Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

Biochemical analysis on microfluidic chips

(2016) Jing Wu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Recent advances and future applications of microfluidic live-cell microarrays

(2015) Mario Rothbauer et al.   BIOTECHNOLOGY ADVANCES

Abstract B04: An in vitro model for glioblastoma using microfluidics: Generating pseudopalisades on a chip

(2015) Jose M. Ayuso et al.   CANCER RESEARCH

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

(2015) Abigail Hielscher et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroC3: an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells

(2015) Chorom Pak et al.   Integrative Biology

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Towards personalized medicine: chemosensitivity assays of patient lung cancer cell spheroids in a perfused microfluidic platform

(2015) Janine Ruppen et al.   LAB ON A CHIP

Microfluidic devices to enrich and isolate circulating tumor cells

(2015) J. H. Myung et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models

(2015) Mariana R. Carvalho et al.   TRENDS IN BIOTECHNOLOGY

A bladder cancer microenvironment simulation system based on a microfluidic co-culture model

(2015) Peng-fei Liu et al.   Oncotarget

Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment

(2015) Yang Zhao et al.   Oncotarget

SU-8 Based Microdevices to Study Self-Induced Chemotaxis in 3D Microenvironments

(2015) Jose Maria Ayuso et al.   Frontiers in Materials

Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform

(2015) Li Ying et al.   PLoS One

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model

(2015) Zhuo Zhang et al.   Oncotarget

Microfluidics-Based in Vivo Mimetic Systems for the Study of Cellular Biology

(2014) Donghyuk Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

(2014) Zeynep Dereli-Korkut et al.   ANALYTICAL CHEMISTRY

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biomimetic Tissue-Engineered Systems for Advancing Cancer Research: NCI Strategic Workshop Report

(2014) T. K. Schuessler et al.   CANCER RESEARCH

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip

(2014) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

Rare cell isolation and analysis in microfluidics

(2014) Yuchao Chen et al.   LAB ON A CHIP

Parallel microfluidic chemosensitivity testing on individual slice cultures

(2014) Tim C. Chang et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development

(2014) Jason E. Ekert et al.   PLoS One

Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells

(2014) Bee Luan Khoo et al.   PLoS One

Methods to study the tumor microenvironment under controlled oxygen conditions

(2014) Matthew B. Byrne et al.   TRENDS IN BIOTECHNOLOGY

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

On-chip investigation of cell–drug interactions

(2013) Xin Ting Zheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

(2013) Nam-Trung Nguyen et al.   ADVANCED DRUG DELIVERY REVIEWS

Cardiohepatic interactions in heart failure

(2013) Mehmet Birhan Yilmaz et al.   Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology

A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing

(2013) Derek Yip et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Microfluidics and cancer: are we there yet?

(2013) Zhuo Zhang et al.   BIOMEDICAL MICRODEVICES

A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based enzyme-linked immunosorbent assay

(2013) Yen-Heng Lin et al.   Biomicrofluidics

Highly sensitive enumeration of circulating tumor cells in lung cancer patients using a size-based filtration microfluidic chip

(2013) Ting Huang et al.   BIOSENSORS & BIOELECTRONICS

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Cardiohepatic Interactions in Heart Failure

(2013) Marc D. Samsky et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Rapid translation of circulating tumor cell biomarkers into clinical practice: technology development, clinical needs and regulatory requirements

(2013) Jonathan D. King et al.   LAB ON A CHIP

A microfluidic system to study the cytotoxic effect of drugs: the combined effect of celecoxib and 5-fluorouracil on normal and cancer cells

(2013) Elzbieta Jastrzebska et al.   MICROCHIMICA ACTA

Engineering microfluidic concentration gradient generators for biological applications

(2013) Alicia G. G. Toh et al.   Microfluidics and Nanofluidics

Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets

(2013) Hyeun Joong Yoon et al.   Nature Nanotechnology

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system

(2013) Q. An et al.   NEURO-ONCOLOGY

Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device

(2013) Shanshan Wang et al.   PLoS One

Functional Investigation of NCI-H460-Inducible Myofibroblasts on the Chemoresistance to VP-16 with a Microfluidic 3D Co-Culture Device

(2013) Yuanyuan Hao et al.   PLoS One

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Isolation and retrieval of circulating tumor cells using centrifugal forces

(2013) Han Wei Hou et al.   Scientific Reports

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids

(2012) Takahisa Anada et al.   BIOMATERIALS

Three dimensional multicellular co-cultures and anti-cancer drug assays in rapid prototyped multilevel microfluidic devices

(2012) Hyundoo Hwang et al.   BIOMEDICAL MICRODEVICES

Immunomagnetic nanoscreening of circulating tumor cells with a motion controlled microfluidic system

(2012) Yu-yen Huang et al.   BIOMEDICAL MICRODEVICES

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Microscale functional cytomics for studying hematologic cancers

(2012) E. W. K. Young et al.   BLOOD

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

Microtube Device for Selectin-Mediated Capture of Viable Circulating Tumor Cells from Blood

(2012) A. D. Hughes et al.   CLINICAL CHEMISTRY

A multilayer microdevice for cell-based high-throughput drug screening

(2012) Chong Liu et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

SERS-based immunoassay using a gold array-embedded gradient microfluidic chip

(2012) Moonkwon Lee et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

On-chip anticancer drug test of regular tumor spheroids formed in microwells by a distributive microchannel network

(2012) Choong Kim et al.   LAB ON A CHIP

Eccentricity Effect of Micropatterned Surface on Contact Angle

(2012) Navid Kashaninejad et al.   LANGMUIR

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Eccentricity effects of microhole arrays on drag reduction efficiency of microchannels with a hydrophobic wall

(2012) Navid Kashaninejad et al.   PHYSICS OF FLUIDS

Rapid and Sensitive MicroRNA Detection with Laminar Flow-Assisted Dendritic Amplification on Power-Free Microfluidic Chip

(2012) Hideyuki Arata et al.   PLoS One

The three-phase contact line shape and eccentricity effect of anisotropic wetting on hydrophobic surfaces

(2012) Navid Kashaninejad et al.   Soft Matter

Micro Total Analysis Systems for Cell Biology and Biochemical Assays

(2011) Michelle L. Kovarik et al.   ANALYTICAL CHEMISTRY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

(2011) Maren Drewitz et al.   Biotechnology Journal

piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells

(2011) Jia Cheng et al.   CLINICA CHIMICA ACTA

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   LAB ON A CHIP

Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature

(2011) Alireza Salmanzadeh et al.   LAB ON A CHIP

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

(2011) Yu Huang et al.   Jove-Journal of Visualized Experiments

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Chemotherapy resistance research of lung cancer based on micro-fluidic chip system with flow medium

(2010) Long Zhao et al.   BIOMEDICAL MICRODEVICES

Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients

(2010) Swee Jin Tan et al.   BIOSENSORS & BIOELECTRONICS

Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer

(2010) L M Flores et al.   BRITISH JOURNAL OF CANCER

A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens

(2010) J. Sun et al.   CANCER RESEARCH

Tumors on chips: oncology meets microfluidics

(2010) Donald Wlodkowic et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device

(2010) Huipeng Ma et al.   ELECTROPHORESIS

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

The CTC-Chip: An Exciting New Tool to Detect Circulating Tumor Cells in Lung Cancer Patients

(2010) Lecia V. Sequist et al.   Journal of Thoracic Oncology

Expression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer

(2010) Xiao-Chun Wang et al.   LUNG CANCER

Assay of glioma cell responses to an anticancer drug in a cell-based microfluidic device

(2010) Wenming Liu et al.   Microfluidics and Nanofluidics

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

(2010) S. L. Stott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Enrichment of Cancer Cells Using Aptamers Immobilized on a Microfluidic Channel

(2009) Joseph A. Phillips et al.   ANALYTICAL CHEMISTRY

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients

(2009) T. K.F. Yung et al.   CLINICAL CANCER RESEARCH

Circulating Tumor Cell as a Diagnostic Marker in Primary Lung Cancer

(2009) F. Tanaka et al.   CLINICAL CANCER RESEARCH

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance

(2008) Wang Siyan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-Free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor

(2008) André A. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

(2008) Vernella Vickerman et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Detection of Mutations inEGFRin Circulating Lung-Cancer Cells

(2008) Shyamala Maheswaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS