标题
Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 1, Pages 728
出版商
MDPI AG
发表日期
2023-01-02
DOI
10.3390/ijms24010728
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Sirtuin 3: Emerging therapeutic target for cardiovascular diseases
- (2022) Mengfei Cao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Development of a single-step fluorogenic sirtuin assay and its applications for high-throughput screening
- (2022) Pan Wang et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons
- (2022) Qingxia Huang et al. Journal of Ginseng Research
- SIRT4 Is Highly Expressed in Retinal Müller Glial Cells
- (2022) Wei Wei et al. Frontiers in Neuroscience
- Correlations between serum sirtuin levels and cardiovascular risk factors in women with polycystic ovary syndrome
- (2022) Beata Charążka et al. Advances in Medical Sciences
- Drosophila Sirtuin 6 mediates developmental diet‐dependent programming of adult physiology and survival
- (2022) Namrata Shukla et al. AGING CELL
- Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle
- (2022) Fang Chen et al. Animal
- Obesity II: Establishing causal links between chemical exposures and obesity
- (2022) Jerrold J. Heindel et al. BIOCHEMICAL PHARMACOLOGY
- Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity
- (2022) Mahmut Gozelle et al. BIOORGANIC CHEMISTRY
- Sirtuin 7 serves as a promising therapeutic target for cardiorenal diseases
- (2022) Xue-Ting Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Overexpression of SLC25A51 promotes hepatocellular carcinoma progression by driving aerobic glycolysis through activation of SIRT5
- (2022) Lu Bai et al. FREE RADICAL BIOLOGY AND MEDICINE
- An evolutionary perspective on stress responses, damage and repair
- (2022) Barbara Taborsky et al. HORMONES AND BEHAVIOR
- Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways
- (2022) Gamal A. Mohamed et al. JOURNAL OF ETHNOPHARMACOLOGY
- Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation by Modulating Toll-Like Receptor 2‒NF-κB Signaling
- (2022) Guo Li et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice
- (2022) Manas Kinra et al. METABOLIC BRAIN DISEASE
- Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1
- (2022) Che Bian et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets
- (2022) Mandy O. J. Grootaert et al. Nature Reviews Cardiology
- Mitochondrial Sirtuins in Parkinson’s Disease
- (2022) Ling He et al. NEUROCHEMICAL RESEARCH
- Involvement of sirtuins (Sirt1 and Sirt3) and aryl hydrocarbon receptor (AhR) in the effects of triclosan (TCS) on production of neurosteroids in primary mouse cortical neurons cultures
- (2022) Konrad A. Szychowski et al. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
- Sonochemical Synthesis and In Silico Evaluation of Imidazo[1,2-a]Pyridine Derivatives as Potential Inhibitors of Sirtuins
- (2022) Sidda Ramarao et al. POLYCYCLIC AROMATIC COMPOUNDS
- Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary
- (2022) Kirthiram K. Sivakumar et al. REPRODUCTIVE TOXICOLOGY
- SIRT4 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the AKT/mTOR/Autophagy Pathway
- (2022) Ling He et al. TOXICOLOGY
- Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation
- (2022) Xue Li et al. Translational Research
- Antioxidant Supplementation Hinders the Role of Exercise Training as a Natural Activator of SIRT1
- (2022) Carmine Sellitto et al. Nutrients
- Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6
- (2022) Noriyuki Okudaira et al. Scientific Reports
- Pharmacological Effects of Gami-Yukmijihwang-Tang on the Lipopolysaccharide-Induced Hippocampus Oxidation and Inflammation via Regulation of Sirt6
- (2022) Jie-Yoon Kang et al. Pharmaceuticals
- Regulation of mitochondrial function by forkhead transcription factors
- (2022) Maria Sona Jerome et al. BIOCHIMIE
- Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase
- (2022) Sarah Zähringer et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and Evaluation of Benzoylbenzofurans and Isoflavone Derivatives as Sirtuin 1 Inhibitors with Antiproliferative Effects on Cancer Cells
- (2022) Mamoalosi A. Selepe et al. BIOORGANIC CHEMISTRY
- Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats
- (2022) Xiangrong Chen et al. BRAIN RESEARCH BULLETIN
- Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3
- (2022) Qing Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Antagonistic Pharmacological Interaction between Sirtuin Inhibitor Cambinol and Paclitaxel in Triple-Negative Breast Cancer Cell Lines: An Isobolographic Analysis
- (2022) Anna Wawruszak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice
- (2022) Xing-Yuan Zhao et al. NEUROREPORT
- SIRT5 is involved in the proliferation and metastasis of breast cancer by promoting aerobic glycolysis
- (2022) Shuai He et al. PATHOLOGY RESEARCH AND PRACTICE
- Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
- (2022) Yue Sun et al. Redox Biology
- Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of Amyotrophic lateral sclerosis
- (2022) Yujun Zhou et al. Acta Pharmaceutica Sinica B
- Complex interactions between nicotine and resveratrol in the Drosophila melanogaster wing spot test
- (2022) N.A. Velázquez-Ulloa et al. Heliyon
- Sirtuins as novel pharmacological targets in podocyte injury and related glomerular diseases
- (2022) Tongtong Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Sirt3 mediates the benefits of exercise on bone in aged mice
- (2022) Qiangqiang Li et al. CELL DEATH AND DIFFERENTIATION
- Theacrine ameliorates experimental liver fibrosis in rats by lowering cholesterol storage via activation of the Sirtuin 3-farnesoid X receptor signaling pathway
- (2022) Xi-Ting Lv et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Stimulating the sir2–spargel axis rescues exercise capacity and mitochondrial respiration in a Drosophila model of Barth syndrome
- (2022) Deena Damschroder et al. Disease Models & Mechanisms
- Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation
- (2022) Xin Chou et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors
- (2022) Yanghan Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression
- (2022) Daofeng Zheng et al. EXPERIMENTAL CELL RESEARCH
- Hollow fiber membrane-protected amino/hydroxyl bifunctional microporous organic network fiber for solid-phase microextraction of bisphenols A, F, S, and triclosan in breast milk and infant formula
- (2022) Shihuan Li et al. FOOD CHEMISTRY
- Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation
- (2022) Young Hyun Jung et al. FREE RADICAL BIOLOGY AND MEDICINE
- Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization
- (2022) Hai-Li Bao et al. Hepatobiliary & Pancreatic Diseases International
- Bioinformatic analysis of SIRT7 sequence and structure
- (2022) Francisco Alejandro Lagunas-Rangel JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Pharmacological features, health benefits and clinical implications of honokiol
- (2022) Fatima Khatoon et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Sirtuin Evolution at the Dawn of Animal Life
- (2022) David A Gold et al. MOLECULAR BIOLOGY AND EVOLUTION
- Spinal Sirtuin 3 Contributes to Electroacupuncture Analgesia in Mice with Chronic Constriction Injury–Induced Neuropathic Pain
- (2022) Yidan Zhang et al. NEUROMODULATION
- Changes in circulating sirtuin 1 after bariatric surgery
- (2022) Trine B. Opstad et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Polydatin prevents lipotoxicity-induced dysfunction in pancreatic β-cells by inhibiting endoplasmic reticulum stress and excessive autophagy
- (2022) Wenqi Jin et al. PHYTOMEDICINE
- Sirtuin 7 is essential for the survival and synthesis of estrogen in Yak ( Bos grunniens ) cumulus granulosa cells
- (2022) Shaoshuai Gao et al. REPRODUCTION IN DOMESTIC ANIMALS
- Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-κB signaling pathway
- (2022) Juan Zhao et al. Reproductive Biology
- Role of Sirtuins in Physiology and Diseases of the Central Nervous System
- (2022) Justyna Chojdak-Łukasiewicz et al. Biomedicines
- Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway
- (2022) Shan Ye et al. BEHAVIOURAL BRAIN RESEARCH
- Hyperacetylation of the C-terminal domain of p53 inhibits the formation of the p53/p21 complex
- (2022) Ukjin Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI
- (2022) Dong Yu et al. BRAIN RESEARCH
- Temporal trends in risk of bisphenol A, benzophenone-3 and triclosan exposure among U.S. children and adolescents aged 6–19 years: Findings from the National Health and Nutrition Examination Survey 2005–2016
- (2022) Ruiqiang Li et al. ENVIRONMENTAL RESEARCH
- Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- (2022) Ling-li Chen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Ergothioneine and its prospects as an anti-ageing compound
- (2022) Yasaaswini Apparoo et al. EXPERIMENTAL GERONTOLOGY
- Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
- (2022) Xue-Ting Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1α-NFκB pathway in bovine mammary epithelial cells
- (2022) Lei Liu et al. JOURNAL OF DAIRY SCIENCE
- Endothelial SIRT6 deficiency promotes arterial thrombosis in mice
- (2022) Daniel S. Gaul et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- NAD+ metabolism in peripheral neuropathic pain
- (2022) Yi Dai et al. NEUROCHEMISTRY INTERNATIONAL
- Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling
- (2022) Qing Zhang et al. PHYTOMEDICINE
- In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection
- (2022) Matías E. Rodriguez et al. International Journal for Parasitology-Drugs and Drug Resistance
- SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease
- (2022) Chih-Chang Chao et al. Redox Biology
- Role of FoxO1 and insulin on cell proliferation mediated by Sirt1 in goose primary hepatocytes
- (2021) Rongxue Wei et al. JOURNAL OF APPLIED POULTRY RESEARCH
- Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease
- (2021) Song Du et al. LIFE SCIENCES
- Sirtuin 1 inhibitor EX527 suppresses morphine-induced behavioral sensitization
- (2021) Lai Wei et al. NEUROSCIENCE LETTERS
- Sirtuins—The New Important Players in Women’s Gynecological Health
- (2021) Ewa Maria Kratz et al. Antioxidants
- Sirtuin-dependent recovery from aerial heat shock: The effects of food ration, thermal history, and sirtuin inhibition on clearance rates and valve gape activity of the California mussel, Mytilus californianus (Conrad)
- (2021) Melissa A. May et al. JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
- Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease
- (2021) Manoj Govindarajulu et al. NEUROCHEMISTRY INTERNATIONAL
- The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
- (2021) Christian Griñán-Ferré et al. AGEING RESEARCH REVIEWS
- Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways
- (2021) Haoren Qin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery and characterization of small molecule SIRT3-specific inhibitors as revealed by mass spectrometry
- (2021) Saurabh Loharch et al. BIOORGANIC CHEMISTRY
- Mitochondrial Sirtuins in Stem cells and Cancer
- (2021) Amit Jaiswal et al. FEBS Journal
- Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
- (2021) John A. Collins et al. FREE RADICAL BIOLOGY AND MEDICINE
- An updated pharmacological insight of resveratrol in the treatment of diabetic nephropathy
- (2021) Ke-Xue Li et al. GENE
- The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients
- (2021) Veronica Bordoni et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor
- (2021) Vittoria Borgonetti et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis
- (2021) Yu Liu et al. LIFE SCIENCES
- Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy
- (2021) Xavier Palomer et al. TRENDS IN MOLECULAR MEDICINE
- SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes
- (2021) Francesca Molinari et al. Cells
- SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor
- (2021) Zhicheng Sun et al. BIOMEDICINE & PHARMACOTHERAPY
- Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis
- (2021) Chiaki Yamada et al. BIOMEDICINE & PHARMACOTHERAPY
- The role of sirtuin 1 on the induction of trained immunity
- (2021) Vera P. Mourits et al. CELLULAR IMMUNOLOGY
- DeepSIRT: A deep neural network for identification of sirtuin targets and their subcellular localizations
- (2021) Syed Muazzam Ali Shah et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective
- (2021) Vishal Kumar et al. Current Neuropharmacology
- Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress
- (2021) Y. Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression
- (2021) Tuo Hu et al. GASTROENTEROLOGY
- Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine
- (2021) Norihiro Okada et al. GENE
- Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells
- (2021) Lei Liu et al. JOURNAL OF DAIRY SCIENCE
- BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells
- (2021) Yi Jer Tan et al. LIFE SCIENCES
- Sirtuin 6: linking longevity with genome and epigenome stability
- (2021) Anatoly Korotkov et al. TRENDS IN CELL BIOLOGY
- Sirtuins as Potential Therapeutic Targets for Mitigating Neuroinflammation Associated With Alzheimer’s Disease
- (2021) Kurukulasooriya Kavindya Madushani Fernando et al. Frontiers in Cellular Neuroscience
- SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
- (2021) Elma Zaganjor et al. Cell Reports
- A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review
- (2021) Marziyeh Najafi et al. Diabetes & Metabolic Syndrome-Clinical Research & Reviews
- Characterization of the SIRT genes and their distinct expression patterns in Manila clams (Ruditapes philippinarum) exposed to air
- (2021) Jingtian Wang et al. Meta Gene
- Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection
- (2021) Takashi Tanikawa et al. Journal of Traditional and Complementary Medicine
- Role of mitochondrial sirtuins in rheumatoid arthritis
- (2021) Muhmmad Zahid Hussain et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Sirtuin 6 regulates macrophage polarization to alleviate sepsis-induced acute respiratory distress syndrome via dual mechanisms dependent on and independent of autophagy
- (2021) Qian-Lu Wang et al. CYTOTHERAPY
- Comprehensive insight into triclosan—from widespread occurrence to health outcomes
- (2021) Maja Milanović et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates
- (2021) Fan Yang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- FOXM1-activated SIRT4 inhibits NF-κB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy
- (2021) Xiaohong Xu et al. EXPERIMENTAL CELL RESEARCH
- GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis
- (2021) Ding Wang et al. EXPERIMENTAL CELL RESEARCH
- Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?
- (2021) Francesco Visioli et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study
- (2021) Ishrat Mahjabeen et al. GENE
- Cloning, biochemical characterization and molecular docking of novel thermostable β-glucosidase BglA9 from Anoxybacillus ayderensis A9 and its application in de-glycosylation of Polydatin
- (2021) Numan Saleh Zada et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the C. elegans Model
- (2021) Anam Naseer et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Development of a novel UPLC-MS/MS method for the simultaneously quantification of polydatin and resveratrol in plasma: Application to a pharmacokinetic study in rats
- (2021) Robin Sunsong et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Effect of extracts and isolated compounds derived from Retama monosperma (L.) Boiss. on anti-aging gene expression in human keratinocytes and antioxidant activity
- (2021) Manal Zefzoufi et al. JOURNAL OF ETHNOPHARMACOLOGY
- Mitochondrial sirtuins, metabolism, and aging
- (2021) Zhejun Ji et al. Journal of Genetics and Genomics
- The role of Sirtuin 2 in sustaining functional integrity of the liver
- (2021) SunYoung Park et al. LIFE SCIENCES
- Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies
- (2021) Khairy A. Ibrahim et al. LIFE SCIENCES
- The age-dependent variations for fatty acid composition and sensory quality of chicken meat and associations between gene expression patterns and meat quality
- (2021) Jingjing Li et al. Livestock Science
- The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective
- (2021) Sajad Fakhri et al. MOLECULES
- Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved
- (2021) C.A. Miguel et al. NEUROCHEMISTRY INTERNATIONAL
- Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice
- (2021) Zhi-Peng Xiao et al. STROKE
- Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 signaling
- (2021) Ghedeir M. Alshammari et al. Journal of Functional Foods
- Sirtuin Modulators in Cellular and Animal Models of Human Diseases
- (2021) Jun Young Hong et al. Frontiers in Pharmacology
- Sirtuins at the Service of Healthy Longevity
- (2021) Mateusz Watroba et al. Frontiers in Physiology
- Human Sirtuin Regulators: The “Success” Stories
- (2021) Alyson M. Curry et al. Frontiers in Physiology
- Nuclear Sirtuins and the Aging of the Immune System
- (2021) Andrés Gámez-García et al. Genes
- Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib
- (2021) Hua-Li Wang et al. PHARMACOLOGICAL RESEARCH
- Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats
- (2020) Yifan Tong et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery
- (2020) Ling-Ling Yang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies
- (2020) Sarwat Chowdhury et al. MOLECULES
- Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis
- (2020) Hanna E. Teasley et al. Reproductive Sciences
- Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats
- (2020) Amit Kundu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
- (2020) Matthew J. G. Eldridge et al. Scientific Reports
- Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet
- (2020) Mohamed A. Ahmed et al. Frontiers in Oncology
- Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
- (2020) Jing-Ying Lin et al. Aging-US
- Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines
- (2020) Varunkumar Krishnamoorthy et al. GENOMICS
- Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes
- (2020) Richard Sejour et al. G3-Genes Genomes Genetics
- Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice
- (2020) Rong Hua et al. Asian Journal of Surgery
- Inhibiting protein kinase activity of pyruvate kinase M2 by sirtuin 2 deacetylase attenuates psoriasis
- (2020) Lihua Hao et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a Sirtuin 1-dependent manner
- (2020) Hyunju Kang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis
- (2020) Parvej Ahmad et al. LIFE SCIENCES
- Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm, Bombyx mori
- (2020) Jiangbo Song et al. Journal of Pharmaceutical Analysis
- Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents
- (2020) Hanna Laaroussi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sirtuins as endogenous regulators of lung fibrosis: A current perspective
- (2020) Somnath Mazumder et al. LIFE SCIENCES
- Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer
- (2020) Heverton Leandro Carneiro Dutra et al. PLoS Pathogens
- Energy metabolism disorders and potential therapeutic drugs in heart failure
- (2020) Yanan He et al. Acta Pharmaceutica Sinica B
- Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)
- (2020) Shuang Bao et al. AQUATIC TOXICOLOGY
- Sirtuin 5 promotes arterial thrombosis through endothelial plasminogen activator inhibitor-1
- (2020) L. Liberale et al. ATHEROSCLEROSIS
- Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive
- (2020) Neoma T. Boardman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- p53-dependent glutamine usage determines susceptibility to oxidative stress in radioresistant head and neck cancer cells
- (2020) Hyo Won Chang et al. CELLULAR SIGNALLING
- Resveratrol and cardiovascular system—the unfulfilled hopes
- (2020) Małgorzata Chudzińska et al. IRISH JOURNAL OF MEDICAL SCIENCE
- Nitro-fatty acids as activators of hSIRT6 deacetylase activity
- (2020) Mara Carreño et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis
- (2020) Yuanqi Yang et al. CHEMOSPHERE
- Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells
- (2020) María Paula Ceballos et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Immunometabolic control of hematopoiesis
- (2020) George Hajishengallis et al. MOLECULAR ASPECTS OF MEDICINE
- Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay
- (2020) Juan Hu et al. TALANTA
- Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis
- (2020) Shanchao Wang et al. Molecular Therapy-Nucleic Acids
- A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
- (2020) Tailin He et al. Acta Pharmaceutica Sinica B
- Protective effects of polydatin against sulfur mustard-induced hepatic injury
- (2019) Hao Zhang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Roles of Mitochondrial SIRT4 in Cellular Metabolism
- (2019) Zheying Min et al. Frontiers in Endocrinology
- Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
- (2019) Hisayuki Amano et al. Cell Metabolism
- Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α
- (2019) Young Jae Moon et al. CELL DEATH AND DIFFERENTIATION
- Role of N-terminus in function and dynamics of sirtuin 7: an in silico study
- (2019) Marta Hałasa et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle
- (2019) Katya Vargas-Ortiz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses
- (2019) Brent A. Hackett et al. mBio
- Current role of mammalian sirtuins in DNA repair
- (2019) Francisco Alejandro Lagunas-Rangel DNA REPAIR
- Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
- (2019) Kyeong-Eun Yang et al. Journal of Ginseng Research
- Update on the role of Sirtuin 3 in cell differentiation: A major metabolic target that can be pharmacologically controlled
- (2019) Julie Storder et al. BIOCHEMICAL PHARMACOLOGY
- A scaffold replacement approach towards new sirtuin 2 inhibitors
- (2019) Tina Seifert et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice
- (2019) Catherine Yzydorczyk et al. Nutrients
- 1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1
- (2019) Yuxin Song et al. BIOMEDICINE & PHARMACOTHERAPY
- Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors
- (2019) Nadia A. Khalil et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines
- (2019) Masaya Igase et al. EXPERIMENTAL CELL RESEARCH
- SIRT4 is the last puzzle of mitochondrial sirtuins
- (2018) Yan Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A ternary complex model of Sirtuin4-NAD + -Glutamate dehydrogenase
- (2018) Yusuke Kato et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure
- (2018) Satoru Yanagisawa et al. PLoS One
- Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster
- (2018) Jason G. Wood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos
- (2018) Jiahua Guo et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease
- (2018) A. Hadar et al. Scientific Reports
- Genetic and epigenetic regulation of human aging and longevity
- (2018) Brian J. Morris et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation
- (2018) Y. Si et al. BRITISH JOURNAL OF ANAESTHESIA
- Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation
- (2018) Sara Nikseresht et al. JOURNAL OF CELLULAR PHYSIOLOGY
- SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRα pathways in bovine ovarian granular cells
- (2018) Dejun Xu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Oxidative nucleophilic substitution selectively produces cambinol derivatives with antiproliferative activity on bladder cancer cell lines
- (2018) Lorenzo Botta et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
- (2018) Yijie Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sirtuin 2 mutations in human cancers impair its function in genome maintenance
- (2017) PamelaSara E. Head et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition
- (2017) Kun Cao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Oroxylin A reduces angiotensin II- induced hypertrophy and mitochondrial dysfunction by activating sirtuin 3 in cardiac myocytes
- (2017) Niria Treviño Saldaña et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Emerging Roles of Sirtuin 6 in Alzheimer’s Disease
- (2017) Nurul Fatihah Mohamad Nasir et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Analysis of Polymorphisms in 58 Potential Candidate Genes for Association with Human Longevity
- (2017) Timothy A Donlon et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Mitochondrial Sirtuins and Molecular Mechanisms of Aging
- (2017) Robert A.H. van de Ven et al. TRENDS IN MOLECULAR MEDICINE
- Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- (2017) Lian-Xiang Luo et al. Frontiers in Pharmacology
- Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization
- (2016) Wenlong Bai et al. CELL CYCLE
- SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling
- (2016) Hu Wang et al. Cell Stem Cell
- SIRT3gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle
- (2016) Brittany A. Edgett et al. EXPERIMENTAL PHYSIOLOGY
- Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice
- (2016) R. Mastrocola et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6
- (2016) Nunzia D’Onofrio et al. FREE RADICAL BIOLOGY AND MEDICINE
- Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust
- (2016) Siyuan Guo et al. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells
- (2016) Ying Hui Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuins in metabolism, DNA repair and cancer
- (2016) Zhen Mei et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The role of sirtuins in cellular homeostasis
- (2016) Wioleta Kupis et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Targeting Sirtuin-1 prolongs murine renal allograft survival and function
- (2016) Matthew H. Levine et al. KIDNEY INTERNATIONAL
- The sirtuins, oxidative stress and aging: an emerging link
- (2016) Philip I. Merksamer et al. Aging-US
- Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
- (2015) Rute Martins et al. AGING CELL
- Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone/insulin-like growth factor-1 status
- (2015) Silvia Savastano et al. GROWTH HORMONE & IGF RESEARCH
- Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia
- (2015) Sharda Kumari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway
- (2015) Ling Zhou et al. Journal of Translational Medicine
- Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium
- (2015) Carla Bartosch et al. Oncotarget
- SIRT4 inhibits cigarette smoke extracts-induced mononuclear cell adhesion to human pulmonary microvascular endothelial cells via regulating NF-κB activity
- (2014) Yongfeng Chen et al. TOXICOLOGY LETTERS
- SIRT1 and other sirtuins in metabolism
- (2014) Hung-Chun Chang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
- (2013) Jérôme Lugrin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
- (2013) Susan Costantini et al. BMC EVOLUTIONARY BIOLOGY
- A Novel Sirtuin 2 (SIRT2) Inhibitor with p53-dependent Pro-apoptotic Activity in Non-small Cell Lung Cancer
- (2013) Gesine Hoffmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
- (2013) Ning Xia et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Strategies and future trends to identify the mode of action of phytotoxic compounds
- (2013) Stefan Tresch PLANT SCIENCE
- Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity
- (2013) Elsa Vera et al. PLoS One
- Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
- (2013) M. Gertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages
- (2012) Cláudia A. Fernandes et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- GADD45 Proteins: Central Players in Tumorigenesis
- (2012) R. E. Tamura et al. CURRENT MOLECULAR MEDICINE
- Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal Cells
- (2012) Zhipeng Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
- (2012) Yeyun Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle
- (2011) Zsolt Radak et al. FREE RADICAL BIOLOGY AND MEDICINE
- Protective effects and mechanisms of sirtuins in the nervous system
- (2011) Feng Zhang et al. PROGRESS IN NEUROBIOLOGY
- Aging Genes: The Sirtuin Story Unravels
- (2011) J. Couzin-Frankel SCIENCE
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer
- (2010) Yolanda Olmos et al. DRUG RESISTANCE UPDATES
- A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms
- (2010) Jonathan P. Little et al. JOURNAL OF PHYSIOLOGY-LONDON
- Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
- (2009) Kenichi Kakefuda et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Structural basis for sirtuin function: What we know and what we don't
- (2009) Brandi D. Sanders et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Sirtuin activators
- (2009) Francisco J Alcaín et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis
- (2008) S. Greiss et al. GENES & DEVELOPMENT
- Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
- (2008) Carl Julien et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now