Advances in multicellular spheroids formation

3D scaffolds in breast cancer research

(2016) Girdhari Rijal et al.   BIOMATERIALS

Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells

(2016) Pertteli Salmenperä et al.   EXPERIMENTAL CELL RESEARCH

Rapid formation of size-controllable multicellular spheroids via 3D acoustic tweezers

(2016) Kejie Chen et al.   LAB ON A CHIP

Developing multi-cellular tumor spheroid model (MCTS) in the chitosan/collagen/alginate (CCA) fibrous scaffold for anticancer drug screening

(2016) Jian-Zheng Wang et al.   Materials Science & Engineering C-Materials for Biological Applications

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro

(2016) Monika Dubiak-Szepietowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rapid Enhancement of Cellular Spheroid Assembly by Acoustically Driven Microcentrifugation

(2016) Layla Alhasan et al.   ACS Biomaterials-Science & Engineering

Modeling tumor microenvironments using custom-designed biomaterial scaffolds

(2016) Zen Liu et al.   Current Opinion in Chemical Engineering

Rapid Enhancement of Cellular Spheroid Assembly by Acoustically Driven Microcentrifugation

(2016) Layla Alhasan et al.   ACS Biomaterials Science & Engineering

3D Porous Chitosan–Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer

(2015) Kui Wang et al.   BIOMACROMOLECULES

In-situ birth of MSCs multicellular spheroids in poly( l -glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration

(2015) Kunxi Zhang et al.   BIOMATERIALS

Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway

(2015) Yunhong Tian et al.   BMC CANCER

Effect of particle size in a colloidal hydrogel scaffold for 3D cell culture

(2015) Jianjun Gu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cell-sized condensed collagen microparticles for preparing microengineered composite spheroids of primary hepatocytes

(2015) Masumi Yamada et al.   LAB ON A CHIP

Engineering cancer microenvironments for in vitro 3-D tumor models

(2015) Waseem Asghar et al.   Materials Today

Chitosan as inter-cellular linker to accelerate multicellular spheroid generation in hydrogel scaffold

(2015) Yang Liu et al.   POLYMER

Development of Poly(Ethylene Glycol) Hydrogels for Salivary Gland Tissue Engineering Applications

(2015) Andrew D. Shubin et al.   TISSUE ENGINEERING PART A

Three-Dimensional Neural Spheroid Culture: AnIn VitroModel for Cortical Studies

(2015) Yu-Ting L. Dingle et al.   TISSUE ENGINEERING PART C-METHODS

Modulation of Huh7.5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness

(2015) Bae Hoon Lee et al.   PLoS One

Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

(2015) Xue Gong et al.   PLoS One

Superhydrophobic Chips for Cell Spheroids High-Throughput Generation and Drug Screening

(2014) Mariana B. Oliveira et al.   ACS Applied Materials & Interfaces

Galactosylated reversible hydrogels as scaffold for HepG2 spheroid generation

(2014) Yuhan Wu et al.   Acta Biomaterialia

Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing

(2014) Yaolei Wang et al.   ANALYST

Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice

(2014) Ferdinand Ruedinger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Hydrogel Thin Film with Swelling-Induced Wrinkling Patterns for High-Throughput Generation of Multicellular Spheroids

(2014) Ziqi Zhao et al.   BIOMACROMOLECULES

Cell encapsulation via microtechnologies

(2014) AhRan Kang et al.   BIOMATERIALS

Human mesenchymal stem cell spheroids in fibrin hydrogels exhibit improved cell survival and potential for bone healing

(2014) Kaitlin C. Murphy et al.   CELL AND TISSUE RESEARCH

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges

(2014) Sara I. Montanez-Sauri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening

(2014) K. Kwapiszewska et al.   LAB ON A CHIP

Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel

(2014) Josephine Y. Fang et al.   PLoS One

Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

(2013) B.D. Walters et al.   Acta Biomaterialia

Application of open porous poly(D,L-lactide-co-glycolide) microspheres and the strategy of hydrophobic seeding in hepatic tissue cultivation

(2013) Ming-Ju Chou et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Droplet-based microfluidic system to form and separate multicellular spheroids using magnetic nanoparticles

(2013) Sungjun Yoon et al.   LAB ON A CHIP

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

(2013) E. L. S. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

(2013) Y. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment

(2013) Hon Fai Chan et al.   Scientific Reports

A Non-Mulberry Silk Fibroin Protein Based 3D In Vitro Tumor Model for Evaluation of Anticancer Drug Activity

(2012) Sarmistha Talukdar et al.   ADVANCED FUNCTIONAL MATERIALS

Reconstruction of 3D stacked hepatocyte tissues using degradable, microporous poly(d,l-lactide-co-glycolide) membranes

(2012) Junichi Kasuya et al.   BIOMATERIALS

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids

(2012) Takahisa Anada et al.   BIOMATERIALS

Detailed interrogation of trypanosome cell biology via differential organelle staining and automated image analysis

(2012) Richard J Wheeler et al.   BMC BIOLOGY

Advances in the formation, use and understanding of multi-cellular spheroids

(2012) Toni-Marie Achilli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pannexin1 Drives Multicellular Aggregate Compaction via a Signaling Cascade That Remodels the Actin Cytoskeleton

(2012) Brian A. Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

(2012) Dmitry A. Markov et al.   LAB ON A CHIP

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

A 3D tumor spheroid chip with the pharmacokinetic drug elimination model developed by balanced droplet dispensing

(2012) Taeyoon Kim et al.   SENSORS AND ACTUATORS B-CHEMICAL

Microfluidic Encapsulation of Cells in Polymer Microgels

(2012) Diego Velasco et al.   Small

Recent developments in microfluidic devices for in vitro cell culture for cell-biology research

(2012) Dan Gao et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells

(2012) Wujie Zhang et al.   Journal of Materials Chemistry B

Molding Cell Beads for Rapid Construction of Macroscopic 3D Tissue Architecture

(2011) Yukiko T. Matsunaga et al.   ADVANCED MATERIALS

Thermoreversible Hydrogel for In Situ Generation and Release of HepG2 Spheroids

(2011) Dongdong Wang et al.   BIOMACROMOLECULES

The effect of static magnetic fields on the aggregation and cytotoxicity of magnetic nanoparticles

(2011) Ji-Eun Bae et al.   BIOMATERIALS

Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model

(2011) Sau Fung Wong et al.   BIOMATERIALS

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

Cell-enclosing gelatin-based microcapsule production for tissue engineering using a microfluidic flow-focusing system

(2011) Shinji Sakai et al.   Biomicrofluidics

Diffusion-mediated in situ alginate encapsulation of cell spheroids using microscale concave well and nanoporous membrane

(2011) Kwang Ho Lee et al.   LAB ON A CHIP

In vitro three-dimensional (3D) models in cancer research: An update

(2011) Lauren C. Kimlin et al.   MOLECULAR CARCINOGENESIS

Microencapsulation Technology: A Powerful Tool for Integrating Expansion and Cryopreservation of Human Embryonic Stem Cells

(2011) Margarida Serra et al.   PLoS One

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Chitosan composites with inorganics, morphogenetic proteins and stem cells, for bone regeneration

(2010) Riccardo A.A. Muzzarelli   CARBOHYDRATE POLYMERS

A multicellular spheroid formation and extraction chip using removable cell trapping barriers

(2010) Hye-Jin Jin et al.   LAB ON A CHIP

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

(2010) Heike Hardelauf et al.   LAB ON A CHIP

A Novel 3-D Mineralized Tumor Model to Study Breast Cancer Bone Metastasis

(2010) Siddharth P. Pathi et al.   PLoS One

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Engineering Tumors: A Tissue Engineering Perspective in Cancer Biology

(2010) Emily Burdett et al.   TISSUE ENGINEERING PART B-REVIEWS

Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells

(2009) Lisa A. Gurski et al.   BIOMATERIALS

Organ printing: Tissue spheroids as building blocks

(2009) Vladimir Mironov et al.   BIOMATERIALS

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

Monodisperse semi-permeable microcapsules for continuous observation of cells

(2009) Yuya Morimoto et al.   LAB ON A CHIP

Monodisperse Cell-Encapsulating Peptide Microgel Beads for 3D Cell Culture

(2009) Yukiko Tsuda et al.   LANGMUIR

Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles

(2009) Muri Han et al.   MOLECULAR THERAPY

Three-dimensional axisymmetric flow-focusing device using stereolithography

(2008) Yuya Morimoto et al.   BIOMEDICAL MICRODEVICES

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture

(2008) Yongjuan Chen et al.   DEVELOPMENTAL BIOLOGY

Fabrication of a modular tissue construct in a microfluidic chip

(2008) Derek A. Bruzewicz et al.   LAB ON A CHIP

Continuous generation of hydrogel beads and encapsulation of biological materials using a microfluidic droplet-merging channel

(2008) Eujin Um et al.   Microfluidics and Nanofluidics

Cell Encapsulation in Sub-mm Sized Gel Modules Using Replica Molding

(2008) Alison P. McGuigan et al.   PLoS One

Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs

(2008) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA