Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review

(2013) Patrycja Kleczkowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spinal NTS2 receptor activation reverses signs of neuropathic pain

(2013) Pascal Tétreault et al.   FASEB JOURNAL

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model

(2012) Louis Doré-Savard et al.   CLINICAL & EXPERIMENTAL METASTASIS

Blood-Brain Barrier Transport of Drugs for the Treatment of Brain Diseases

(2012) Reinhard Gabathuler   CNS & Neurological Disorders-Drug Targets

Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris

(2012) Anthony Fernandez-Castaneda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Translational Investigation and Treatment of Neuropathic Pain

(2012) Bo Xu et al.   Molecular Pain

Analgesic synergy of neurotensin receptor subtype 2 agonist NT79 and morphine

(2011) Mona Boules et al.   BEHAVIOURAL PHARMACOLOGY

Peptide therapeutics for CNS indications

(2011) Paul McGonigle   BIOCHEMICAL PHARMACOLOGY

Bone health management in patients with breast cancer: Current standards and emerging strategies

(2011) Matti S. Aapro et al.   BREAST

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

(2011) Y Bertrand et al.   BRITISH JOURNAL OF CANCER

Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

(2011) Alexandre Murza et al.   ChemMedChem

Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain

(2011) A. Guillemette et al.   EUROPEAN JOURNAL OF PAIN

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

(2011) R. Kurzrock et al.   MOLECULAR CANCER THERAPEUTICS

The Development of New Analgesics Over the Past 50 Years: A Lack of Real Breakthrough Drugs

(2010) Igor Kissin   ANESTHESIA AND ANALGESIA

Multiplexing of Multicolor Bioluminescence Resonance Energy Transfer

(2010) Billy Breton et al.   BIOPHYSICAL JOURNAL

Biopharmaceutical drug targeting to the brain

(2010) William M. Pardridge   JOURNAL OF DRUG TARGETING

Identification and Functional Characterization of a Stable, Centrally Active Derivative of the Neurotensin (8−13) Fragment as a Potential First-in-Class Analgesic

(2010) Francis M. Hughes et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration

(2010) Christian Ché et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systemically and Topically Active Antinociceptive Neurotensin Compounds

(2010) G. C. Rossi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PK20, a New Opioid-Neurotensin Hybrid Peptide That Exhibits Central and Peripheral Antinociceptive Effects

(2010) Patrycja Kleczkowska et al.   Molecular Pain

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

(2010) C. Koole et al.   MOLECULAR PHARMACOLOGY

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

Altered morphine-induced analgesia in neurotensin type 1 receptor null mice

(2010) G. Roussy et al.   NEUROSCIENCE

Behavioral, Medical Imaging and Histopathological Features of a New Rat Model of Bone Cancer Pain

(2010) Louis Doré-Savard et al.   PLoS One

NT69L, a novel analgesic, shows synergy with morphine

(2009) M. Boules et al.   BRAIN RESEARCH

NT79: A novel neurotensin analog with selective behavioral effects

(2009) Mona Boules et al.   BRAIN RESEARCH

Transport characteristics of a novel peptide platform for CNS therapeutics

(2009) Yanick Bertrand et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparison of N-Terminal Modifications on Neurotensin(8−13) Analogues Correlates Peptide Stability but Not Binding Affinity with in Vivo Efficacy

(2009) Kevin S. Orwig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Involvement of NTS2 receptors in stress-induced analgesia

(2009) M. Lafrance et al.   NEUROSCIENCE

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

(2008) A Régina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Biological Effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a New Analogue of Neurotensin that Crosses the Blood−Brain Barrier

(2008) Pierre Bredeloux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model

(2008) Geneviève Roussy et al.   JOURNAL OF NEUROCHEMISTRY

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS