3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

(2018) Bu-Wei Huang et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance

(2018) Ji-Hyun Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Emerging tumor spheroids technologies for 3D in vitro cancer modeling

(2018) Tânia Rodrigues et al.   PHARMACOLOGY & THERAPEUTICS

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

(2018) Khashayar Moshksayan et al.   SENSORS AND ACTUATORS B-CHEMICAL

Development of an in vitro cell-sheet cancer model for chemotherapeutic screening

(2018) Jaewang Lee et al.   Theranostics

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells

(2017) André F. Moreira et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy

(2017) Ishna N. Mistry et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture

(2017) Cristina E. Rodríguez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Therapeutic Potential of Targeting Tumor Microenvironment in Breast Cancer: Rational Strategies and Recent Progress

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fabrication of micrometer-scale porous gelatin scaffolds for 3D cell culture

(2017) Kyuyoung Shim et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6

(2017) Robert S. Jones et al.   MOLECULAR PHARMACEUTICS

Cancer cell spheroids are a better screen for the photodynamic efficiency of glycosylated photosensitizers

(2017) Patrícia M. R. Pereira et al.   PLoS One

Cancer associated fibroblasts: An essential role in the tumor microenvironment

(2017) Leilei Tao et al.   Oncology Letters

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma

(2017) Shujing Liu et al.   Oncotarget

ROS and radiotherapy: more we care

(2017) Pierre Sonveaux   Oncotarget

Electrospinning PCL Scaffolds Manufacture for Three-Dimensional Breast Cancer Cell Culture

(2017) Marc Rabionet et al.   Polymers

Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation

(2017) Shaohua Wu et al.   Journal of Materials Chemistry B

Establishment of an orthotopic pancreatic cancer mouse model: Cells suspended and injected in Matrigel

(2017) Yong-Jian Jiang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D

(2017) Delyan P. Ivanov et al.   Scientific Reports

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

(2017) Daniel S. Reynolds et al.   Scientific Reports

Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo

(2017) Hong-Ryul Jung et al.   Scientific Reports

In vitro cancer cell–ECM interactions inform in vivo cancer treatment

(2016) Andrew W. Holle et al.   ADVANCED DRUG DELIVERY REVIEWS

Silk scaffolds connected with different naturally occurring biomaterials for prostate cancer cell cultivation in 3D

(2016) Anne Bäcker et al.   BIOPOLYMERS

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

In vitro models of cancer stem cells and clinical applications

(2016) Sara S. Franco et al.   BMC CANCER

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

(2016) Roger M. Phillips   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

(2016) Sylvia Herter et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

(2016) Alan McIntyre et al.   CANCER RESEARCH

Tumor spheroid assembly on hyaluronic acid-based structures: A review

(2016) Marco P. Carvalho et al.   CARBOHYDRATE POLYMERS

VEGF expression is regulated by HIF-1α and ARNT in 3D KYSE-70, esophageal cancer cell spheroids

(2016) Jun Terashima et al.   CELL BIOLOGY INTERNATIONAL

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Cell spheroids: the new frontiers in in vitro models for cancer drug validation

(2016) Maria Chatzinikolaidou   DRUG DISCOVERY TODAY

Liquid-based three-dimensional tumor models for cancer research and drug discovery

(2016) Stephanie L Ham et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Approaches for targeting cancer stem cells drug resistance

(2016) Roberta Rosa et al.   Expert Opinion on Drug Discovery

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review

(2016) André F. Moreira et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

(2016) Y. Qin et al.   MOLECULAR CANCER THERAPEUTICS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells

(2016) Kui Wang et al.   Advanced Healthcare Materials

Lead Phytochemicals for Anticancer Drug Development

(2016) Sukhdev Singh et al.   Frontiers in Plant Science

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Multidrug resistance characterization in multicellular tumour spheroids from two human lung cancer cell lines

(2015) Raúl Barrera-Rodríguez et al.   Cancer Cell International

Effects of Second and Subsequent Lines of Chemotherapy for Metastatic Breast Cancer

(2015) In Hae Park et al.   Clinical Breast Cancer

Cancer stem cells: a challenging paradigm for designing targeted drug therapies

(2015) Ishaq N. Khan et al.   DRUG DISCOVERY TODAY

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma

(2015) Chujie Bai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Engineering cancer microenvironments for in vitro 3-D tumor models

(2015) Waseem Asghar et al.   Materials Today

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics

(2015) A. Goodspeed et al.   MOLECULAR CANCER RESEARCH

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

In vitro human cell line models to predict clinical response to anticancer drugs

(2015) Nifang Niu et al.   PHARMACOGENOMICS

Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

(2015) Bhuvanalakshmi G et al.   PLoS One

E-cadherin increasing multidrug resistance protein 1 via hypoxia-inducible factor-1α contributes to multicellular resistance in colorectal cancer

(2015) Xi Liang et al.   TUMOR BIOLOGY

Alternatives to animal testing: A review

(2015) Sonali K. Doke et al.   SAUDI PHARMACEUTICAL JOURNAL

3D Porous Calcium-Alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy

(2015) Ching-Yun Chen et al.   Theranostics

Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment

(2015) Jian-Li Gao et al.   Biomed Research International

Epigenetic treatment of solid tumours: a review of clinical trials

(2015) Clara Nervi et al.   Clinical Epigenetics

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Abstract 3731: Luminescent cell health assays for tumor spheroid evaluation

(2015) Michael P. Valley et al.   CANCER RESEARCH

Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

(2015) Xue Gong et al.   PLoS One

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

(2015) Meher Majety et al.   PLoS One

Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models

(2014) Elisabete C. Costa et al.   BIOTECHNOLOGY AND BIOENGINEERING

Exploiting tumor cell senescence in anticancer therapy

(2014) Minyoung Lee et al.   BMB Reports

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

3D tumor models: history, advances and future perspectives

(2014) Parul Benien et al.   Future Oncology

Advances in 3D cell culture technologies enabling tissue-like structures to be createdin vitro

(2014) Eleanor Knight et al.   JOURNAL OF ANATOMY

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

(2014) D. R. Grimes et al.   Journal of the Royal Society Interface

Cilengitide Inhibits Attachment and Invasion of Malignant Pleural Mesothelioma Cells through Antagonism of Integrins αvβ3 and αvβ5

(2014) Ngan Ching Cheng et al.   PLoS One

Construction and characteristics of an E-cadherin-related three-dimensional suspension growth model of ovarian cancer

(2014) Shan Xu et al.   Scientific Reports

Oxygen consumption dynamics in steady-state tumour models

(2014) D. R. Grimes et al.   Royal Society Open Science

The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering

(2014) Jaspreet K Kular et al.   Journal of Tissue Engineering

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles

(2013) Xin Wang et al.   BIOMATERIALS

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

(2013) M Maftouh et al.   BRITISH JOURNAL OF CANCER

Altered energy metabolism in cancer

(2013) Yi Zhang et al.   CANCER BIOLOGY & THERAPY

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials

(2013) H. Fang et al.   CANCER RESEARCH

Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering

(2013) Tingli Lu et al.   International Journal of Nanomedicine

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Targeting cancer stem cells to suppress acquired chemotherapy resistance

(2013) S J Vidal et al.   ONCOGENE

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

(2013) Chandraiah Godugu et al.   PLoS One

Polyglycolic Acid–Polylactic Acid Scaffold Response to Different Progenitor Cell In Vitro Cultures: A Demonstrative and Comparative X-Ray Synchrotron Radiation Phase-Contrast Microtomography Study

(2013) Alessandra Giuliani et al.   TISSUE ENGINEERING PART C-METHODS

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

3D printed PLA-based scaffolds

(2013) Tiziano Serra et al.   Organogenesis

mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions

(2013) Shyuichiro Matsubara et al.   Scientific Reports

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Strategies to Increase Drug Penetration in Solid Tumors

(2013) Il-Kyu Choi et al.   Frontiers in Oncology

The Tumor Microenvironment and Strategies to Improve Drug Distribution

(2013) Jasdeep K. Saggar et al.   Frontiers in Oncology

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Anti-CD44 mAb remodels biological behaviors of spheroid cells with stemness from human ovarian cancer cell line SKOV-3

(2012) Chao Gu et al.   CHINESE SCIENCE BULLETIN

Targeting the Tumor Microenvironment for Cancer Therapy

(2012) N. E. Sounni et al.   CLINICAL CHEMISTRY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

(2012) Virginia Tirino et al.   FASEB JOURNAL

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Tumor stroma as targets for cancer therapy

(2012) Jing Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin

(2012) Pawel Swietach et al.   PLoS One

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

(2011) F. Meng et al.   MOLECULAR CANCER THERAPEUTICS

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

(2010) Tae-Hee Kim et al.   BIOMATERIALS

E-Cadherin Protects Primary Hepatocyte Spheroids from Cell Death by a Caspase-Independent Mechanism

(2010) Jennifer L. Luebke-Wheeler et al.   CELL TRANSPLANTATION

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Hypoxia-inducible factor-1α enhances the malignant phenotype of multicellular spheroid HeLa cells in vitro

(2010) XUN TIAN et al.   Oncology Letters

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

(2008) A Jeanes et al.   ONCOGENE