Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

(2017) Sandeep Sundriyal et al.   JOURNAL OF MEDICINAL CHEMISTRY

A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity

(2016) Hui Jing et al.   CANCER CELL

SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation

(2016) Shuang-Nian Xu et al.   Scientific Reports

The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer

(2016) Wenhui Zhou et al.   Cell Reports

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors

(2014) Sumit S. Mahajan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach

(2014) Huaqing Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT2, une déacétylase aux multiples talents

(2014) Salwa Sayd et al.   M S-MEDECINE SCIENCES

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma

(2013) J. E. Amengual et al.   BLOOD

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

A Novel Sirtuin 2 (SIRT2) Inhibitor with p53-dependent Pro-apoptotic Activity in Non-small Cell Lung Cancer

(2013) Gesine Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS

(2013) M. H. Yang et al.   MOLECULAR CANCER RESEARCH

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

(2012) P Y Liu et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Prognostic significance of sirtuin 2 protein nuclear localization in glioma: An immunohistochemical study

(2012) NATSUKO IMAOKA et al.   ONCOLOGY REPORTS

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

SIRT2 as a Therapeutic Target for Age-Related Disorders

(2012) Rita Machado de Oliveira et al.   Frontiers in Pharmacology

SIRT2 activity is required for the survival of C6 glioma cells

(2011) Xin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases

(2011) Federico Medda et al.   MedChemComm

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

(2010) Yanze Li et al.   GENES TO CELLS

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

(2008) Robert C. Neugebauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

The SIRT2 Deacetylase Regulates Autoacetylation of p300

(2008) Joshua C. Black et al.   MOLECULAR CELL