Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex

(2017) William E. Allen et al.   NEURON

Targeting Neural Circuits

(2016) Priyamvada Rajasethupathy et al.   CELL

High-Throughput, High-Resolution Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing

(2016) Takayasu Mikuni et al.   CELL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Brain endothelial cell‐targeted gene therapy of neurovascular disorders

(2016) Serena Marchiò et al.   EMBO Molecular Medicine

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases

(2016) Michaël Hocquemiller et al.   HUMAN GENE THERAPY

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

(2016) Jean Bennett et al.   LANCET

Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector

(2016) Sourav R Choudhury et al.   MOLECULAR THERAPY

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

(2016) Yang Yang et al.   NATURE BIOTECHNOLOGY

Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain

(2016) Christina K Kim et al.   NATURE METHODS

Genetically encoded indicators of neuronal activity

(2016) Michael Z Lin et al.   NATURE NEUROSCIENCE

A viral strategy for targeting and manipulating interneurons across vertebrate species

(2016) Jordane Dimidschstein et al.   NATURE NEUROSCIENCE

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

rAAV-compatible MiniPromoters for restricted expression in the brain and eye

(2016) Charles N. de Leeuw et al.   Molecular Brain

A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging

(2016) Nicholas James Sofroniew et al.   eLife

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective

(2015) Eric Hastie et al.   HUMAN GENE THERAPY

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

ScaleS: an optical clearing palette for biological imaging

(2015) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

(2015) Mark A G Eldridge et al.   NATURE NEUROSCIENCE

Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules

(2015) A. Wertz et al.   SCIENCE

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice

(2014) Shrivats Mohan Iyer et al.   NATURE BIOTECHNOLOGY

Multiplex Cell and Lineage Tracking with Combinatorial Labels

(2014) Karine Loulier et al.   NEURON

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice

(2014) Sara E. Gombash et al.   Frontiers in Molecular Neuroscience

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

(2014) R. Jude Samulski et al.   Annual Review of Virology

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion

(2013) G Fischer et al.   GENE THERAPY

A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum

(2013) Nathan C Shaner et al.   NATURE METHODS

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

Olfactory cortical neurons read out a relative time code in the olfactory bulb

(2013) Rafi Haddad et al.   NATURE NEUROSCIENCE

Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience

(2013) Ruchi Parekh et al.   NEURON

Virus-mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain

(2012) Omar A Samad et al.   MOLECULAR THERAPY

Improving FRET dynamic range with bright green and red fluorescent proteins

(2012) Amy J Lam et al.   NATURE METHODS

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits

(2011) J. Nicholas Betley et al.   HUMAN GENE THERAPY

Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer

(2011) Nagesh Pulicherla et al.   MOLECULAR THERAPY

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Single-Synapse Analysis of a Diverse Synapse Population: Proteomic Imaging Methods and Markers

(2010) Kristina D. Micheva et al.   NEURON

Targeting Single Neuronal Networks for Gene Expression and Cell Labeling In Vivo

(2010) James H. Marshel et al.   NEURON

New Mouse Lines for the Analysis of Neuronal Morphology Using CreER(T)/loxP-Directed Sparse Labeling

(2009) Tudor C. Badea et al.   PLoS One

Short promoters in viral vectors drive selective expression in mammalian inhibitory neurons, but do not restrict activity to specific inhibitory cell-types

(2009) Jason L. Nathanson   Frontiers in Neural Circuits

Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter

(2008) M S Oh et al.   GENE THERAPY

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice

(2008) Paul Young et al.   NATURE NEUROSCIENCE