Organ-on-a-Chip for Cancer and Immune Organs Modeling

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Response

(2018) Bartłomiej Wysocki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure and physico-mechanical properties of low temperature plasma treated electrospun nanofibrous scaffolds examined with atomic force microscopy

(2018) Adrian Chlanda et al.   MICRON

Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy

(2018) Yimin Wang et al.   NANOTECHNOLOGY

Optimized base editors enable efficient editing in cells, organoids and mice

(2018) Maria Paz Zafra et al.   NATURE BIOTECHNOLOGY

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Concerns, challenges and promises of high-content analysis of 3D cellular models

(2018) Neil Carragher et al.   NATURE REVIEWS DRUG DISCOVERY

Therapy: Arming the regulators — new strategies to treat autoimmunity

(2018) Richard O. Williams et al.   Nature Reviews Rheumatology

In the bank: bladder organoids recapitulate original tumour

(2018) Louise Stone   Nature Reviews Urology

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

(2018) Jon N. Buzzelli et al.   Stem Cell Research

Patient derived organoids to model rare prostate cancer phenotypes

(2018) Loredana Puca et al.   Nature Communications

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

Biofabrication strategies for 3D in vitro models and regenerative medicine

(2018) Lorenzo Moroni et al.   Nature Reviews Materials

A review of microfluidic approaches for investigating cancer extravasation during metastasis

(2018) Yu-Heng Vivian Ma et al.   Microsystems & Nanoengineering

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

(2018) Yongzhi Qiu et al.   Nature Biomedical Engineering

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

(2018) Teng Su et al.   ACS Applied Materials & Interfaces

Applications of tumor chip technology

(2018) Stephanie J. Hachey et al.   LAB ON A CHIP

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

CAR-T's forge ahead, despite Juno deaths

(2017) Laura DeFrancesco   NATURE BIOTECHNOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

(2017) Myrthe Jager et al.   Nature Protocols

Immunotherapy: Tisagenlecleucel — the first approved CAR-T-cell therapy: implications for payers and policy makers

(2017) Vinay Prasad   Nature Reviews Clinical Oncology

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal cues regulate the pancreatic cancer epigenome and metabolome

(2017) Mara H. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human tissues in a dish: The research and ethical implications of organoid technology

(2017) Annelien L. Bredenoord et al.   SCIENCE

Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair

(2017) René R. Sevag Packard et al.   Scientific Reports

Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

(2017) Byung-Hyun Cha et al.   Advanced Healthcare Materials

Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval

(2017) Vinay Prasad et al.   JAMA Internal Medicine

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials-Science & Engineering

Biophysical regulation of cell reprogramming

(2017) Sze Yue Wong et al.   Current Opinion in Chemical Engineering

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials Science & Engineering

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs

(2017) Fabián Salazar et al.   Scientific Reports

Stem cell-based therapies for HIV/AIDS

(2016) Olivier Pernet et al.   ADVANCED DRUG DELIVERY REVIEWS

A three dimensional micropatterned tumor model for breast cancer cell migration studies

(2016) Nitish Peela et al.   BIOMATERIALS

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014

(2016) Nadine Shehab et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production

(2016) Alberto Purwada et al.   Nature Protocols

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Ex vivo engineered immune organoids for controlled germinal center reactions

(2015) Alberto Purwada et al.   BIOMATERIALS

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Electrochemistry, biosensors and microfluidics: a convergence of fields

(2015) Darius G. Rackus et al.   CHEMICAL SOCIETY REVIEWS

Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease

(2015) Brian H. Bird et al.   JOURNAL OF INFECTIOUS DISEASES

Infection and immunity on a chip: a compartmentalised microfluidic platform to monitor immune cell behaviour in real time

(2015) N. Gopalakrishnan et al.   LAB ON A CHIP

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts

(2015) Yong Fan et al.   MOLECULAR THERAPY

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Toward recreating colon cancer in human organoids

(2015) Ameen A Salahudeen et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing

(2015) Burak Dura et al.   Nature Communications

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

(2015) Biswanath Majumder et al.   Nature Communications

Integrin-Mediated Interactions between B Cells and Follicular Dendritic Cells Influence Germinal Center B Cell Fitness

(2014) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Bioinspired structural materials

(2014) Ulrike G. K. Wegst et al.   NATURE MATERIALS

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Three-dimensional printing of Hela cells for cervical tumor modelin vitro

(2014) Yu Zhao et al.   Biofabrication

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

(2013) Robert P. Fordham et al.   Cell Stem Cell

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion

(2012) Sung Kyu Kim et al.   ANALYST

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

(2012) Amir R. Aref et al.   Integrative Biology

An Organotypic Coculture Model Supporting Proliferation and Differentiation of Medullary Thymic Epithelial Cells and Promiscuous Gene Expression

(2012) S. Pinto et al.   JOURNAL OF IMMUNOLOGY

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

(2012) C. N. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

(2011) U. Haessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Notch Ligand Presenting Acellular 3D Microenvironments for ex vivo Human Hematopoietic Stem-Cell Culture made by Layer-By-Layer Assembly

(2009) Jungwoo Lee et al.   Small

In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry

(2008) Joan E. Nichols et al.   BIOMATERIALS

Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration

(2007) Agnieszka N. Stachowiak et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity

(2007) Darrell J. Irvine et al.   SEMINARS IN IMMUNOLOGY