Hypoxia and brain aging: Neurodegeneration or neuroprotection?

A Rationale for Hypoxic and Chemical Conditioning in Huntington’s Disease

(2021) Johannes Burtscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

(2021) Johannes Burtscher et al.   MOVEMENT DISORDERS

Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

(2020) Hong Wang et al.   American Journal of Alzheimers Disease and Other Dementias

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain

(2020) Eugenia B. Manukhina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brainstem ventilatory dysfunction: A plausible mechanism for dyspnea in Parkinson's Disease?

(2020) Srimathy Vijayan et al.   MOVEMENT DISORDERS

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

The treatment of Goji berry (Lycium barbarum) improves the neuroplasticity of the prefrontal cortex and hippocampus in aged rats

(2020) Ana Karen Ruíz-Salinas et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration

(2020) M. Pokusa et al.   PHYSIOLOGICAL RESEARCH

Hypobaric hypoxia induced fear and extinction memory impairment and effect of Ginkgo biloba in its amelioration: Behavioral, neurochemical and molecular correlates

(2020) Punita Kumari et al.   BEHAVIOURAL BRAIN RESEARCH

Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults

(2020) Erika Iwamoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Parkinson’s disease: etiopathogenesis and treatment

(2020) Joseph Jankovic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer’s Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2

(2020) Yan Wang et al.   MOLECULAR NEUROBIOLOGY

Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

(2020) Chih-Hsin Lin et al.   Frontiers in Aging Neuroscience

Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

(2020) Sabah H. El-Ghaiesh et al.   Frontiers in Molecular Neuroscience

Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease

(2020) Veerta Sharma et al.   BIOMEDICINE & PHARMACOTHERAPY

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease

(2020) Yi Sun et al.   BIOORGANIC CHEMISTRY

Human adaptation to hypoxia in critical illness

(2020) Helen T. McKenna et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protective effects of Nrf2–ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1

(2020) Yuri Inose et al.   NEUROSCIENCE LETTERS

Lupeol, a Plant-Derived Triterpenoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration

(2020) Riaz Ahmad et al.   Biomedicines

Class switching of carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia

(2020) Kalpana Kumari Barhwal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma α -synuclein levels are increased in patients with obstructive sleep apnea syndrome

(2019) Hao-Lun Sun et al.   Annals of Clinical and Translational Neurology

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

(2019) Andrea Rodrigues Vasconcelos et al.   Frontiers in Pharmacology

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

(2019) Alberto J. Espay et al.   NEUROLOGY

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

Association of HIF1A and Parkinson’s disease in a Han Chinese population demonstrated by molecular inversion probe analysis

(2019) Lixia Qin et al.   NEUROLOGICAL SCIENCES

Up-regulation of HIF-1α is associated with neuroprotective effects of agmatine against rotenone-induced toxicity in differentiated SH-SY5Y cells

(2019) Nadia Ferlazzo et al.   AMINO ACIDS

Emergence of AnnexinVpos CD31neg CD42blow/neg extracellular vesicles in plasma of humans at extreme altitude

(2019) Olaf Utermöhlen et al.   PLoS One

Sex differences in respiratory and circulatory cost during hypoxic walking: potential impact on oxygen saturation

(2019) Masahiro Horiuchi et al.   Scientific Reports

Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults

(2019) Jennifer S. Rabin et al.   JAMA Neurology

Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases

(2019) Kwang Hun Lim   Frontiers in Molecular Neuroscience

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

(2019) Lígia Fão et al.   AGEING RESEARCH REVIEWS

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

(2019) Isha H. Jain et al.   Cell Metabolism

Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

(2019) Zoya O. Serebrovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer’s Disease Model

(2019) Eliezer Joseph et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes

(2019) Rupali Sharma et al.   Scientific Reports

Sex and age differentially affect GABAergic neurons in the mouse prefrontal cortex and hippocampus following chronic intermittent hypoxia

(2019) Batsheva R. Rubin et al.   EXPERIMENTAL NEUROLOGY

Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly

(2019) Xiaoli Liu et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Intermittent hypoxia and long-term neurological outcome: How are they related?

(2019) Christian F. Poets   Seminars in Fetal & Neonatal Medicine

Cognitive symptoms of Alzheimer’s disease: clinical management and prevention

(2019) Elizabeth Joe et al.   BMJ-British Medical Journal

Intermittent hypoxia improves cognition and reduces anxiety‐related behavior in APP/PS1 mice

(2019) Sheng‐Xi Meng et al.   Brain and Behavior

Hypoxic Conditioning in blood vessels and smooth muscle tissues: effects on function, mechanisms, and unknowns

(2018) Asmaa almohanna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study

(2018) Ram A. Sharma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

(2018) E. T. Zakharova et al.   BIOMETALS

The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease

(2018) Andreia G. Andrade et al.   JOURNAL OF ALZHEIMERS DISEASE

Intermittent hypoxia improves behavioral and adrenal gland dysfunction induced by post-traumatic stress disorder in rats

(2018) Eugenia B. Manukhina et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise Performance of Lowlanders with COPD at 2,590 m: Data from a Randomized Trial

(2018) Michael Furian et al.   RESPIRATION

Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function

(2018) Xuan Li et al.   Frontiers in Aging Neuroscience

Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review

(2018) Martin Burtscher et al.   Frontiers in Physiology

Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice

(2018) Satomi Shiota et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure

(2018) Antonio P. Mansur et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways

(2018) Tao Chen et al.   MOLECULAR NEUROBIOLOGY

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction

(2018) Limor Raz et al.   NEUROBIOLOGY OF DISEASE

Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

(2018) Mark B Vestergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

(2018) Natalia N. Nalivaeva et al.   Frontiers in Neuroscience

Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study

(2018) Anja Mähler et al.   Frontiers in Immunology

Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

(2018) Shuang-Feng Xu et al.   Redox Biology

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer’s Disease-Relevant Mouse Model

(2018) Teresa Macheda et al.   NEUROSCIENCE

Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries?

(2017) S Baillieul et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intermittent hypoxia initiated plasticity in humans: A multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities

(2017) Jason H. Mateika et al.   EXPERIMENTAL NEUROLOGY

Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation

(2017) Andrew E. Beaudin et al.   EXPERIMENTAL PHYSIOLOGY

Effect of ageing on hypoxic exercise cardiorespiratory, muscle and cerebral oxygenation responses in healthy humans

(2017) Lara Puthon et al.   EXPERIMENTAL PHYSIOLOGY

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

(2017) John Hardy   FEBS Journal

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration

(2017) Cátia F. Lourenço et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced cerebral perfusion during brief exposures to cyclic intermittent hypoxemia

(2017) Xiaoli Liu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human cerebral blood flow control during hypoxia: focus on chronic pulmonary obstructive disease and obstructive sleep apnea

(2017) Andrew E. Beaudin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

(2017) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice

(2017) Ignasi Jorba et al.   Journal of the Mechanical Behavior of Biomedical Materials

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Obstructive sleep apnea is associated with altered midbrain chemical concentrations

(2017) Paul M. Macey et al.   NEUROSCIENCE

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging

(2017) Sosuke Yagishita et al.   Molecular Brain

Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment

(2017) Yue Leng et al.   JAMA Neurology

Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

(2017) Alberto Serrano-Pozo et al.   PLoS One

Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning

(2017) Konstadina Griva et al.   PLoS One

Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms

(2016) Nancy A. Kerner et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

(2016) Eugenia B Manukhina et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

Poststroke Induction of  -Synuclein Mediates Ischemic Brain Damage

(2016) T. Kim et al.   JOURNAL OF NEUROSCIENCE

Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people

(2016) Lutz Schega et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Differences of brain electrical activity between moderate and severe obstructive sleep apneic patients: a LORETA study

(2016) Marton Toth et al.   JOURNAL OF SLEEP RESEARCH

Mechanisms of Memory Dysfunction during High Altitude Hypoxia Training in Military Aircrew

(2016) Daniel A. Nation et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging

(2016) Suryanarayan Biswal et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Re-exposure to the hypobaric hypoxic brain injury of high altitude: plasma S100B levels and the possible effect of acclimatisation on blood–brain barrier dysfunction

(2016) C. D. Winter et al.   NEUROLOGICAL SCIENCES

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Oxidative Stress-induced Telomere Length Shortening of Circulating Leukocyte in Patients with Obstructive Sleep Apnea

(2016) Kyung Soo Kim et al.   Aging and Disease

White Matter Integrity in High-Altitude Pilots Exposed to Hypobaria

(2016) Stephen A. McGuire et al.   Aerospace Medicine and Human Performance

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

(2016) Ara B. Hwang et al.   Aging-US

Accelerated Echo Planer J-resolved Spectroscopic Imaging of Putamen and Thalamus in Obstructive Sleep Apnea

(2016) Manoj K. Sarma et al.   Scientific Reports

CIH-induced neurocognitive impairments are associated with hippocampal Ca2+ overload, apoptosis, and dephosphorylation of ERK1/2 and CREB that are mediated by overactivation of NMDARs

(2015) Jing Wang et al.   BRAIN RESEARCH

A programme based on repeated hypoxia-hyperoxia exposure and light exercise enhances performance in athletes with overtraining syndrome: a pilot study

(2015) Davide Susta et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia

(2015) Jean-Paul Richalet et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity

(2015) Seyyed Hani Moussavi Nik et al.   HUMAN MOLECULAR GENETICS

Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

(2015) Berend Feddersen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

(2015) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinsonism after climbing high amplitude mountain: a case report

(2015) T. Hur   JOURNAL OF THE NEUROLOGICAL SCIENCES

Humans In Hypoxia: A Conspiracy Of Maladaptation?!

(2015) Jerome A. Dempsey et al.   PHYSIOLOGY

Ascent to moderate altitude impairs overnight memory improvements

(2015) Noemi Tesler et al.   PHYSIOLOGY & BEHAVIOR

Chronic Intermittent Hypoxia Induces Chronic Low-Grade Neuroinflammation in the Dorsal Hippocampus of Mice

(2015) Emilie Sapin et al.   SLEEP

Cerebral Hemodynamics at Altitude: Effects of Hyperventilation and Acclimatization on Cerebral Blood Flow and Oxygenation

(2015) Matthew R. Sanborn et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome

(2015) Xian-Le Bu et al.   Scientific Reports

Insights into the Evolution of Longevity from the Bowhead Whale Genome

(2015) Michael Keane et al.   Cell Reports

Association Between Alzheimer Dementia Mortality Rate and Altitude in California Counties

(2015) Stephen Thielke et al.   JAMA Psychiatry

Current insights into the molecular mechanisms of hypoxic pre- and postconditioning using hypobaric hypoxia

(2015) Elena Rybnikova et al.   Frontiers in Neuroscience

Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism

(2015) Caroline Kerridge et al.   Frontiers in Neuroscience

Odds Ratio Meta-Analysis and Increased Prevalence of White Matter Injury in Healthy Divers

(2015) Desmond M. Connolly et al.   Aerospace Medicine and Human Performance

Cognitive and psychomotor responses to high-altitude exposure in sea level and high-altitude residents of Ecuador

(2015) John E Davis et al.   Journal of Physiological Anthropology

Hypoxic Conditioning as a New Therapeutic Modality

(2015) Samuel Verges et al.   Frontiers in Pediatrics

Chronic Intermittent Hypoxia Induces Chronic Low-Grade Neuroinflammation in the Dorsal Hippocampus of Mice

(2015) Emilie Sapin et al.   SLEEP

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Accelerated Echo-Planar J-Resolved Spectroscopic Imaging in the Human Brain Using Compressed Sensing: A Pilot Validation in Obstructive Sleep Apnea

(2014) M. K. Sarma et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Therapeutic potential of intermittent hypoxia: a matter of dose

(2014) Angela Navarrete-Opazo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

White matter hyperintensities and hypobaric exposure

(2014) Stephen A. McGuire et al.   ANNALS OF NEUROLOGY

Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats

(2014) Xiao-Hong Cai et al.   EXPERIMENTAL NEUROLOGY

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP+ and/or hypoxia

(2014) Tao Chen et al.   EXPERIMENTAL NEUROLOGY

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance

(2014) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease

(2014) Hui Liu et al.   Translational Neurodegeneration

Denis Jourdanet (1815–1892) and the early recognition of the role of hypoxia at high altitude

(2013) John B. West et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cognition at Altitude: Impairment in Executive and Memory Processes Under Hypoxic Conditions

(2013) Deyar Asmaro et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Regulation of erythropoiesis by hypoxia-inducible factors

(2013) Volker H. Haase   BLOOD REVIEWS

Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!

(2013) Sónia C. Correia et al.   CURRENT PHARMACEUTICAL DESIGN

Cognitive performance in high-altitude climbers: a comparative study of saccadic eye movements and neuropsychological tests

(2013) Tobias M. Merz et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Effects of Intermittent Hypoxia on Cognitive Performance and Quality of Life in Elderly Adults: A Pilot Study

(2013) Lutz Schega et al.   GERONTOLOGY

Hypoxia Increases Aβ-Induced Tau Phosphorylation by Calpain and Promotes Behavioral Consequences in AD Transgenic Mice

(2013) Lianbo Gao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Hypoxic Preconditioning Attenuates Neuronal Cell Death by Preventing MEK/ERK Signaling Pathway Activation after Transient Global Cerebral Ischemia in Adult Rats

(2013) Lixuan Zhan et al.   MOLECULAR NEUROBIOLOGY

Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly

(2013) Lidia Glodzik et al.   NEUROBIOLOGY OF AGING

White matter hyperintensities on MRI in high-altitude U-2 pilots

(2013) S. McGuire et al.   NEUROLOGY

Regional cerebral blood flow alterations in obstructive sleep apnea

(2013) Santosh K. Yadav et al.   NEUROSCIENCE LETTERS

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

(2013) Mak Adam Daulatzai   NEUROTOXICITY RESEARCH

Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia

(2012) Navita Kaushal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Asymptomatic Brain Lesions in Pilots: A Comparative Study with Non-Flying Personnel Using Brain MRI

