers in Aging Neuroscience

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

CCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents

(2019) Ioannis Papageorgiou et al.   LEUKEMIA & LYMPHOMA

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen

(2019) Shiteng Duan et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease

(2019) Steven Estus et al.   ACTA NEUROPATHOLOGICA

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

(2019) Rebecca A. Drummond et al.   NATURE IMMUNOLOGY

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies

(2019) Florence Borot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Conceptual Evolution of Cell Signaling

(2019) Arathi Nair et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SRSF1 and PTBP1 are trans-acting factors that suppress the formation of a CD33 splicing isoform linked to Alzheimer's disease risk

(2019) Petra van Bergeijk et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

(2019) Franco-Bocanegra et al.   Cells

Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant

(2019) Sudeshna Saha et al.   ACTA NEUROPATHOLOGICA

The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System

(2019) Tatyana Veremeyko et al.   Frontiers in Cellular Neuroscience

KLF2 protects BV2 microglial cells against oxygen and glucose deprivation injury by modulating BDNF/TrkB pathway

(2019) Jingbin Zhou et al.   GENE

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

(2018) Miriam Y. Kim et al.   CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

(2018) Zhana Haimon et al.   NATURE IMMUNOLOGY

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2

(2018) Olivier Humbert et al.   LEUKEMIA

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool

(2017) Shoib S. Siddiqui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional control of microglia phenotypes in health and disease

(2017) Inge R. Holtman et al.   JOURNAL OF CLINICAL INVESTIGATION

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children’s Oncology Group Trial AAML0531

(2017) Jatinder K. Lamba et al.   JOURNAL OF CLINICAL ONCOLOGY

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model

(2017) Kyle J. Bednar et al.   JOURNAL OF IMMUNOLOGY

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

(2017) Katie J. Ryan et al.   Science Translational Medicine

Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

(2017) Anna-Elisa Roser et al.   Frontiers in Aging Neuroscience

Regulation of Microglial Phagocytosis by RhoA/ROCK-Inhibiting Drugs

(2016) Hannah Scheiblich et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The peroxisome as a cell signaling organelle

(2016) Durga Nand Tripathi et al.   CURRENT OPINION IN CELL BIOLOGY

Fosbgene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

(2014) Hiroko Nomaru et al.   GLIA

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

(2014) T. Raj et al.   HUMAN MOLECULAR GENETICS

Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis

(2014) Hong Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock

(2011) Ganapati H. Mahabeleshwar et al.   IMMUNITY

Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study

(2011) Minerva M Carrasquillo et al.   Molecular Neurodegeneration

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS