In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

(2016) Bumsoo Han et al.   CANCER LETTERS

A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil–endothelium interaction

(2016) Fariborz Soroush et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Uptake of silver nanoparticles by monocytic THP-1 cells depends on particle size and presence of serum proteins

(2016) Katja Kettler et al.   JOURNAL OF NANOPARTICLE RESEARCH

Real-time assessment of nanoparticle-mediated antigen delivery and cell response

(2016) Carlota A. Cunha-Matos et al.   LAB ON A CHIP

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy-Problems, Solutions, and Prospects

(2016) Hiroshi Maeda et al.   MICROCIRCULATION

Why I’m Holding onto Hope for Nano in Oncology

(2016) Christine Allen   MOLECULAR PHARMACEUTICS

Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip

(2016) Kyeonggon Shin et al.   MOLECULAR PHARMACEUTICS

High-throughput single cell multidrug resistance analysis with multifunctional gradients-customizing microfluidic device

(2016) Yiwei Li et al.   SENSORS AND ACTUATORS B-CHEMICAL

Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform

(2016) Ioannis K. Zervantonakis et al.   Small

Current understanding of interactions between nanoparticles and the immune system

(2016) Marina A. Dobrovolskaia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer

(2016) Eri Yoshida et al.   Oncology Letters

Application of a microfluidic-based perivascular tumor model for testing drug sensitivity in head and neck cancers and toxicity in endothelium

(2016) Dong Jin et al.   RSC Advances

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System

(2016) Nicholas Edwin Clay et al.   ACS Biomaterials-Science & Engineering

Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System

(2016) Nicholas Edwin Clay et al.   ACS Biomaterials Science & Engineering

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform

(2015) Wenming Liu et al.   ANALYTICAL CHEMISTRY

A multilayered microfluidic blood vessel-like structure

(2015) Anwarul Hasan et al.   BIOMEDICAL MICRODEVICES

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure

(2015) Lauren L Bischel et al.   BMC CANCER

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

(2015) A. F. Bagley et al.   CANCER RESEARCH

Microfabrication of polydimethylsiloxane phantoms to simulate tumor hypoxia and vascular anomaly

(2015) Qiang Wu et al.   JOURNAL OF BIOMEDICAL OPTICS

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier

(2015) Kenji Yokoi et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic tumor networks for screening drug delivery systems

(2015) Balabhaskar Prabhakarpandian et al.   JOURNAL OF CONTROLLED RELEASE

Towards personalized medicine: chemosensitivity assays of patient lung cancer cell spheroids in a perfused microfluidic platform

(2015) Janine Ruppen et al.   LAB ON A CHIP

Investigation into the hypoxia-dependent cytotoxicity of anticancer drugs under oxygen gradient in a microfluidic device

(2015) Zonghua Wang et al.   Microfluidics and Nanofluidics

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Designing a Microfluidic Device with Integrated Ratiometric Oxygen Sensors for the Long-Term Control and Monitoring of Chronic and Cyclic Hypoxia

(2015) Samantha Grist et al.   SENSORS

Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform

(2015) Sebastien G. M. Uzel et al.   Small

HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases

(2015) Haruhiko Dozono et al.   Targeted Oncology

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment

(2015) Jing Bai et al.   Oncotarget

Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models

(2015) Rachit Agarwal et al.   Advanced Healthcare Materials

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

A microfluidic digital single-cell assay for the evaluation of anticancer drugs

(2014) Yao Wang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

(2014) Dami An et al.   Biomolecules & Therapeutics

Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip

(2014) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

(2014) Janine Ruppen et al.   LAB ON A CHIP

A polydimethylsiloxane–polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies

(2014) Chia-Wen Chang et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

A collagen-based multicellular tumor spheroid model for evaluation of the efficiency of nanoparticle drug delivery

(2014) Van-Minh Le et al.   Artificial Cells Nanomedicine and Biotechnology

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Facing the Truth about Nanotechnology in Drug Delivery

(2013) Kinam Park   ACS Nano

Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System

(2013) Guan-Sheng Du et al.   ANALYTICAL CHEMISTRY

Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

(2013) Gang Bao et al.   Annual Review of Biomedical Engineering

Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics

(2013) Ching-Te Kuo et al.   BIOMATERIALS

Empirical chemosensitivity testing in a spheroid model of ovarian cancer using a microfluidics-based multiplex platform

(2013) Tamal Das et al.   Biomicrofluidics

Microfluidic chip integrated with flexible PDMS-based electrochemical cytosensor for dynamic analysis of drug-induced apoptosis on HeLa cells

(2013) Jun-Tao Cao et al.   BIOSENSORS & BIOELECTRONICS

Real-time and non-invasive impedimetric monitoring of cell proliferation and chemosensitivity in a perfusion 3D cell culture microfluidic chip

(2013) Kin Fong Lei et al.   BIOSENSORS & BIOELECTRONICS

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil

(2013) Bhushan J. Toley et al.   Integrative Biology

The internalization of fluorescence-labeled PLA nanoparticles by macrophages

(2013) Fengjuan Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice

(2013) Darren Lars Stirland et al.   JOURNAL OF CONTROLLED RELEASE

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

(2013) Andreas Weltin et al.   LAB ON A CHIP

Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug

(2013) Crystal S. Shin et al.   MOLECULAR PHARMACEUTICS

Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment

(2013) Altug Ozcelikkale et al.   MOLECULAR PHARMACEUTICS

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

(2013) P. Kolhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

(2012) Emanuel Fleige et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer nanomedicines: So many papers and so few drugs!

(2012) Vincent J. Venditto et al.   ADVANCED DRUG DELIVERY REVIEWS

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

The preferential targeting of the diseased microvasculature by disk-like particles

(2012) Giulia Adriani et al.   BIOMATERIALS

Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics

(2012) Ivan Rios-Mondragon et al.   Biomicrofluidics

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Analysis on the current status of targeted drug delivery to tumors

(2012) Il Keun Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

(2012) Rong Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Full range physiological mass transport control in 3D tissue cultures

(2012) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Guided delivery of polymer therapeutics using plasmonic photothermal therapy

(2012) Adam J. Gormley et al.   Nano Today

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

(2012) Xiaopin Duan et al.   Small

Tumor Accumulation of NIR Fluorescent PEG–PLA Nanoparticles: Impact of Particle Size and Human Xenograft Tumor Model

(2011) Andreas Schädlich et al.   ACS Nano

Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution

(2011) Sandrine Dufort et al.   ADVANCED DRUG DELIVERY REVIEWS

The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles

(2011) Margriet V.D.Z. Park et al.   BIOMATERIALS

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

(2011) Qianjun He et al.   BIOMATERIALS

Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells

(2011) Ekaterina Y. Lukianova-Hleb et al.   BIOMATERIALS

A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors

(2011) Nelita T. Elliott et al.   BIOTECHNOLOGY AND BIOENGINEERING

Size dependent macrophage responses and toxicological effects of Ag nanoparticles

(2011) Jeongsin Park et al.   CHEMICAL COMMUNICATIONS

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

(2011) Xiao-Dong Zhang et al.   International Journal of Nanomedicine

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Intratumoral Drug Delivery with Nanoparticulate Carriers

(2011) Hillary Holback et al.   PHARMACEUTICAL RESEARCH

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines

(2011) Tiago dos Santos et al.   Small

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands

(2010) Xiaohua Huang et al.   ACS Nano

Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects

(2010) Kazuo Maruyama   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice

(2010) Tianlong Liu et al.   BIOMATERIALS

Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation

(2010) Triantafyllos Stylianopoulos et al.   BIOPHYSICAL JOURNAL

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Stimuli-responsive magnetic particles for biomedical applications

(2010) S.F. Medeiros et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles

(2010) Helen Lee et al.   MOLECULAR PHARMACEUTICS

The rise and rise of stealth nanocarriers for cancer therapy: passive versus active targeting

(2010) Ngoc Trinh Huynh et al.   Nanomedicine

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo Distribution of Polymeric Nanoparticles at the Whole-Body, Tumor, and Cellular Levels

(2010) Helen Lee et al.   PHARMACEUTICAL RESEARCH

Polymer particles that switch shape in response to a stimulus

(2010) J.-W. Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass

(2009) Oliver Lieleg et al.   BIOPHYSICAL JOURNAL

Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles

(2009) Xiang Rong Song et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Silica nanoparticles as hepatotoxicants

(2009) Hikaru Nishimori et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells

(2009) Ka Yaw Teo et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance

(2009) Yogesh Patil et al.   JOURNAL OF CONTROLLED RELEASE

Nanosystem drug targeting: Facing up to complex realities

(2009) Pakatip Ruenraroengsak et al.   JOURNAL OF CONTROLLED RELEASE

Numerical Study of Thermally Targeted Liposomal Drug Delivery in Tumor

(2009) Aili Zhang et al.   JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin

(2009) Jason Park et al.   Nanomedicine-Nanotechnology Biology and Medicine

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

3-D Tissue Culture Systems for the Evaluation and Optimization of Nanoparticle-Based Drug Carriers

(2008) Thomas Tyrel Goodman et al.   BIOCONJUGATE CHEMISTRY

A review of stimuli-responsive nanocarriers for drug and gene delivery

(2008) Srinivas Ganta et al.   JOURNAL OF CONTROLLED RELEASE

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

(2008) Paolo Decuzzi et al.   PHARMACEUTICAL RESEARCH

Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

(2008) Lily Yang et al.   Small

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line

(2008) Martin J.D. Clift et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS