Role of ABCA7 in Human Health and in Alzheimer’s Disease

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

(2021) Leonor Jacobo-Albavera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

(2021) Johannes Wurm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound

(2021) Sara Wellens et al.   TOXICOLOGY IN VITRO

rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer’s disease patients compared with controls

(2020) Guiyou Liu et al.   ACTA NEUROPATHOLOGICA

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

(2020) Eva Gil-Martins et al.   PHARMACOLOGY & THERAPEUTICS

The impact of ATP-binding cassette transporters on metabolic diseases

(2020) Zixiang Ye et al.   Nutrition & Metabolism

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

(2020) Hannah Chew et al.   Frontiers in Physiology

miR-197-3p reduces epithelial–mesenchymal transition by targeting ABCA7 in ovarian cancer cells

(2020) Weiquan Xie et al.   3 Biotech

Structural and functional diversity calls for a new classification of ABC transporters

(2020) Christoph Thomas et al.   FEBS LETTERS

Acute regulation of apical ABC transporters in the gut. Potential influence on drug bioavailability

(2020) Camila Juliana Domínguez et al.   PHARMACOLOGICAL RESEARCH

ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease

(2020) Nicholas N. Lyssenko et al.   Alzheimers & Dementia

The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomics

(2019) Arne De Roeck et al.   ACTA NEUROPATHOLOGICA

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

(2019) Tomonori Aikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer

(2019) Michela Pasello et al.   SEMINARS IN CANCER BIOLOGY

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition

(2019) Michael Vacher et al.   Scientific Reports

A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer’s Disease

(2018) Christian Wachinger et al.   BIOLOGICAL PSYCHIATRY

ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

(2018) Yordenca Lamartinière et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis

(2018) Liana G. Apostolova et al.   JAMA Neurology

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation

(2018) Julien Saint-Pol et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction Between Two Cholesterol Metabolism Genes Influences Memory: Findings from the Wisconsin Registry for Alzheimer's Prevention

(2018) Corinne D. Engelman et al.   JOURNAL OF ALZHEIMERS DISEASE

ATP‑binding cassette transporter A7 accelerates epithelial‑to‑mesenchymal transition in ovarian cancer cells by upregulating the transforming growth factor‑β signaling pathway

(2018) Xia Liu et al.   Oncology Letters

ABCA7 risk variant in healthy older African Americans is associated with a functionally isolated entorhinal cortex mediating deficient generalization of prior discrimination training

(2018) Neha Sinha et al.   HIPPOCAMPUS

ABC Transporters Are Key Players in Alzheimer’s Disease

(2017) Cátia D. Pereira et al.   JOURNAL OF ALZHEIMERS DISEASE

Late Onset Alzheimer’s Disease Risk Variants in Cognitive Decline: The PATH Through Life Study

(2017) Shea J. Andrews et al.   JOURNAL OF ALZHEIMERS DISEASE

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls

(2017) Céline Bellenguez et al.   NEUROBIOLOGY OF AGING

Gene-based aggregate SNP associations between candidate AD genes and cognitive decline

(2016) Jasmine Nettiksimmons et al.   AGE

Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

(2016) Jonathan M. Schott et al.   Alzheimers & Dementia

Abca7 deletion does not affect adult neurogenesis in the mouse

(2016) H. Li et al.   BIOSCIENCE REPORTS

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

(2016) YuHong Fu et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

(2016) Nobutaka Sakae et al.   JOURNAL OF NEUROSCIENCE

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

(2016) Leslie M. Ramirez et al.   NEUROBIOLOGY OF AGING

Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology

(2016) Gennady V. Roshchupkin et al.   NEUROBIOLOGY OF AGING

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing

(2015) Kanayo Satoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease

(2015) Minerva M. Carrasquillo et al.   NEUROBIOLOGY OF AGING

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD

(2014) M. M. Carrasquillo et al.   NEUROLOGY

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

(2013) Julien Saint-Pol et al.   BRAIN RESEARCH

Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice

(2013) Jacqueline Hofrichter et al.   Current Alzheimer Research

Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier

(2013) Fabien Gosselet et al.   Current Alzheimer Research

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Markers of cholesterol transport are associated with amyloid deposition in the brain

(2013) Timothy M. Hughes et al.   NEUROBIOLOGY OF AGING

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

(2013) Joshua M. Shulman et al.   JAMA Neurology

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

(2012) M. Allen et al.   NEUROLOGY

Correction: Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1

(2012) Illiana Meurs et al.   PLoS One

Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases

(2012) Warren Logge et al.   PLoS One

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

(2010) Nobukiyo Tanaka et al.   JOURNAL OF LIPID RESEARCH

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease and blood–brain barrier function—Why have anti-β-amyloid therapies failed to prevent dementia progression?

(2009) Jens Pahnke et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model

(2008) Fabien Gosselet et al.   BRAIN RESEARCH

Effect of ABCA1 mutations on risk for myocardial infarction

(2008) Iulia Iatan et al.   Current Atherosclerosis Reports

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP-binding cassette transporter A7 regulates processing of amyloid precursor proteinin vitro

(2008) Sharon L. Chan et al.   JOURNAL OF NEUROCHEMISTRY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY