VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

(2019) Linzhang Huang et al.   NATURE

Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging

(2018) Qiuyan Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

(2018) Joanna Kalucka et al.   Cell Metabolism

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney

(2016) Lars Muhl et al.   CELL AND TISSUE RESEARCH

PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B

(2016) Annika Mehlem et al.   DIABETES

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenic mutations causing glucose transport defects in GLUT1 transporter: The role of intermolecular forces in protein structure-function

(2015) Mobeen Raja et al.   BIOPHYSICAL CHEMISTRY

Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

(2015) Pieter Giesbertz et al.   DIABETOLOGIA

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1

(2015) Min-Sun Park   PLoS One

Statins Impair Glucose Uptake in Tumor Cells

(2015) Agata Malenda et al.   NEOPLASIA

Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell–cell adhesion

(2014) Werner Baumgartner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

(2014) Riikka Kivelä et al.   EMBO Molecular Medicine

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

(2014) Victor H. Guaiquil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

(2014) M. H. Dijkstra et al.   Scientific Reports

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function

(2013) Fitsum Guebre-Egziabher et al.   BIOCHIMIE

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Control of angiogenesis by AIBP-mediated cholesterol efflux

(2013) Longhou Fang et al.   NATURE

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

(2013) Carolina Hagberg et al.   PHYSIOLOGY

Tissue cholesterol content alterations in streptozotocin-induced diabetic rats

(2012) Xin-ting Wang et al.   ACTA PHARMACOLOGICA SINICA

Liver X Receptor Activation Reduces Angiogenesis by Impairing Lipid Raft Localization and Signaling of Vascular Endothelial Growth Factor Receptor-2

(2012) Alessio Noghero et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of Plasma Membrane Cholesterol Depletion on Glucose Transport Regulation in Leukemia Cells

(2012) Cristiana Caliceti et al.   PLoS One

The β-Chain of Cell Surface F 0 F 1 ATPase Modulates ApoA-I and HDL Transcytosis Through Aortic Endothelial Cells

(2011) Clara Cavelier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells

(2011) Pascale M. Ohnsorg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo

(2010) Ping-Pin Zheng et al.   ANNALS OF NEUROLOGY

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

(2010) Marko Kosicek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

(2010) Maija Bry et al.   CIRCULATION

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms

(2009) Johanna E. Lähteenvuo et al.   CIRCULATION

Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction

(2009) Lorena Zentilin et al.   FASEB JOURNAL

Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease

(2009) Torsten Falk et al.   Molecular Neurodegeneration

Mechanisms involved in cholesterol-induced neuronal insulin resistance

(2009) Changiz Taghibiglou et al.   NEUROPHARMACOLOGY

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

(2008) Francis Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins

(2008) B. Casar et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes

(2008) Josefin Skogsberg et al.   PLoS Genetics