(2012) Daekeon Lim et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Effects of CPAP-Therapy on Brain Electrical Activity in Obstructive Sleep Apneic Patients: A Combined EEG Study Using LORETA and Omega Complexity

(2012) Marton Toth et al.   BRAIN TOPOGRAPHY

Improved Exercise Performance and Skeletal Muscle Strength After Simulated Altitude Exposure: A Novel Approach for Patients With Chronic Heart Failure

(2012) Omar Saeed et al.   JOURNAL OF CARDIAC FAILURE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer’s disease neuropathology in APPSwe/PS1A246E transgenic mice

(2012) Xin Zhang et al.   NEUROBIOLOGY OF AGING

Quintessential Risk Factors: Their Role in Promoting Cognitive Dysfunction and Alzheimer’s Disease

(2012) Mak Adam Daulatzai   NEUROCHEMICAL RESEARCH

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

High altitude exposure impairs sleep patterns, mood, and cognitive functions

(2012) Valdir Aquino Lemos et al.   PSYCHOPHYSIOLOGY

Carotid chemoreceptor “resetting” revisited

(2012) John L. Carroll et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study

(2012) Jeffrey Randall et al.   RESUSCITATION

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

Repetitive hypoxia extends endogenous neurovascular protection for stroke

(2011) Ann M. Stowe et al.   ANNALS OF NEUROLOGY

Hypoxia-induced angiogenesis is delayed in aging mouse brain

(2011) Girriso F. Benderro et al.   BRAIN RESEARCH

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude

(2011) Cassandra Richardson et al.   CLINICAL NEUROPHYSIOLOGY

Intermittent hypoxia conditioning prevents endothelial dysfunction and improves nitric oxide storage in spontaneously hypertensive rats

(2011) Eugenia B Manukhina et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

(2010) Scott F. Leiser et al.   BIOLOGICAL CHEMISTRY

Melatonin reduces hippocampal β-amyloid generation in rats exposed to chronic intermittent hypoxia

(2010) Kwong-Man Ng et al.   BRAIN RESEARCH

Cognitive function in COPD

(2010) J. W. Dodd et al.   EUROPEAN RESPIRATORY JOURNAL

S100B Profiles and Cognitive Function at High Altitude

(2010) Henrik Bjursten et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats

(2010) X.-H. Zhu et al.   JOURNAL OF NEUROSCIENCE

Hypoxic preconditioning failure in aging hippocampal neurons: Impaired gene expression and rescue with intracellular calcium chelation

(2010) Philip E. Bickler et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protein Misfolding Induces Hypoxic Preconditioning via a Subset of the Unfolded Protein Response Machinery

(2010) X. R. Mao et al.   MOLECULAR AND CELLULAR BIOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity

(2010) Hui Xie et al.   NEUROBIOLOGY OF DISEASE

Nitric Oxide Signaling in Brain Function, Dysfunction, and Dementia

(2010) Joern R. Steinert et al.   NEUROSCIENTIST

Adaptation to intermittent hypoxia restricts nitric oxide overproduction and prevents beta-amyloid toxicity in rat brain

(2010) Anna V. Goryacheva et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis

(2010) Luc J. Teppema et al.   PHYSIOLOGICAL REVIEWS

Hypoxia and Neurodegeneration

(2009) Chris Peers et al.   Annals of the New York Academy of Sciences

Characteristic Changes in Brain Electrical Activity Due to Chronic Hypoxia in Patients with Obstructive Sleep Apnea Syndrome (OSAS): A Combined EEG Study Using LORETA and Omega Complexity

(2009) Marton Toth et al.   BRAIN TOPOGRAPHY

Role of Nitric Oxide in Prevention of Cognitive Disorders in Neurodegenerative Brain Injuries in Rats

(2009) E. B. Manukhina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease

(2009) Thomas Haider et al.   JOURNAL OF HYPERTENSION

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

(2009) Sónia C. Correia et al.   JOURNAL OF NEUROCHEMISTRY

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

The cerebral effects of ascent to high altitudes

(2009) Mark H Wilson et al.   LANCET NEUROLOGY

Generating specificity and diversity in the transcriptional response to hypoxia

(2009) Urban Lendahl et al.   NATURE REVIEWS GENETICS

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Cognitive Assessment of a Trekking Expedition to 5100 m: A Comparison of Computerized and Written Testing Methods

(2009) Gregory A. Harris et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

(2008) P J Syapin   BRITISH JOURNAL OF PHARMACOLOGY

Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?

(2008) Tatiana V. Serebrovskaya et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Brain-Derived Neurotrophic Factor Is Associated With Cognitive Function in Healthy Older Adults

(2008) John Gunstad et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE