Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models

Generation of multicellular tumor spheroids of breast cancer cells: How to go three-dimensional

(2013) Anika Nagelkerke et al.   ANALYTICAL BIOCHEMISTRY

Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel

(2013) Xinyi Jiang et al.   BIOMATERIALS

Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

(2013) M.P. Ribeiro et al.   Materials Science & Engineering C-Materials for Biological Applications

A better brew

(2013) Vivien Marx   NATURE

Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

(2013) Andrew S. Mikhail et al.   PLoS One

Application of Concave Microwells to Pancreatic Tumor Spheroids Enabling Anticancer Drug Evaluation in a Clinically Relevant Drug Resistance Model

(2013) Sang-Eun Yeon et al.   PLoS One

Evaluation of Nanoparticle Uptake in Co-culture Cancer Models

(2013) Elisabete C. Costa et al.   PLoS One

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

The Tumor Microenvironment Contribution to Development, Growth, Invasion and Metastasis of Head and Neck Squamous Cell Carcinomas

(2013) Sittichai Koontongkaew   Journal of Cancer

Cellular Heterogeneity and Molecular Evolution in Cancer

(2012) Vanessa Almendro et al.   Annual Review of Pathology-Mechanisms of Disease

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

(2012) Ying-Hui Ko et al.   CANCER BIOLOGY & THERAPY

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Anti-angiogenesis therapy in cancer: Current challenges and future perspectives

(2012) Farbod Shojaei   CANCER LETTERS

Three-dimensional tissue cultures: current trends and beyond

(2012) Henry Page et al.   CELL AND TISSUE RESEARCH

Synthetic 3D multicellular systems for drug development

(2012) Markus Rimann et al.   CURRENT OPINION IN BIOTECHNOLOGY

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

(2012) Chan Yeom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

The advantages of co-culture over mono cell culture in simulating in vivo environment

(2012) Yasuhiro Miki et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

The liquid overlay technique is the key to formation of co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells

(2011) Wolfgang Metzger et al.   CYTOTHERAPY

Role of cancer-associated fibroblasts in breast cancer development and prognosis

(2011) Abdelilah Aboussekhra   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy

(2011) Vítor M. Gaspar et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Drug Delivery and Penetration Into Solid Tumors

(2011) Angelo Corti et al.   MEDICINAL RESEARCH REVIEWS

Ethical and Scientific Considerations Regarding Animal Testing and Research

(2011) Hope R. Ferdowsian et al.   PLoS One

MCF-7 Cells as a Three-Dimensional Model for the Study of Human Breast Cancer

(2011) Jônatas Bussador do Amaral et al.   TISSUE ENGINEERING PART C-METHODS

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Histological types of breast cancer: How special are they?

(2010) Britta Weigelt et al.   Molecular Oncology

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Garlic Accelerates Red Blood Cell Turnover and Splenic Erythropoietic Gene Expression in Mice: Evidence for Erythropoietin-Independent Erythropoiesis

(2010) Bünyamin Akgül et al.   PLoS One

Tumour-microenvironmental interactions: paths to progression and targets for treatment

(2010) Carol Box et al.   SEMINARS IN CANCER BIOLOGY

Engineering Tumors: A Tissue Engineering Perspective in Cancer Biology

(2010) Emily Burdett et al.   TISSUE ENGINEERING PART B-REVIEWS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY

In vitro biocompatibility of three-dimensional chitosan scaffolds immobilized with chondroitin-6-sulfate

(2007) Chi-Hsiung Jou et al.   POLYMERS FOR ADVANCED TECHNOLOGIES