Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
Authors
Keywords
-
Journal
Advanced Science
Volume 8, Issue 16, Pages 2101090
Publisher
Wiley
Online
2021-06-04
DOI
10.1002/advs.202101090
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The entry of nanoparticles into solid tumours
- (2020) Shrey Sindhwani et al. NATURE MATERIALS
- Neutrophils as emerging therapeutic targets
- (2020) Tamás Németh et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
- (2020) Katarzyna A. Dudek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
- (2020) Oscar A. Marcos-Contreras et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry
- (2020) Hamid Salimi et al. mBio
- Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
- (2020) Xiangqi Meng et al. Nature Communications
- MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes
- (2020) Heng Hu et al. Scientific Reports
- Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance
- (2020) Filip Roudnicky et al. Scientific Reports
- FTY720 Protects Against Ischemia–Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model
- (2020) Zifeng Wang et al. Translational Stroke Research
- MicroRNAs: Possible Regulatory Molecular Switch Controlling the BBB Microenvironment
- (2020) Chiranjib Chakraborty et al. Molecular Therapy-Nucleic Acids
- Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment
- (2020) Yan Zou et al. ADVANCED MATERIALS
- VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content
- (2020) Christine Moessinger et al. EMBO REPORTS
- Deliver anti-PD-L1 into brain by p-hydroxybenzoic acid to enhance immunotherapeutic effect for glioblastoma
- (2020) Haiyan Guo et al. JOURNAL OF CONTROLLED RELEASE
- The blood–brain barrier in health and disease: Important unanswered questions
- (2020) Caterina P. Profaci et al. JOURNAL OF EXPERIMENTAL MEDICINE
- APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
- (2020) Axel Montagne et al. NATURE
- Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound
- (2020) Ali R. Rezai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke
- (2020) Feifei Ma et al. Science Signaling
- Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
- (2020) Ross O Smith et al. eLife
- Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier
- (2020) Zhifu Wang et al. Science Advances
- Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation
- (2020) William A. Banks et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice
- (2020) Jia Li et al. PLOS BIOLOGY
- Vascular dysfunction—The disregarded partner of Alzheimer's disease
- (2019) Melanie D. Sweeney et al. Alzheimers & Dementia
- Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10
- (2019) Olga L. Rojas et al. CELL
- Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
- (2019) Daniel A. Nation et al. NATURE MEDICINE
- Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges
- (2019) Victor M. Pulgar Frontiers in Neuroscience
- Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model
- (2019) Mario Merlini et al. NEURON
- Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
- (2019) Zheng Gang Zhang et al. Nature Reviews Neurology
- Adeno-associated virus vector as a platform for gene therapy delivery
- (2019) Dan Wang et al. NATURE REVIEWS DRUG DISCOVERY
- MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
- (2019) Daniella Dwir et al. MOLECULAR PSYCHIATRY
- Minocycline and the risk of acute psychiatric events in adolescence: A self-controlled case series
- (2019) Ruth Brauer et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo
- (2019) Kasper Bendix Johnsen et al. JOURNAL OF CONTROLLED RELEASE
- Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
- (2019) Ana I. Casas et al. JOURNAL OF CLINICAL INVESTIGATION
- Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals
- (2019) Ida Juul Rasmussen et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression
- (2019) Yu Yamazaki et al. BRAIN
- Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain
- (2019) Oscar A. Marcos-Contreras et al. JOURNAL OF CONTROLLED RELEASE
- SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
- (2019) Linzhang Huang et al. NATURE
- Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
- (2019) Hanadie Yousef et al. NATURE MEDICINE
- The role of short-chain fatty acids in microbiota–gut–brain communication
- (2019) Boushra Dalile et al. Nature Reviews Gastroenterology & Hepatology
- Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix
- (2019) Benjamin J. Umlauf et al. Science Advances
- ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy
- (2019) Meng Zheng et al. ADVANCED MATERIALS
- Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
- (2019) Gil Sharon et al. CELL
- Tumour-associated neutrophils in patients with cancer
- (2019) Merav E. Shaul et al. Nature Reviews Clinical Oncology
- Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
- (2019) Annamaria Vezzani et al. Nature Reviews Neurology
- Macrophages at CNS interfaces: ontogeny and function in health and disease
- (2019) Katrin Kierdorf et al. NATURE REVIEWS NEUROSCIENCE
- Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke
- (2019) Ruslan Rust et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke
- (2019) An-Qi Chen et al. Cell Death & Disease
- Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody
- (2019) Phillip W. Janowicz et al. Scientific Reports
- Synergistic Role of Oxidative Stress and Blood-Brain Barrier Permeability as Injury Mechanisms in the Acute Pathophysiology of Blast-induced Neurotrauma
- (2019) Matthew Kuriakose et al. Scientific Reports
- Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration
- (2019) Mattaka Khongkow et al. Scientific Reports
- Exosomal DNA aptamer targeting α-synuclein aggregates reduced neuropathological deficits in a mouse Parkinson’s Disease model
- (2019) Xiaoxi Ren et al. Molecular Therapy-Nucleic Acids
- Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
- (2019) Golnaz Morad et al. ACS Nano
- Transcytosis at the blood–brain barrier
- (2019) Swathi Ayloo et al. CURRENT OPINION IN NEUROBIOLOGY
- Chronic inflammation in multiple sclerosis — seeing what was always there
- (2019) Paul M. Matthews Nature Reviews Neurology
- Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis
- (2019) Stephanie Bonney et al. mBio
- Suppression of transcytosis regulates zebrafish blood-brain barrier function
- (2019) Natasha M O'Brown et al. eLife
- Accessing neuroinflammation sites: Monocyte/neutrophil-mediated drug delivery for cerebral ischemia
- (2019) Jia Hou et al. Science Advances
- Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice
- (2019) Jing Wen et al. Nature Biomedical Engineering
- Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module
- (2019) Roeben Nocon Munji et al. NATURE NEUROSCIENCE
- Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
- (2019) Lin-Ping Wu et al. Nature Communications
- First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
- (2019) Agessandro Abrahao et al. Nature Communications
- Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
- (2019) Anna Galstyan et al. Nature Communications
- Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis
- (2019) Mette Mathiesen Janiurek et al. eLife
- Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease
- (2019) Robert Howard et al. JAMA Neurology
- Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations
- (2019) Daniel Y. Zhang et al. CLINICAL CANCER RESEARCH
- Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex
- (2019) Chengyan Chu et al. JOURNAL OF CONTROLLED RELEASE
- Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction
- (2019) Vladimir V. Senatorov et al. Science Translational Medicine
- Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
- (2019) Koichiro Haruwaka et al. Nature Communications
- Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
- (2019) Zhaogang Yang et al. Nature Biomedical Engineering
- Permeability of the blood-brain barrier predicts no evidence of disease activity at 2 years after natalizumab or fingolimod treatment in relapsing-remitting multiple sclerosis
- (2018) Stig P. Cramer et al. ANNALS OF NEUROLOGY
- MicroRNA-Mediated Therapy Modulating Blood–Brain Barrier Disruption Improves Vascular Cognitive ImpairmentHighlights
- (2018) Kensuke Toyama et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
- (2018) Yuyan Cheng et al. BRAIN BEHAVIOR AND IMMUNITY
- Bridging barriers: a comparative look at the blood–brain barrier across organisms
- (2018) Natasha M. O'Brown et al. GENES & DEVELOPMENT
- A novel IL-1RA-PEP fusion protein alleviates blood-brain barrier disruption after ischemia-reperfusion in male rats
- (2018) Dong-Dong Zhang et al. Journal of Neuroinflammation
- Mechanisms of clathrin-mediated endocytosis
- (2018) Marko Kaksonen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. Nature Reviews Neurology
- Early Blood–Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules
- (2018) Angelika Hoffmann et al. STROKE
- Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy
- (2018) Meng Zheng et al. TRENDS IN BIOTECHNOLOGY
- Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
- (2018) Fred C. Lam et al. Nature Communications
- Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
- (2018) Ryosuke Kojima et al. Nature Communications
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
- (2018) Nir Lipsman et al. Nature Communications
- Progress and challenges towards targeted delivery of cancer therapeutics
- (2018) Daniel Rosenblum et al. Nature Communications
- Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases
- (2018) Sara Gerhardt et al. Nutrients
- Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
- (2018) Shweta Tiwary et al. Scientific Reports
- Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
- (2018) Kasper Bendix Johnsen et al. Theranostics
- A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology
- (2018) Vibhor Krishna et al. JAMA Neurology
- A molecular atlas of cell types and zonation in the brain vasculature
- (2018) Michael Vanlandewijck et al. NATURE
- The role of brain vasculature in neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. NATURE NEUROSCIENCE
- Gene therapy for neurological disorders: progress and prospects
- (2018) Benjamin E. Deverman et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils
- (2018) Andreas Noack et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
- (2018) Juan Guan et al. Nature Communications
- Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
