The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors

3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

(2019) Fanben Meng et al.   ADVANCED MATERIALS

In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity

(2019) Alican Ozkan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic Formation of Hydrogel Microcapsules with a Single Aqueous Core by Spontaneous Cross-linking in Aqueous Two-Phase System (ATPS) Droplets

(2019) Takaichi Watanabe et al.   LANGMUIR

Molecular landmarks of tumor hypoxia across cancer types

(2019) Vinayak Bhandari et al.   NATURE GENETICS

Bioprinting of 3D breast epithelial spheroids for human cancer models

(2019) Swathi Swaminathan et al.   Biofabrication

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma

(2019) Özge Şükrüoğlu Erdoğan et al.   Biomed Research International

Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept

(2019) Noelia Campillo et al.   Frontiers in Oncology

Biofabrication strategies for creating microvascular complexity

(2019) Alisa Morss-Clyne et al.   Biofabrication

Preparation and characterization of size-controlled glioma spheroids using agarose hydrogel microwells

(2019) Fereshtehsadat Mirab et al.   PLoS One

Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

(2019) Yi Zhao et al.   MOLECULES

Anticancer drug discovery using multicellular tumor spheroid models

(2019) Michele Zanoni et al.   Expert Opinion on Drug Discovery

Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model

(2019) Margaux Duchamp et al.   Biotechnology Journal

Design of spherically structured 3D in vitro tumor models -Advances and prospects

(2018) L.P. Ferreira et al.   Acta Biomaterialia

Hybrid collagen alginate hydrogel as a platform for 3D tumor spheroid invasion

(2018) Chun Liu et al.   Acta Biomaterialia

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

(2018) A. Boussommier-Calleja et al.   BIOMATERIALS

Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids

(2018) Kuang Hong Neoh et al.   BIOMATERIALS

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Co-culture of tumor spheroids and monocytes in a collagen matrix-embedded microfluidic device to study the migration of breast cancer cells

(2018) Tianying Yuan et al.   CHINESE CHEMICAL LETTERS

Cancer incidence and mortality in China, 2014

(2018) Wanqing Chen et al.   Chinese Journal of Cancer Research

Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

(2018) Tatsuya Osaki et al.   CURRENT OPINION IN BIOTECHNOLOGY

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Mass fabrication of uniform sized 3D tumor spheroid using high-throughput microfluidic system

(2018) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance

(2018) Ji-Hyun Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

(2018) Khashayar Moshksayan et al.   SENSORS AND ACTUATORS B-CHEMICAL

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

(2018) Supriya Nagaraju et al.   Advanced Healthcare Materials

Chaotic printing: using chaos to fabricate densely packed micro- and nanostructures at high resolution and speed

(2018) Grissel Trujillo-de Santiago et al.   Materials Horizons

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis

(2018) Chris P. Miller et al.   NEOPLASIA

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

(2018) Gianpiero Lazzari et al.   Acta Biomaterialia

Multiscale bioprinting of vascularized models

(2018) Amir K. Miri et al.   BIOMATERIALS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

(2018) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

(2018) Theresa Mulholland et al.   Scientific Reports

Versatile Fabrication of Size- and Shape-Controllable Nanofibrous Concave Microwells for Cell Spheroid Formation

(2018) Sang Min Park et al.   ACS Applied Materials & Interfaces

Early stage mechanical remodeling of collagen surrounding head and neck squamous cell carcinoma spheroids correlates strongly with their invasion capability

(2018) Yin-Quan Chen et al.   Acta Biomaterialia

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

(2018) Ana S. Nunes et al.   BIOTECHNOLOGY AND BIOENGINEERING

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

Development of three-dimensional (3D) spheroid cultures of the continuous rainbow trout liver cell line RTL-W1

(2018) Tobias Lammel et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture

(2018) Kelly M. Hainline et al.   MACROMOLECULAR BIOSCIENCE

A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy

(2018) Wanyoung Lim et al.   MOLECULES

Accelerating anticancer drug development — opportunities and trade-offs

(2018) Sharyl J. Nass et al.   Nature Reviews Clinical Oncology

Subcutaneous Inoculation of 3D Pancreatic Cancer Spheroids Results in Development of Reproducible Stroma-Rich Tumors

(2018) Mikhail Durymanov et al.   Translational Oncology

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines

(2018) Jiho Song et al.   Scientific Reports

Microfluidic Formation of Coculture Tumor Spheroids with Stromal Cells As a Novel 3D Tumor Model for Drug Testing

(2018) Qi Sun et al.   ACS Biomaterials-Science & Engineering

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

(2018) Ying Wang et al.   ACS Biomaterials-Science & Engineering

Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release

(2018) Pooja Sabhachandani et al.   JOURNAL OF CONTROLLED RELEASE

Spontaneous formation of tumor spheroid on a hydrophilic filter paper for cancer stem cell enrichment

(2018) Jing Jing Fu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Time series assessment of the effects of hypoxic stress on glioma tumorsphere development within engineered microscale niches

(2018) Junghwa Cha et al.   BIOMATERIALS

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional cell culture models for anticancer drug screening: Worth the effort?

(2017) Eddy-Tim Verjans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Cell migration in microengineered tumor environments

(2017) Eujin Um et al.   LAB ON A CHIP

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

(2017) Robert G. Mannino et al.   LAB ON A CHIP

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Nanoparticles Penetrate into the Multicellular Spheroid-on-Chip: Effect of Surface Charge, Protein Corona, and Exterior Flow

(2017) Ke Huang et al.   MOLECULAR PHARMACEUTICS

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

(2017) Altug Ozcelikkale et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

(2017) Yuan Tang et al.   Scientific Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Spheroids Formation on Non-Adhesive Surfaces by Liquid Overlay Technique: Considerations and Practical Approaches

(2017) Elisabete C. Costa et al.   Biotechnology Journal

The Emerging Frontiers and Applications of High-Resolution 3D Printing

(2017) Mao Mao et al.   Micromachines

Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment

(2017) Angela Babetski Holton et al.   PLoS One

Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers

(2017) Xingliang Dai et al.   Scientific Reports

A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments

(2017) Yuta Ando et al.   Scientific Reports

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

(2016) Xuan Zhou et al.   ACS Applied Materials & Interfaces

Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids

(2016) Christian Siltanen et al.   Acta Biomaterialia

Rapid Continuous Multimaterial Extrusion Bioprinting

(2016) Wanjun Liu et al.   ADVANCED MATERIALS

Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments

(2016) Mary C. Regier et al.   BIOMEDICAL MICRODEVICES

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

The ethics of animal research: a survey of the public and scientists in North America

(2016) Ari R. Joffe et al.   BMC Medical Ethics

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

(2016) Bumsoo Han et al.   CANCER LETTERS

Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression

(2016) Manjulata Singh et al.   CANCER RESEARCH

Tumor spheroid assembly on hyaluronic acid-based structures: A review

(2016) Marco P. Carvalho et al.   CARBOHYDRATE POLYMERS

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

(2016) Alexandra S. Piotrowski-Daspit et al.   Integrative Biology

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

Digital microfluidics for spheroid-based invasion assays

(2016) Brian F. Bender et al.   LAB ON A CHIP

A lab-on-a-chip device for investigating the fusion process of olfactory ensheathing cell spheroids

(2016) Ahmed Munaz et al.   LAB ON A CHIP

Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform

(2016) Aereas Aung et al.   LAB ON A CHIP

Rapid formation of size-controllable multicellular spheroids via 3D acoustic tweezers

(2016) Kejie Chen et al.   LAB ON A CHIP

Generation and functional assessment of 3D multicellular spheroids in droplet based microfluidics platform

(2016) P. Sabhachandani et al.   LAB ON A CHIP

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Agarose multi-wells for tumour spheroid formation and anti-cancer drug test

(2016) Yadong Tang et al.   MICROELECTRONIC ENGINEERING

Limits to Personalized Cancer Medicine

(2016) Ian F. Tannock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro

(2016) Monika Dubiak-Szepietowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

An Engineered Breast Cancer Model on a Chip to Replicate ECM-Activation In Vitro during Tumor Progression

(2016) Filomena Gioiella et al.   Advanced Healthcare Materials

Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review

(2016) Navid Kashaninejad et al.   Micromachines

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials-Science & Engineering

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials Science & Engineering

Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment

(2016) B. L. Khoo et al.   Science Advances

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

(2015) Kan Yue et al.   BIOMATERIALS

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

(2015) Jin-Young Kim et al.   JOURNAL OF BIOTECHNOLOGY

Proteomics analysis of E-cadherin knockdown in epithelial breast cancer cells

(2015) Daniele Vergara et al.   JOURNAL OF BIOTECHNOLOGY

Adding the ‘heart’ to hanging drop networks for microphysiological multi-tissue experiments

(2015) Saeed Rismani Yazdi et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells

(2015) Xue-Ying Wang et al.   LAB ON A CHIP

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Engineering cancer microenvironments for in vitro 3-D tumor models

(2015) Waseem Asghar et al.   Materials Today

Translational value of mouse models in oncology drug development

(2015) Stephen E Gould et al.   NATURE MEDICINE

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment

(2015) Jing Bai et al.   Oncotarget

A bladder cancer microenvironment simulation system based on a microfluidic co-culture model

(2015) Peng-fei Liu et al.   Oncotarget

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

(2015) Jing Bai et al.   Oncotarget

Stretching Fibroblasts Remodels Fibronectin and Alters Cancer Cell Migration

(2015) Mingfang Ao et al.   Scientific Reports

Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing

(2015) Jorge M Santos et al.   Stem Cell Research & Therapy

Bioprinting-Based High-Throughput Fabrication of Three-Dimensional MCF-7 Human Breast Cancer Cellular Spheroids

(2015) Kai Ling et al.   Engineering

Modulation of Huh7.5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness

(2015) Bae Hoon Lee et al.   PLoS One

Enrichment of the Cancer Stem Phenotype in Sphere Cultures of Prostate Cancer Cell Lines Occurs through Activation of Developmental Pathways Mediated by the Transcriptional Regulator ΔNp63α

(2015) Roberto Portillo-Lara et al.   PLoS One

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model

(2015) Zhuo Zhang et al.   Oncotarget

Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system

(2014) Elke Kaemmerer et al.   Acta Biomaterialia

Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

(2014) Zeynep Dereli-Korkut et al.   ANALYTICAL CHEMISTRY

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

A microfluidic co-culture system to monitor tumor-stromal interactions on a chip

(2014) Nishanth V. Menon et al.   Biomicrofluidics

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

(2014) Hyunjae Lee et al.   Biomicrofluidics

A microfluidic model for organ-specific extravasation of circulating tumor cells

(2014) R. Riahi et al.   Biomicrofluidics

Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models

(2014) Elisabete C. Costa et al.   BIOTECHNOLOGY AND BIOENGINEERING

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors

(2014) Can Sarisozen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

(2014) Christopher Heylman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip

(2014) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

Continuous flow micro-bioreactors for the production of biopharmaceuticals: the effect of geometry, surface texture, and flow rate

(2014) Lucía D. Garza-García et al.   LAB ON A CHIP

A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

(2014) Janine Ruppen et al.   LAB ON A CHIP

Development of a Magnetic 3D Spheroid Platform with Potential Application for High-Throughput Drug Screening

(2014) Wei Mei Guo et al.   MOLECULAR PHARMACEUTICS

Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel

(2014) Josephine Y. Fang et al.   PLoS One

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional printing of Hela cells for cervical tumor modelin vitro

(2014) Yu Zhao et al.   Biofabrication

A microfluidic chip with a U-shaped microstructure array for multicellular spheroid formation, culturing and analysis

(2014) Chien-Yu Fu et al.   Biofabrication

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

(2014) Mostafa Sefidgar et al.   Journal of Biological Engineering

High-throughput generation of spheroids using magnetic nanoparticles for three-dimensional cell culture

(2013) Jeong Ah Kim et al.   BIOMATERIALS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics

(2013) Ching-Te Kuo et al.   BIOMATERIALS

Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

(2013) Kristie M. Charoen et al.   BIOMATERIALS

Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells

(2013) Sara I. Montanez-Sauri et al.   Integrative Biology

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

(2013) Michelle B. Chen et al.   Integrative Biology

Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain

(2013) Jiun-Wei Huang et al.   LAB ON A CHIP

Microfluidic titer plate for stratified 3D cell culture

(2013) Sebastiaan J. Trietsch et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug

(2013) Crystal S. Shin et al.   MOLECULAR PHARMACEUTICS

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Analysis of Radiation-Induced Cell Death in Head and Neck Squamous Cell Carcinoma and Rat Liver Maintained in Microfluidic Devices

(2013) Simon D. Carr et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device

(2013) Shanshan Wang et al.   PLoS One

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Functional Investigation of NCI-H460-Inducible Myofibroblasts on the Chemoresistance to VP-16 with a Microfluidic 3D Co-Culture Device

(2013) Yuanyuan Hao et al.   PLoS One

Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin

(2013) Juan Manuel Iglesias et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment

(2013) Hon Fai Chan et al.   Scientific Reports

Development of Microfluidic-based Analytical Methodology for Studying the Effects of Chemotherapy Agents on Cancer Tissue

(2012) Deborah Sylvester et al.   Current Analytical Chemistry

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a three-dimensional microfluidic system for long-term tumor spheroid culture

(2012) Karina Ziółkowska et al.   SENSORS AND ACTUATORS B-CHEMICAL

Effect of tumor shape and size on drug delivery to solid tumors

(2012) M Soltani et al.   Journal of Biological Engineering

Cancer Cells Regulate Biomechanical Properties of Human Microvascular Endothelial Cells

(2011) Claudia Tanja Mierke   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

(2011) Yung-Ann Chen et al.   LAB ON A CHIP

The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy

(2011) Xinran Xiang et al.   PLoS One

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic experimental platform for producing size-controlled three-dimensional spheroids

(2011) Hiroki Ota et al.   SENSORS AND ACTUATORS A-PHYSICAL

Generation and manipulation of magnetic multicellular spheroids

(2010) Vincent H.B. Ho et al.   BIOMATERIALS

Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening

(2010) Michael C. W. Chen et al.   BIOMEDICAL MICRODEVICES

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Finding the tumor copycat: Approximating a human cancer

(2010) Terry Van Dyke   NATURE MEDICINE

Finding the tumor copycat: Therapy fails, patients don't

(2010) Lee M Ellis et al.   NATURE MEDICINE

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

A Hollow Sphere Soft Lithography Approach for Long-Term Hanging Drop Methods

(2009) Won Gu Lee et al.   TISSUE ENGINEERING PART C-METHODS