Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

(2018) Andrea Huwiler et al.   PHARMACOLOGY & THERAPEUTICS

Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury

(2018) Nathalie Burg et al.   Arthritis & Rheumatology

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

(2018) Jia Pei Chan et al.   PLOS BIOLOGY

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model

(2016) Ana Rubio-Araiz et al.   ADDICTION BIOLOGY

Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury

(2016) Wenting Zhang et al.   NEUROBIOLOGY OF DISEASE

CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes

(2016) Zhifei He et al.   PLoS One

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Blood-Brain Barrier: A Dual Life of MFSD2A?

(2014) Zhen Zhao et al.   NEURON

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor

(2010) D. Zhu et al.   BLOOD

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY