A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA

(2016) Federico Iovino et al.   JOURNAL OF CLINICAL INVESTIGATION

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

How Does Streptococcus pneumoniae Invade the Brain?

(2016) Federico Iovino et al.   TRENDS IN MICROBIOLOGY

Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

(2016) Xiangru Wang et al.   PLoS Pathogens

Exploring host-pathogen interactions through genome wide protein microarray analysis

(2016) Luigi Scietti et al.   Scientific Reports

A critical role for ATF2 transcription factor in the regulation of E-selectin expression in response to non-endotoxin components ofNeisseria meningitidis

(2015) M. C. Jacobsen et al.   CELLULAR MICROBIOLOGY

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

(2015) Brandon J. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Outer brain barriers in rat and human development

(2015) Christian B. Brøchner et al.   Frontiers in Neuroscience

Neisseria meningitidis; clones, carriage, and disease

(2014) R.C. Read   CLINICAL MICROBIOLOGY AND INFECTION

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

(2014) Samantha J. Dando et al.   CLINICAL MICROBIOLOGY REVIEWS

Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 1

(2014) Mariela Segura et al.   Future Microbiology

Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier

(2014) Federico Iovino et al.   INFECTION AND IMMUNITY

Identification of a Group B Streptococcal Fibronectin Binding Protein, SfbA, That Contributes to Invasion of Brain Endothelium and Development of Meningitis

(2014) R. Mu et al.   INFECTION AND IMMUNITY

The Role of Autophagy during Group BStreptococcusInfection of Blood-Brain Barrier Endothelium

(2014) Andrew S. Cutting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

(2014) Sandra C Bernard et al.   NATURE MEDICINE

Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor

(2014) Federico Iovino et al.   PLoS One

Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis

(2014) F. Alqahtani et al.   Open Biology

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells

(2014) Alexander Simonis et al.   PLoS Pathogens

Early sequence of events triggered by the interaction ofNeisseria meningitidiswith endothelial cells

(2013) Magali Soyer et al.   CELLULAR MICROBIOLOGY

Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease

(2013) Federico Iovino et al.   CELLULAR MICROBIOLOGY

A humanized model of microvascular infection

(2013) Keira Melican et al.   Future Microbiology

Meningococcal Interaction to Microvasculature Triggers the Tissular Lesions of Purpura Fulminans

(2013) Olivier Join-Lambert et al.   JOURNAL OF INFECTIOUS DISEASES

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein

(2013) Beth Mann et al.   JOURNAL OF INFECTIOUS DISEASES

Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes

(2013) Jon D. Laman et al.   Journal of Neuroimmune Pharmacology

Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis

(2013) Federico Iovino et al.   PLoS One

Brain Regulation of Thrombosis and Hemostasis

(2013) Mark J. Fisher   STROKE

Cytotoxic Necrotizing Factor 1 Contributes to Escherichia coli Meningitis

(2013) Ming-Hsien Wang et al.   Toxins

Genotypic and Phenotypic Traits That Distinguish Neonatal Meningitis-Associated Escherichia coli from Fecal E. coli Isolates of Healthy Human Hosts

(2012) Catherine M. Logue et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

IQGAP1 mediates the disruption of adherens junctions to promoteEscherichia coliK1 invasion of brain endothelial cells

(2012) Subramanian Krishnan et al.   CELLULAR MICROBIOLOGY

Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion Through the Remodeling of Endothelial Barriers

(2012) Nicolas Dupin et al.   CLINICAL INFECTIOUS DISEASES

Genetics and genomics in pediatric septic shock

(2012) Hector R. Wong   CRITICAL CARE MEDICINE

Cell Invasion by Neisseria meningitidis Requires a Functional Interplay between the Focal Adhesion Kinase, Src and Cortactin

(2012) Heiko Slanina et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Targeting of the central nervous system byListeria monocytogenes

(2012) Olivier Disson et al.   Virulence

Binding of Glycoprotein Srr1 of Streptococcus agalactiae to Fibrinogen Promotes Attachment to Brain Endothelium and the Development of Meningitis

(2012) Ho Seong Seo et al.   PLoS Pathogens

Neisseria meningitidisAdhesin NadA Targets β1 Integrins

(2011) Virginie Nägele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Meningitis in the United States, 1998–2007

(2011) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Posttranslational Modification of Pili upon Cell Contact Triggers N. meningitidis Dissemination

(2011) J. Chamot-Rooke et al.   SCIENCE

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration

(2011) Anirban Banerjee et al.   Nature Communications

Glycosaminoglycan Binding Facilitates Entry of a Bacterial Pathogen into Central Nervous Systems

(2011) Yung-Chi Chang et al.   PLoS Pathogens

Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium

(2010) Mathieu Coureuil et al.   CELL

NlpI Contributes to Escherichia coli K1 Strain RS218 Interaction with Human Brain Microvascular Endothelial Cells

(2010) C.-H. Teng et al.   INFECTION AND IMMUNITY

The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates

(2010) Asmaa Tazi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emergence of New VirulentNeisseria meningitidisSerogroup C Sequence Type 11 Isolates in France

(2010) Ala‐Eddine Deghmane et al.   JOURNAL OF INFECTIOUS DISEASES

The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion

(2010) Sarfraz A. Tunio et al.   MOLECULAR MICROBIOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neisseria meningitidis Opc Invasin Binds to the Sulphated Tyrosines of Activated Vitronectin to Attach to and Invade Human Brain Endothelial Cells

(2010) Claudia Sa E Cunha et al.   PLoS Pathogens

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

(2010) Alexandra Schubert-Unkmeir et al.   PLoS Pathogens

Pathogenesis of Central Nervous System Tuberculosis

(2009) Nicholas Be et al.   CURRENT MOLECULAR MEDICINE

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence

(2009) Odile B. Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

(2009) Mathieu Coureuil et al.   SCIENCE

Extracellular Bacterial Pathogen Induces Host Cell Surface Reorganization to Resist Shear Stress

(2009) Guillain Mikaty et al.   PLoS Pathogens

Ca2+/calmodulin-dependent invasion of microvascular endothelial cells of human brain by Escherichia coli K1

(2008) Yuri V. Kim et al.   CELL AND TISSUE RESEARCH

Polar bacterial invasion and translocation ofStreptococcus suisacross the blood-cerebrospinal fluid barrierin vitro

(2008) Tobias Tenenbaum et al.   CELLULAR MICROBIOLOGY

Recent advances in understanding the molecular basis of group B Streptococcus virulence

(2008) Heather C. Maisey et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1

(2008) A. Zelmer et al.   MICROBIOLOGY-SGM

Association of a Bacteriophage with Meningococcal Disease in Young Adults

(2008) Emmanuelle Bille et al.   PLoS One