- (2018) Mark F Sabbagh et al. eLife
- Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme
- (2018) David J. Lundy et al. ACS Nano
- Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine
- (2018) Yan Zou et al. ADVANCED MATERIALS
- Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models
- (2018) Ka Ka Ting et al. DIABETOLOGIA
- Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation
- (2018) Ellinor Kenne et al. FASEB JOURNAL
- Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
- (2018) Viktoria Zoufal et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
- (2018) Minako Ito et al. NATURE
- Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release
- (2018) Kerstin Göbel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma
- (2018) Meiying Wu et al. Nature Communications
- Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
- (2018) Kathleen Hübner et al. Nature Communications
- Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
- (2017) Ling Zhang et al. JOURNAL OF ALZHEIMERS DISEASE
- Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
- (2017) Rudy Chang et al. MOLECULAR PHARMACEUTICS
- Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model
- (2017) Brian P. Mead et al. NANO LETTERS
- Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
- (2017) Alan T. Tang et al. NATURE
- Rationalizing combination therapies
- (2017) NATURE MEDICINE
- Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence
- (2017) Jingwei Xue et al. Nature Nanotechnology
- Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
- (2017) Ken Y Chan et al. NATURE NEUROSCIENCE
- Social stress induces neurovascular pathology promoting depression
- (2017) Caroline Menard et al. NATURE NEUROSCIENCE
- Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells
- (2017) Hui K. Gan et al. Nature Reviews Clinical Oncology
- A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers
- (2017) Mathieu Coureuil et al. NATURE REVIEWS MICROBIOLOGY
- Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data
- (2017) Jann N Sarkaria et al. NEURO-ONCOLOGY
- Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
- (2017) Benjamin J. Andreone et al. NEURON
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
- (2017) Costantino Iadecola NEURON
- Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury
- (2017) Yejie Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1
- (2017) Keisuke Yanagida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood–brain barrier impairment
- (2017) Mario J. Aragon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
- (2017) Ana I. Casas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
- (2017) Fumitaka Shimizu et al. Science Translational Medicine
- Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
- (2017) Choi-Fong Cho et al. Nature Communications
- Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
- (2017) Y. Anraku et al. Nature Communications
- Photodynamic opening of blood-brain barrier
- (2017) Oxana Semyachkina-Glushkovskaya et al. Biomedical Optics Express
- Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation
- (2017) Sarah E. Lutz et al. Cell Reports
- SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1
- (2017) Karen Y. Fung et al. Frontiers in Physiology
- Maintenance of Blood-Brain Barrier Integrity in Hypertension: A Novel Benefit of Exercise Training for Autonomic Control
- (2017) Leila Buttler et al. Frontiers in Physiology
- Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia
- (2017) Jialei Yang et al. Molecular Therapy-Nucleic Acids
- Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?
- (2017) Junichi Matsumoto et al. Acta Neuropathologica Communications
- Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition
- (2017) Laura B. Jaeger et al. JOURNAL OF ALZHEIMERS DISEASE
- CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease
- (2016) Min Shi et al. Alzheimers & Dementia
- Febrile infection-related epilepsy syndrome treated with anakinra
- (2016) Daniel L. Kenney-Jung et al. ANNALS OF NEUROLOGY
- Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery
- (2016) Benjamí Oller-Salvia et al. CHEMICAL SOCIETY REVIEWS
- A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier
- (2016) Do-Geun Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
- (2016) Benjamin E Deverman et al. NATURE BIOTECHNOLOGY
- Pericytes of the neurovascular unit: key functions and signaling pathways
- (2016) Melanie D Sweeney et al. NATURE NEUROSCIENCE
- From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
- (2016) William A. Banks NATURE REVIEWS DRUG DISCOVERY
- Vascular endothelial growth factor: a neurovascular target in neurological diseases
- (2016) Christian Lange et al. Nature Reviews Neurology
- Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
- (2016) Y. Joy Yu Zuchero et al. NEURON
- Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
- (2016) Jonas Kloepper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation
- (2016) Zsofia I. Kovacs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
- (2016) Harm J. van de Haar et al. RADIOLOGY
- Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling
- (2016) Emily G. Severance et al. SCHIZOPHRENIA RESEARCH
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
- (2016) Robert Shenkar et al. STROKE
- Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
- (2016) Yejie Shi et al. Nature Communications
- Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
- (2016) Anna Herland et al. PLoS One
- An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
- (2016) Nicole M. Smith et al. Scientific Reports
- Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection
- (2015) Dafeng Chu et al. ACS Nano
- Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
- (2015) Stéphanie Debette et al. BIOLOGICAL PSYCHIATRY
- Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
- (2015) Hisham Qosa et al. BRAIN RESEARCH
- Anti–IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus
- (2015) Jiyong Zhang et al. FASEB JOURNAL
- Brain barriers: Crosstalk between complex tight junctions and adherens junctions
- (2015) Silvia Tietz et al. JOURNAL OF CELL BIOLOGY
- Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier
- (2015) Steffen E. Storck et al. JOURNAL OF CLINICAL INVESTIGATION
- Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles
- (2015) Miyuki Baba et al. JOURNAL OF CONTROLLED RELEASE
- Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery
- (2015) Seyed Nasrollah Tabatabaei et al. JOURNAL OF CONTROLLED RELEASE
- Monocyte mediated brain targeting delivery of macromolecular drug for the therapy of depression
- (2015) Jing Qin et al. Nanomedicine-Nanotechnology Biology and Medicine
- The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
- (2015) Jonathan J Miner et al. NATURE MEDICINE
- GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
- (2015) Ethan A Winkler et al. NATURE NEUROSCIENCE
- Neuroimmune mechanisms of depression
- (2015) Georgia E Hodes et al. NATURE NEUROSCIENCE
- A holistic approach to targeting disease with polymeric nanoparticles
- (2015) Christopher J. Cheng et al. NATURE REVIEWS DRUG DISCOVERY
- Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
- (2015) Axel Montagne et al. NEURON
- Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier
- (2015) Helen M. Lazear et al. Science Translational Medicine
- Sphingosine 1-phosphate signaling at the blood–brain barrier
- (2015) Briana Prager et al. TRENDS IN MOLECULAR MEDICINE
- Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration
- (2015) Jian Song et al. Cell Reports
- Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System
- (2015) Brian P. Daniels et al. PLoS Pathogens
- Efflux transporters in blood-brain interfaces of the developing brain
- (2015) Nathalie Strazielle et al. Frontiers in Neuroscience
- Autoregulated paracellular clearance of amyloid- across the blood-brain barrier
- (2015) J. Keaney et al. Science Advances
- The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis
- (2014) L.K. Too et al. BRAIN BEHAVIOR AND IMMUNITY
- Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
- (2014) Michel Demeule et al. JOURNAL OF CLINICAL INVESTIGATION
- Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
- (2014) Nga Bien-Ly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activity of P-Glycoprotein, a -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease
- (2014) A. K. Deo et al. JOURNAL OF NUCLEAR MEDICINE
- Mfsd2a is critical for the formation and function of the blood–brain barrier
- (2014) Ayal Ben-Zvi et al. NATURE
- Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
- (2014) Long N. Nguyen et al. NATURE
- Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle
- (2014) Jens Niewoehner et al. NEURON
- Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke
- (2014) Daniel Knowland et al. NEURON
- Acute hypertension induces brain injury and blood–brain barrier disruption through reduction of claudins mRNA expression in rat
- (2014) Mohammad Taghi Mohammadi et al. PATHOLOGY RESEARCH AND PRACTICE
- Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
- (2014) Y. J. Yu et al. Science Translational Medicine
- The gut microbiota influences blood-brain barrier permeability in mice
- (2014) V. Braniste et al. Science Translational Medicine
- Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
- (2014) Ricardo Cabezas et al. Frontiers in Cellular Neuroscience
- Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals
- (2014) B. P. Daniels et al. mBio
- On-the-fly decoding luminescence lifetimes in the microsecond region for lanthanide-encoded suspension arrays
- (2014) Yiqing Lu et al. Nature Communications
- Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
- (2014) Michael R. Jablonski et al. Annals of Clinical and Translational Neurology
- PKCβ Promotes Vascular Inflammation and Acceleration of Atherosclerosis in Diabetic ApoE Null Mice
- (2013) Linghua Kong et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27
- (2013) J. A. Young et al. BLOOD
- Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins
- (2013) Natalia L Klyachko et al. Nanomedicine
- EndMT contributes to the onset and progression of cerebral cavernous malformations
- (2013) Luigi Maddaluno et al. NATURE
- Partial recovery of the damaged rat blood–brain barrier is mediated by adherens junction complexes, extracellular matrix remodeling and macrophage infiltration following focal astrocyte loss
- (2013) C.L. Willis et al. NEUROSCIENCE
- Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration
- (2013) Ana-Maria Enciu et al. Oxidative Medicine and Cellular Longevity
- Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications
- (2013) E. Cristante et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein kinase Cβ as a therapeutic target stabilizing blood–brain barrier disruption in experimental autoimmune encephalomyelitis
- (2013) Tobias V. Lanz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nogo-A is a negative regulator of CNS angiogenesis
- (2013) T. Walchli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
- (2013) J. A. Couch et al. Science Translational Medicine
- Endothelial Cell-to-Cell Junctions: Adhesion and Signaling in Physiology and Pathology
- (2013) M. G. Lampugnani Cold Spring Harbor Perspectives in Medicine
- Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease
- (2012) Alaa H. Abuznait et al. ACS Chemical Neuroscience
- T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion
- (2012) J. P. Hindley et al. CANCER RESEARCH
- Adsorptive-Mediated Brain Delivery Systems
- (2012) Wei Lu CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis
- (2012) Soo Young Kim et al. EPILEPSIA
- Junctional Protein Regulation by Sphingosine Kinase 2 Contributes to Blood–Brain Barrier Protection in Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance
- (2012) Bradley K Wacker et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage
- (2012) J. Liu et al. JOURNAL OF NEUROSCIENCE
- Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels
- (2012) Debayon Paul et al. MICROVASCULAR RESEARCH
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
- (2012) Ethan S Lippmann et al. NATURE BIOTECHNOLOGY
- Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
- (2012) Alessandro Parodi et al. Nature Nanotechnology
- Nanotechnology—novel therapeutics for CNS disorders
- (2012) Maya Srikanth et al. Nature Reviews Neurology
- Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier
- (2012) Michelle A. Erickson et al. NEUROIMMUNOMODULATION
- Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
- (2012) R. E. Cannon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
- (2012) Z. Cheng et al. SCIENCE
- Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies
- (2012) Charles Pin-Kuang Lai et al. Frontiers in Physiology
- Co-Regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium by Dynamin and Rac
- (2011) Susan M. Armstrong et al. AMERICAN JOURNAL OF PATHOLOGY
- Identification of peptide sequences that target to the brain using in vivo phage display
- (2011) Jingwei Li et al. AMINO ACIDS
- Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions
- (2011) Linnea R. Freeman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Blood–brain barrier P-glycoprotein function in Alzheimer's disease
- (2011) Daniëlle M. E. van Assema et al. BRAIN
- Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
- (2011) Maria M. Mihaylova et al. CELL
- Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
- (2011) Markus Krohn et al. JOURNAL OF CLINICAL INVESTIGATION
- Sera from neuromyelitis optica patients disrupt the blood–brain barrier
- (2011) Fumitaka Shimizu et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
- (2011) Berislav V. Zlokovic NATURE REVIEWS NEUROSCIENCE
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease
- (2011) Yi Yang et al. STROKE
- Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium
- (2010) Weiyong Shen et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Angiotensin II sustains brain inflammation in mice via TGF-β
- (2010) Tobias V. Lanz et al. JOURNAL OF CLINICAL INVESTIGATION
- Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid- in a Mouse Model of Alzheimer's Disease
- (2010) A. M. S. Hartz et al. MOLECULAR PHARMACOLOGY
- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
- (2010) Volker Brinkmann et al. NATURE REVIEWS DRUG DISCOVERY
- Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury
- (2010) Dan Shlosberg et al. Nature Reviews Neurology
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- Characteristics of compounds that cross the blood-brain barrier
- (2009) William A Banks BMC Neurology
- Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
- (2009) Bayani Uttara et al. Current Neuropharmacology
- Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice
- (2009) D M McCarty et al. GENE THERAPY
- Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience
- (2009) Lilyana Angelov et al. JOURNAL OF CLINICAL ONCOLOGY
- Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
- (2009) Kendle M. Maslowski et al. NATURE
- VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
- (2009) Azeb Tadesse Argaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
- (2008) Michel Demeule et al. JOURNAL OF NEUROCHEMISTRY
- Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
- (2008) Kevin D Foust et al. NATURE BIOTECHNOLOGY
- Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
- (2008) Andrea Taddei et al. NATURE CELL BIOLOGY
- SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function
- (2007) Ruud D. Fontijn et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis
- (2007) Yann Wallez et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started