Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I

(2018) William M. Pardridge et al.   BIODRUGS

Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms

(2018) Hélène FE Gleitz et al.   EMBO Molecular Medicine

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

(2018) M.J. Ramalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

(2018) George Thom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II

(2018) Hiroyuki Sonoda et al.   MOLECULAR THERAPY

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

(2018) Roberto Giugliani et al.   Orphanet Journal of Rare Diseases

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

(2018) Kasper Bendix Johnsen et al.   Theranostics

Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode

(2018) Felix Weber et al.   Cell Reports

Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier

(2017) Yves Molino et al.   FASEB JOURNAL

Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier

(2017) Arsalan S Haqqani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse–Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse

(2017) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

(2017) Carl I. Webster et al.   PAIN

High-resolution Confocal Imaging of the Blood-brain Barrier: Imaging, 3D Reconstruction, and Quantification of Transcytosis

(2017) Roberto Villaseñor et al.   Jove-Journal of Visualized Experiments

Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

(2017) Mehdi Arbabi-Ghahroudi   Frontiers in Immunology

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

ANG1005 for breast cancer brain metastases: correlation between 18F-FLT–PET after first cycle and MRI in response assessment

(2016) C. C. O’Sullivan et al.   BREAST CANCER RESEARCH AND TREATMENT

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

(2016) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Transferrin liposomes of docetaxel for brain-targeted cancer applications: formulation and brain theranostics

(2016) Sonali et al.   DRUG DELIVERY

ABC transporters at the blood–brain barrier

(2016) Anne Mahringer et al.   Expert Opinion on Drug Metabolism & Toxicology

Brain penetration, target engagement, and disposition of the blood–brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1

(2016) Carl I. Webster et al.   FASEB JOURNAL

Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles

(2016) Lin Wei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel Antitransferrin Receptor Antibodies Improve the Blood–Brain Barrier Crossing Efficacy of Immunoliposomes

(2016) Maria Gregori et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dual Functional Peptide-Driven Nanoparticles for Highly Efficient Glioma-Targeting and Drug Codelivery

(2016) Yuyang Kuang et al.   MOLECULAR PHARMACEUTICS

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

(2015) Jason M. Lajoie et al.   Annual Review of Pharmacology and Toxicology

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

(2015) Sarah Paris-Robidas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood–Brain Barrier

(2015) Itsaso Cabezón et al.   MOLECULAR PHARMACEUTICS

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Insulin receptor antibody-iduronate 2-sulfatase fusion protein: Pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

(2014) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Role of Pericytes in Neurovascular Unit Remodeling in Brain Disorders

(2014) Ayman ElAli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

(2014) Michel Demeule et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells

(2014) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding

(2014) Hadassah Sade et al.   PLoS One

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA

(2013) Nicolina Cristina Sorrentino et al.   EMBO Molecular Medicine

Cell penetrating peptide tethered bi-ligand liposomes for delivery to brain in vivo: Biodistribution and transfection

(2013) Gitanjali Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

(2012) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

Adsorptive-Mediated Brain Delivery Systems

(2012) Wei Lu   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method

(2012) Arsalan S. Haqqani et al.   MOLECULAR PHARMACEUTICS

Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model

(2012) Sylvia Wagner et al.   PLoS One

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys

(2012) Sachiko Ohshima-Hosoyama et al.   PLoS One

Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein

(2011) Jeff Zhiqiang Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

The endosomal network

(2011) D.A. Brooks   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein

(2010) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood–brain barrier

(2010) Ailing Fu et al.   BRAIN RESEARCH

Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse

(2010) Q.-H. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

(2010) Fernanda I. Staquicini et al.   JOURNAL OF CLINICAL INVESTIGATION

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

(2009) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

(2009) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels

(2009) P. S. Tsai et al.   JOURNAL OF NEUROSCIENCE

A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood-Brain Barrier and Provides Neuroprotection

(2009) H. Karatas et al.   JOURNAL OF NEUROSCIENCE

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Molecular Basis of the Core Structure of Tight Junctions

(2009) M. Furuse   Cold Spring Harbor Perspectives in Biology

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Vesicle Formation and Endocytosis: Function, Machinery, Mechanisms, and Modeling

(2008) Nihal S. Parkar et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

(2008) Sandrine Dauchy et al.   BIOCHEMICAL PHARMACOLOGY

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

(2008) Pietra Candela et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

Near Complete Rescue of Experimental Parkinson’s Disease with Intravenous, Non-viral GDNF Gene Therapy

(2008) Yun Zhang et al.   PHARMACEUTICAL RESEARCH