Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor cell intravasation

(2016) Serena P. H. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Microfluidics for research and applications in oncology

(2016) Parthiv Kant Chaudhuri et al.   ANALYST

Microfluidics and cancer analysis: cell separation, cell/tissue culture, cell mechanics, and integrated analysis systems

(2016) Dimitri Pappas   ANALYST

Microfluidics for cell-based high throughput screening platforms—A review

(2016) Guansheng Du et al.   ANALYTICA CHIMICA ACTA

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

Screening applications in drug discovery based on microfluidic technology

(2016) P. Eribol et al.   Biomicrofluidics

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Have microfluidics delivered for drug discovery?

(2016) Arvind Chandrasekaran et al.   Expert Opinion on Drug Discovery

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

(2016) Alexandra S. Piotrowski-Daspit et al.   Integrative Biology

Tumour angiogenesis-Origin of blood vessels

(2016) S. Krishna Priya et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanobiology of cell migration in the context of dynamic two-way cell–matrix interactions

(2016) Nicholas A. Kurniawan et al.   JOURNAL OF BIOMECHANICS

Gene of the month:HGF

(2016) Ana Belen Fajardo-Puerta et al.   JOURNAL OF CLINICAL PATHOLOGY

Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives

(2016) Michael B. Atkins et al.   JNCI-Journal of the National Cancer Institute

A micro-perfusion bioreactor for on line investigation of ECM remodeling under hydrodynamic and biochemical stimulation

(2016) A. Garziano et al.   LAB ON A CHIP

Digital microfluidics for spheroid-based invasion assays

(2016) Brian F. Bender et al.   LAB ON A CHIP

A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis

(2016) A. Spencer et al.   LAB ON A CHIP

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

(2016) Bruce A. Corliss et al.   MICROCIRCULATION

Vinculin regulates directionality and cell polarity in two- and three-dimensional matrix and three-dimensional microtrack migration

(2016) Aniqua Rahman et al.   MOLECULAR BIOLOGY OF THE CELL

Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery

(2016) Mehmet Fatih Bolukbasi et al.   NATURE METHODS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

(2016) Ting Yu et al.   Oncotarget

Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives

(2016) Michael B. Atkins et al.   JNCI-Journal of the National Cancer Institute

Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis

(2016) Susan Hua et al.   Frontiers in Pharmacology

Spontaneous regression in advanced squamous cell lung carcinoma

(2016) Yeon Hee Park et al.   Journal of Thoracic Disease

High Throughput Label Free Measurement of Cancer Cell Adhesion Kinetics Under Hemodynamic Flow

(2016) Adrianne Spencer et al.   Scientific Reports

Quantitative Study of Cell Invasion Process under Extracellular Stimulation of Cytokine in a Microfluidic Device

(2016) Kin Fong Lei et al.   Scientific Reports

Microfluidic Multiculture Assay to Analyze Biomolecular Signaling in Angiogenesis

(2015) Ashleigh B. Theberge et al.   ANALYTICAL CHEMISTRY

Cancer stem cells: a potential target for cancer therapy

(2015) Hong Qiu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spontaneous regression of primary renal cell carcinoma following image-guided percutaneous biopsy

(2015) Elliot C. Dickerson et al.   CLINICAL IMAGING

Utilizing a high-throughput microfluidic platform to study hypoxia-driven mesenchymal-mode cell migration

(2015) Yuanqing Zhang et al.   Integrative Biology

An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

(2015) M. Pisano et al.   Integrative Biology

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamics of Interstitial Fluid Pressure in Extracellular Matrix Hydrogels in Microfluidic Devices

(2015) Joe Tien et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Generation of stable orthogonal gradients of chemical concentration and substrate stiffness in a microfluidic device

(2015) S. García et al.   LAB ON A CHIP

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

(2015) Choong Kim et al.   LAB ON A CHIP

An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells

(2015) Xue-Ying Wang et al.   LAB ON A CHIP

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Engineering cancer microenvironments for in vitro 3-D tumor models

(2015) Waseem Asghar et al.   Materials Today

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments

(2015) Majid Malboubi et al.   MICROELECTRONIC ENGINEERING

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Microfluidics: reframing biological enquiry

(2015) Todd A. Duncombe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beyond 3D culture models of cancer

(2015) Kandice Tanner et al.   Science Translational Medicine

Investigation of Tumor Cell Behaviors on a Vascular Microenvironment-Mimicking Microfluidic Chip

(2015) Rong Huang et al.   Scientific Reports

Microfluidic cytometric analysis of cancer cell transportability and invasiveness

(2015) Zongbin Liu et al.   Scientific Reports

Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations

(2015) Yu-Chih Chen et al.   Scientific Reports

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion

(2015) Hideki Yamaguchi et al.   Cancers

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Epithelial to Mesenchymal Transition in a Clinical Perspective

(2015) Jennifer Pasquier et al.   Journal of Oncology

Metastasis: Other Side of the Coin

(2015) Aftab Ahmad et al.   Frontiers in Oncology

Enrichment of the Cancer Stem Phenotype in Sphere Cultures of Prostate Cancer Cell Lines Occurs through Activation of Developmental Pathways Mediated by the Transcriptional Regulator ΔNp63α

(2015) Roberto Portillo-Lara et al.   PLoS One

Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement

(2014) Anna Haeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

(2014) Hyunjae Lee et al.   Biomicrofluidics

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

(2014) Miguel A. Acosta et al.   Biomicrofluidics

3D Traction Stresses Activate Protease-Dependent Invasion of Cancer Cells

(2014) Aereas Aung et al.   BIOPHYSICAL JOURNAL

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis

(2014) H.-Y. Jung et al.   CLINICAL CANCER RESEARCH

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells

(2014) Lauren L. Bischel et al.   Integrative Biology

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Spontaneous remission of a squamous cell carcinoma of the floor of the mouth

(2014) Alexandre de Andrade Sousa et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

A cancer model for the angiogenic switch

(2014) Louise Viger et al.   JOURNAL OF THEORETICAL BIOLOGY

Research highlights: microtechnologies for engineering the cellular environment

(2014) Peter Tseng et al.   LAB ON A CHIP

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-6 feed-forward loop: A driver of tumorigenesis

(2014) Qing Chang et al.   SEMINARS IN IMMUNOLOGY

Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer

(2014) Mousumi Tania et al.   TUMOR BIOLOGY

Animal models and therapeutic molecular targets of cancer: utility and limitations

(2014) Maria Cekanova et al.   Drug Design Development and Therapy

Evolving concepts of tumor heterogeneity

(2014) Victoria R Zellmer et al.   Cell and Bioscience

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Animal models of disease: Pre-clinical animal models of cancer and their applications and utility in drug discovery

(2013) Bruce A. Ruggeri et al.   BIOCHEMICAL PHARMACOLOGY

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

Three-Dimensional Scaffolds to Evaluate Tumor Associated Fibroblast-Mediated Suppression of Breast Tumor Specific T Cells

(2013) Vy Phan-Lai et al.   BIOMACROMOLECULES

Biomimetic tumor microenvironment on a microfluidic platform

(2013) Huipeng Ma et al.   Biomicrofluidics

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Tumour suppressor gene function in carcinoma-associated fibroblasts: from tumour cells via EMT and back again?

(2013) Lauren E Drake et al.   JOURNAL OF PATHOLOGY

Advances of lab-on-a-chip in isolation, detection and post-processing of circulating tumour cells

(2013) Ling Yu et al.   LAB ON A CHIP

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Disease-on-a-chip: mimicry of tumor growth in mammary ducts

(2013) Pierre-Alexandre Vidi et al.   LAB ON A CHIP

Apoptotic Circulating Tumor Cells in Early and Metastatic Breast Cancer Patients

(2013) G. Kallergi et al.   MOLECULAR CANCER THERAPEUTICS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway?

(2013) Hassan Fazilaty et al.   TUMOR BIOLOGY

Organotypic systems in drug metabolism and toxicity: challenges and opportunities

(2012) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Microfluidic approaches for cancer cell detection, characterization, and separation

(2012) Jian Chen et al.   LAB ON A CHIP

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair

(2012) Oliver Zschenker et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

(2010) Jan Brábek et al.   Cell Communication and Signaling

A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix

(2009) Tingjiao Liu et al.   ELECTROPHORESIS

Tumor metastasis and the lymphatic vasculature

(2009) Jonathan P. Sleeman et al.   INTERNATIONAL JOURNAL OF CANCER

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics

(2008) Colin L. Walsh et al.   LAB ON A CHIP

Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids

(2008) Hari R. Kumar et al.   PEDIATRIC SURGERY INTERNATIONAL