Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

Age-dependent changes at the blood-brain barrier. A Comparative structural and functional study in young adult and middle aged rats

(2018) Luca Bors et al.   BRAIN RESEARCH BULLETIN

Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

(2018) Sofia Gustafsson et al.   NEUROPHARMACOLOGY

Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier

(2017) Doreen Osgood et al.   NEUROBIOLOGY OF AGING

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

(2016) Loqman A. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier

(2016) M Bauer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter

(2016) Pavitra Kannan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier

(2015) RM Raaphorst et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

(2015) Martin Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography

(2015) Thomas Wanek et al.   MOLECULAR PHARMACEUTICS

Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects

(2014) Jens Pahnke et al.   ARCHIVES OF MEDICAL RESEARCH

1 ,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-  Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

(2014) M. R. Durk et al.   JOURNAL OF NEUROSCIENCE

Increased Permeability-Glycoprotein Inhibition at the Human Blood-Brain Barrier Can Be Safely Achieved by Performing PET During Peak Plasma Concentrations of Tariquidar

(2014) W. C. Kreisl et al.   JOURNAL OF NUCLEAR MEDICINE

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

St. John's Wort Reduces Beta-Amyloid Accumulation in a Double Transgenic Alzheimer's Disease Mouse Model-Role of P-Glycoprotein

(2013) Anja Brenn et al.   BRAIN PATHOLOGY

Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice

(2013) Jacqueline Hofrichter et al.   Current Alzheimer Research

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier

(2013) Thomas Wanek et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

(2013) Maria Feldmann et al.   LANCET NEUROLOGY

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

(2013) Anna Carrano et al.   NEUROBIOLOGY OF AGING

Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer’s Disease

(2013) Dharmini C. Mehta et al.   PHARMACEUTICAL RESEARCH

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender

(2012) Daniëlle M. E. van Assema et al.   MOLECULAR IMAGING AND BIOLOGY

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier

(2011) J. P. Bankstahl et al.   JOURNAL OF NEUROSCIENCE

ABC efflux transporters in brain vasculature of Alzheimer's subjects

(2010) Hasini C. Wijesuriya et al.   BRAIN RESEARCH

Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy

(2010) Hero Bartmann et al.   EPILEPSIA

Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging

(2010) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis

(2010) Brian Jeynes et al.   NEUROSCIENCE LETTERS

Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications

(2009) P Kannan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET

(2009) Martin Bauer et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

(2009) Claudia Kuntner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood-Brain Barrier with (R)-11C-Verapamil and PET

(2009) C. C. Wagner et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans

(2009) M. Muzi et al.   JOURNAL OF NUCLEAR MEDICINE

Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar

(2009) Christian la Fougère et al.   NEUROIMAGE

Alzheimer's disease and blood–brain barrier function—Why have anti-β-amyloid therapies failed to prevent dementia progression?

(2009) Jens Pahnke et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

P-Glycoprotein Function at the Blood-Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys

(2008) J.-S. Liow et al.   JOURNAL OF NUCLEAR MEDICINE

Blood–brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration

(2008) Anna L. Bartels et al.   NEUROBIOLOGY OF AGING