A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

Fluid shear stress activates YAP1 to promote cancer cell motility

(2017) Hyun Jung Lee et al.   Nature Communications

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment

(2016) Daniel Delitto et al.   CANCER RESEARCH

Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer

(2016) Yuan Tang et al.   Clinical Breast Cancer

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil–endothelium interaction

(2016) Fariborz Soroush et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip

(2016) Kyeonggon Shin et al.   MOLECULAR PHARMACEUTICS

An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

(2015) M. Pisano et al.   Integrative Biology

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Synthetic tumor networks for screening drug delivery systems

(2015) Balabhaskar Prabhakarpandian et al.   JOURNAL OF CONTROLLED RELEASE

An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells

(2015) Xue-Ying Wang et al.   LAB ON A CHIP

Investigation of Tumor Cell Behaviors on a Vascular Microenvironment-Mimicking Microfluidic Chip

(2015) Rong Huang et al.   Scientific Reports

Tumor cell secretion of soluble factor(s) for specific immunosuppression

(2015) Arihiro Kano   Scientific Reports

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions

(2014) Giuseppina Lamberti et al.   ANALYTICAL CHEMISTRY

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

(2014) Hyunjae Lee et al.   Biomicrofluidics

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip

(2014) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model

(2014) Yuan Tang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanisms Regulating Endothelial Permeability

(2014) Sukriti Sukriti et al.   Pulmonary Circulation

Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology

(2014) Sihem Ait-Oudhia et al.   Pharmaceutics

Humanizing the Mouse: In Defense of Murine Models of Critical Illness

(2013) Harris Perlman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tight junction proteins: From barrier to tumorigenesis

(2013) E. Aaron Runkle et al.   CANCER LETTERS

Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration

(2013) Kwang Ho Lee et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

(2013) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Current trends in the use of liposomes for tumor targeting

(2013) Pranali P Deshpande et al.   Nanomedicine

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

(2013) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress

(2013) Michael J. Mitchell et al.   Frontiers in Oncology

Microfluidic Models of Vascular Functions

(2012) Keith H.K. Wong et al.   Annual Review of Biomedical Engineering

Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

(2012) Hiroshi Maeda   JOURNAL OF CONTROLLED RELEASE

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How can grafted breast cancer models be optimized?

(2011) Séverine Mollard et al.   CANCER BIOLOGY & THERAPY

Cancer Cells Regulate Biomechanical Properties of Human Microvascular Endothelial Cells

(2011) Claudia Tanja Mierke   JOURNAL OF BIOLOGICAL CHEMISTRY

Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature

(2011) Balabhaskar Prabhakarpandian et al.   MICROVASCULAR RESEARCH

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

(2010) Walid S Kamoun et al.   NATURE METHODS

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Radiation-Guided Targeting of Combretastatin Encapsulated Immunoliposomes to Mammary Tumors

(2009) Christopher B. Pattillo et al.   PHARMACEUTICAL RESEARCH

Synthetic microvascular networks for quantitative analysis of particle adhesion

(2008) Balabhaskar Prabhakarpandian et al.   BIOMEDICAL MICRODEVICES

Breakdown of the Endothelial Barrier Function in Tumor Cell Transmigration

(2007) Claudia Tanja Mierke et al.   BIOPHYSICAL JOURNAL