Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

(2017) Felice Gragnano et al.   MEDIATORS OF INFLAMMATION

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells

(2017) Xiao-Ling Hu et al.   NEURON

Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo

(2016) Junliang Pan et al.   BLOOD

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

(2016) Andrea Wolf et al.   PLoS One

Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

(2015) L. Vivash et al.   JOURNAL OF NUCLEAR MEDICINE

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

(2015) Hanadie Yousef et al.   Oncotarget

Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans

(2015) Jinah Han et al.   Cell Reports

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Vascular cell adhesion molecule-1 (VCAM-1)-An increasing insight into its role in tumorigenicity and metastasis

(2014) Martin Schlesinger et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing

(2014) Mike Lee et al.   NATURE IMMUNOLOGY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Influence of Aggregation and Route of Injection on the Biodistribution of Mouse Serum Albumin

(2014) Grzegorz Kijanka et al.   PLoS One

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury

(2014) Jian Luo et al.   Frontiers in Neurology

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression

(2012) Erzsebet Kokovay et al.   Cell Stem Cell

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging

(2012) J. Vukovic et al.   JOURNAL OF NEUROSCIENCE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis

(2011) C.-F. Calvo et al.   GENES & DEVELOPMENT

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome

(2011) Markus Britschgi et al.   MOLECULAR & CELLULAR PROTEOMICS

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Regulation of Endothelial Cell Adhesion Molecule Expression by Mast Cells, Macrophages, and Neutrophils

(2011) Jie Zhang et al.   PLoS One

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

(2010) Joan M. Cook-Mills et al.   ANTIOXIDANTS & REDOX SIGNALING

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions

(2010) B. Rossi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma

(2010) YOSHINAGA OKUGAWA et al.   Experimental and Therapeutic Medicine

High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)–Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations

(2010) Angelika Hoffmann et al.   Translational Stroke Research

Blood-based biomarkers of microvascular pathology in Alzheimer’s disease

(2009) Michael Ewers et al.   EXPERIMENTAL GERONTOLOGY

Neurogenesis and Alzheimer's disease: At the crossroads

(2009) Orly Lazarov et al.   EXPERIMENTAL NEUROLOGY

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE