Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways

Summary of Natural Products Ameliorate Concanavalin A-Induced Liver Injury: Structures, Sources, Pharmacological Effects, and Mechanisms of Action

(2021) Sabrin R. M. Ibrahim et al.   Plants-Basel

Cucurbitacin II a: A review of phytochemistry and pharmacology

(2021) Yijia Zeng et al.   PHYTOTHERAPY RESEARCH

Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition

(2021) Maha H. Sharawy et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Terretonin as a New Protective Agent against Sepsis-Induced Acute Lung Injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 Signaling

(2021) Gamal A. Mohamed et al.   Biology-Basel

Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling

(2020) Miao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT1/IGFBPrP1/TGF β1 axis involved in cucurbitacin B ameliorating concanavalin A‐induced mice liver fibrosis

(2020) Li Yang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Nor-cucurbitacins from the leaves of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae)

(2020) Gnaoré Yoh Toussaint Douhoré et al.   FITOTERAPIA

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation

(2019) Xiang-Ping Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Amygdalin (Vitamin B17) pretreatment attenuates experimentally induced acute autoimmune hepatitis through reduction of CD4+ cell infiltration

(2019) Wael M Elsaed   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Cucurbitacin E glucoside from Citrullus colocynthis inhibits testosterone-induced benign prostatic hyperplasia in mice

(2019) Salsabeel Z. Basha et al.   DRUG AND CHEMICAL TOXICOLOGY

Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia

(2019) Taieb Tounekti et al.   Evidence-based Complementary and Alternative Medicine

Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways

(2019) Rui Sang et al.   Artificial Cells Nanomedicine and Biotechnology

Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling

(2019) Jin Shang et al.   MOLECULAR IMMUNOLOGY

Glycyrrhizic acid ammonium salt alleviates Concanavalin A-induced immunological liver injury in mice through the regulation of the balance of immune cells and the inhibition of hepatocyte apoptosis

(2019) Xiaohui Tian et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effects of Punica granatum (pomegranate) peel extract on concanavalin A-induced autoimmune hepatitis in mice

(2018) Tingting Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-κB and Nrf2 signaling pathways

(2018) Huan-Huan Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis

(2018) Dina S. El-Agamy et al.   Frontiers in Pharmacology

Hepatoprotective Effect of San-Cao Granule on Con A-Induced Liver Injury in Mice and Mechanisms of Action Exploration

(2018) YuXue Yang et al.   Frontiers in Pharmacology

NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

(2018) Jingyun Luan et al.   Frontiers in Immunology

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

(2017) Tse-Hung Huang et al.   Scientific Reports

Alpha-lipoic acid protects mice against concanavalin A-induced hepatitis by modulating cytokine secretion and reducing reactive oxygen species generation

(2016) Miaomiao Fei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice

(2016) Kaiping Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pirfenidone ameliorates concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways

(2016) Dina S. El-Agamy   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

(2016) JUN REN et al.   Molecular Medicine Reports

Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF- B signaling

(2015) L. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Emodin Protects Against Concanavalin A-Induced Hepatitis in Mice Through Inhibiting Activation of the p38 MAPK-NF-κB Signaling Pathway

(2015) Jihua Xue et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Paeoniflorin protects against concanavalin A-induced hepatitis in mice

(2015) Mingsheng Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells

(2015) Mingyi Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

(2015) Yuqing Mao et al.   Drug Design Development and Therapy

Citrullus colocynthis (L.) Schrad (bitter apple fruit): A review of its phytochemistry, pharmacology, traditional uses and nutritional potential

(2014) Abdullah I. Hussain et al.   JOURNAL OF ETHNOPHARMACOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice

(2013) Xiaomei Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Immune mechanisms of Concanavalin A model of autoimmune hepatitis

(2012) Hai-Xia Wang   WORLD JOURNAL OF GASTROENTEROLOGY

In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma

(2011) Seif-Eldin N. Ayyad et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY