Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

(2019) Benjamin D. S. Clarkson et al.   ANNALS OF NEUROLOGY

Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy

(2019) Gaetano Terrone et al.   EPILEPSY & BEHAVIOR

The P2X7 receptor: A main player in inflammation

(2018) Elena Adinolfi et al.   BIOCHEMICAL PHARMACOLOGY

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

(2018) Teresa Ravizza et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of aquaporin-4 in synaptic plasticity, memory and disease

(2018) Jacqueline A. Hubbard et al.   BRAIN RESEARCH BULLETIN

Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows

(2018) Duc-Loc Nguyen et al.   EPILEPSIA

Epilepsy is a neurological and a systemic disorder

(2018) Alan W.C. Yuen et al.   EPILEPSY & BEHAVIOR

Upregulation of HMGB1-TLR4 inflammatory pathway in focal cortical dysplasia type II

(2018) Zhongbin Zhang et al.   Journal of Neuroinflammation

Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade

(2018) Allen D. DeSena et al.   Journal of Neuroinflammation

Astrocytes and Glutamine Synthetase in Epileptogenesis

(2018) Tore Eid et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

(2018) E. A. van Vliet et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy

(2018) Theodor Rüber et al.   BRAIN

Tocilizumab treatment for new onset refractory status epilepticus

(2018) Jin-Sun Jun et al.   ANNALS OF NEUROLOGY

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

(2018) Andrea Arena et al.   BRAIN PATHOLOGY

Clinical studies and anti-inflammatory mechanisms of treatments

(2017) Jacqueline A. French et al.   EPILEPSIA

Innate and adaptive immunity in human epilepsies

(2017) Jan Bauer et al.   EPILEPSIA

Neurobehavioral comorbidities of epilepsy: Role of inflammation

(2017) Andrey M. Mazarati et al.   EPILEPSIA

Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury

(2017) William B. Gallentine et al.   EPILEPSIA

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

(2017) Pavel Klein et al.   EPILEPSIA

Neuroinflammation imaging markers for epileptogenesis

(2017) Matthias J. Koepp et al.   EPILEPSIA

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

(2017) Gaetano Terrone et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Epilepsy and astrocyte energy metabolism

(2017) Detlev Boison et al.   GLIA

Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Ketone Bodies as Anti-Seizure Agents

(2017) Timothy A. Simeone et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress Contributes to Status Epilepticus Associated Mortality

(2017) Jennifer N. Pearson-Smith et al.   NEUROCHEMICAL RESEARCH

Febrile infection-related epilepsy syndrome treated with anakinra

(2016) Daniel L. Kenney-Jung et al.   ANNALS OF NEUROLOGY

Recent advances in status epilepticus

(2016) Eugen Trinka et al.   CURRENT OPINION IN NEUROLOGY

Omega-3 Fatty Acids in the Management of Epilepsy

(2016) Silvia Tejada et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transient and chronic seizure-induced inflammation in human focal epilepsy

(2016) Tracy Butler et al.   EPILEPSIA

WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities

(2016) Teresa Ravizza et al.   EPILEPSIA

Anti-tumor necrosis factor alpha therapy (adalimumab) in Rasmussen's encephalitis: An open pilot study

(2016) Stanislas Lagarde et al.   EPILEPSIA

Upregulation of HMGB1, toll-like receptor and RAGE in human Rasmussen’s encephalitis

(2016) Guoming Luan et al.   EPILEPSY RESEARCH

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

(2016) A. Fuso et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Brain inflammation is accompanied by peripheral inflammation in Cstb −/− mice, a model for progressive myoclonus epilepsy

(2016) Olesya Okuneva et al.   Journal of Neuroinflammation

Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

(2016) Fei-Ji Sun et al.   Journal of Neuroinflammation

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

(2016) Alba Jimenez-Pacheco et al.   JOURNAL OF NEUROSCIENCE

Advances in the development of biomarkers for epilepsy

(2016) Asla Pitkänen et al.   LANCET NEUROLOGY

Inflammatory Response in the CNS: Friend or Foe?

(2016) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy

(2016) Rosaria Pascente et al.   NEUROBIOLOGY OF DISEASE

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

(2016) Sreekanth Puttachary et al.   NEUROBIOLOGY OF DISEASE

P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy

(2016) Halima Amhaoul et al.   NEUROPHARMACOLOGY

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

(2016) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice

(2016) Zheng-Hao Xu et al.   NEUROSCIENCE

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures

(2016) Yuki Sugaya et al.   Cell Reports

Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates

(2015) N. Patel et al.   BIOCONJUGATE CHEMISTRY

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy

(2015) Jennifer N. Pearson et al.   NEUROBIOLOGY OF DISEASE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

(2015) Cristina Roseti et al.   NEUROBIOLOGY OF DISEASE

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective

(2015) S. Williams et al.   NEUROSCIENCE

Role of Toll-like receptor/MYD88 signaling in neurodegenerative diseases

(2015) Wang Xiang et al.   REVIEWS IN THE NEUROSCIENCES

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Hippocampal Neuro-Networks and Dendritic Spine Perturbations in Epileptogenesis Are Attenuated by Neuroprotectin D1

(2015) Alberto E. Musto et al.   PLoS One

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

(2014) Emilio Russo et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats

(2014) Zsolt Kovács et al.   BRAIN RESEARCH BULLETIN

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2014) Matthew L. Diamond et al.   EPILEPSIA

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures

(2014) Lauren Walker et al.   LANCET

Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance

(2014) E.A. van Vliet et al.   NEUROSCIENCE

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

(2014) Andres M. Kanner et al.   Neurotherapeutics

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy

(2013) Manuela Mazzuferi et al.   ANNALS OF NEUROLOGY

Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study

(2013) Darrell V. Lewis et al.   ANNALS OF NEUROLOGY

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of oxidative stress during inflammatory processes

(2013) Jérôme Lugrin et al.   BIOLOGICAL CHEMISTRY

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death

(2013) Jin Hee Kim et al.   BRAIN RESEARCH

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Does aspirin use make it harder to collect seizures during elective video-EEG telemetry?

(2013) Rachel M. Godfred et al.   EPILEPSY & BEHAVIOR

Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis

(2013) Vijay Ramaswamy et al.   Journal of Neuroinflammation

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Rasmussen encephalitis treated with natalizumab

(2013) S. Bittner et al.   NEUROLOGY

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue

(2013) Katharina Pernhorst et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The TARC/sICAM5 Ratio in Patient Plasma is a Candidate Biomarker for Drug Resistant Epilepsy

(2013) John R. Pollard et al.   Frontiers in Neurology

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

(2012) C. G. Bien et al.   BRAIN

Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation

(2012) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury

(2012) Ke-Yi Wang et al.   CLINICA CHIMICA ACTA

Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology

(2012) Federica Frigerio et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Aspirin Use in Sturge-Weber Syndrome

(2012) Eboni I. Lance et al.   JOURNAL OF CHILD NEUROLOGY

Increased In Vivo Expression of an Inflammatory Marker in Temporal Lobe Epilepsy

(2012) J. Hirvonen et al.   JOURNAL OF NUCLEAR MEDICINE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent

(2012) Ben A. Duffy et al.   NEUROIMAGE

Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy

(2012) M. Nowak et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Brain inflammation as a biomarker in epilepsy

(2011) Annamaria Vezzani et al.   Biomarkers in Medicine

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis

(2011) Alberto E. Musto et al.   EPILEPSIA

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

Cytokines and brain excitability

(2011) Michael A. Galic et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Survey of Aspirin Use in Sturge-Weber Syndrome

(2011) Mihee J. Bay et al.   JOURNAL OF CHILD NEUROLOGY

Imaging Inflammation in a Patient with Epilepsy Due to Focal Cortical Dysplasia

(2011) Tracy Butler et al.   JOURNAL OF NEUROIMAGING

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

(2011) Demet Akin et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report

(2010) Stefano Sotgiu et al.   BMC Neurology

Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias

(2010) Anand Iyer et al.   EPILEPSIA

Polyunsaturated fatty acids and epilepsy

(2010) Ameer Y. Taha et al.   EPILEPSIA

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

Resolvin E1 Improves Tear Production and Decreases Inflammation in a Dry Eye Mouse Model

(2010) Na Li et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Cystatin B Deficiency Sensitizes Neurons to Oxidative Stress in Progressive Myoclonus Epilepsy, EPM1

(2009) M. K. Lehtinen et al.   JOURNAL OF NEUROSCIENCE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

Involvement of endogenous prostaglandin F2α on kainic acid-induced seizure activity through FP receptor: The mechanism of proconvulsant effects of COX-2 inhibitors

(2008) Hee-Jae Kim et al.   BRAIN RESEARCH

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Role of Brain Inflammation in Epileptogenesis

(2008) Jieun Choi et al.   YONSEI MEDICAL JOURNAL

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE