Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells
出版年份 2020 全文链接
标题
Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells
作者
关键词
Hepatocellular carcinoma, Sorafenib, Sirtuins, HCC cell lines, EX-527, Spheroids
出版物
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 892, Issue -, Pages 173736
出版商
Elsevier BV
发表日期
2020-11-19
DOI
10.1016/j.ejphar.2020.173736
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular therapies for HCC: Looking outside the box
- (2020) Sandrine Faivre et al. JOURNAL OF HEPATOLOGY
- SOX9 enhances sorafenib resistance through upregulating ABCG2 expression in hepatocellular carcinoma
- (2020) Mengchao Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1
- (2019) Antje Garten et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ubiquitin-Specific Protease 22/Silent Information Regulator 1 Axis Plays a Pivotal Role in the Prognosis and 5-Fluorouracil Resistance in Hepatocellular Carcinoma
- (2019) Xue Wen et al. DIGESTIVE DISEASES AND SCIENCES
- Ibrutinib potentiates anti-hepatocarcinogenic efficacy of sorafenib by targeting EGFR in tumor cells and BTK in immune cells in the stroma
- (2019) Cho-Hao Lin et al. MOLECULAR CANCER THERAPEUTICS
- ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma
- (2018) Maria Paula Ceballos Mancini et al. CURRENT MEDICINAL CHEMISTRY
- Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response
- (2018) Xiaomin Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines
- (2018) María Paula Ceballos et al. TOXICOLOGY LETTERS
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
- (2018) Sigrid A. Langhans Frontiers in Pharmacology
- Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma
- (2018) Iftikhar Ali Khawar et al. NEOPLASIA
- The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
- (2018) Anna Baulies et al. Redox Biology
- Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents
- (2017) Giovanni Luca Beretta et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
- (2017) G Chen et al. ONCOGENE
- Personalized therapy in hepatocellular carcinoma: Molecular markers of prognosis and therapeutic response
- (2017) Richard A. Burkhart et al. SURGICAL ONCOLOGY-OXFORD
- High-Content Monitoring of Drug Effects in a 3D Spheroid Model
- (2017) Frédérique Mittler et al. Frontiers in Oncology
- Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo
- (2017) Hong-Ryul Jung et al. Scientific Reports
- Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL)
- (2016) Savita Bhalla et al. CANCER BIOLOGY & THERAPY
- MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma
- (2016) Tetsu Tomonari et al. Oncotarget
- SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
- (2016) Yuming Li et al. Oncotarget
- Safety, pharmacokinetics, pharmacogenomics and QT concentration−effect modelling of the SirT1 inhibitor selisistat in healthy volunteers
- (2015) Goran Westerberg et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease
- (2015) Sigurd D. Süssmuth et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma
- (2015) Jiang Chen et al. CANCER LETTERS
- Molecular mechanisms of drug resistance and its reversal in cancer
- (2015) Melis Kartal-Yandim et al. CRITICAL REVIEWS IN BIOTECHNOLOGY
- Sorafenib: 10 years after the first pivotal trial
- (2015) Gennaro Gadaleta-Caldarola et al. Future Oncology
- Sensitization of Chemo-Resistant Human Chronic Myeloid Leukemia Stem-Like Cells to Hsp90 Inhibitor by SIRT1 Inhibition
- (2015) Hak-Bong Kim et al. International Journal of Biological Sciences
- Gain-of-function p53 mutant with 21-bp deletion confers susceptibility to multidrug resistance in MCF-7 cells
- (2015) SHANG-HSUN TSOU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target
- (2015) Ryoichi Asaka et al. LABORATORY INVESTIGATION
- Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target
- (2015) Yuting Wu et al. TUMOR BIOLOGY
- Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells
- (2015) Sapna Singh et al. TUMOR BIOLOGY
- Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma
- (2015) Xiufeng Jiang et al. Oncotarget
- Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
- (2015) Hak-Bong Kim et al. Oncotarget
- Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
- (2015) Chong Hao et al. BMC CANCER
- Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2
- (2015) Chris K. Sun et al. NEOPLASIA
- Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway
- (2014) Guofang Wu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
- (2014) Wei-Chien Huang et al. PLoS One
- The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
- (2013) Jérôme Lugrin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D
- (2013) Jennifer Laurent et al. BMC CANCER
- SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling
- (2013) Juan Chen et al. HEPATOLOGY
- Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
- (2013) S. Portmann et al. MOLECULAR CANCER THERAPEUTICS
- SIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer Cells
- (2013) Hoo-Kyun Choi et al. MOLECULAR PHARMACEUTICS
- MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
- (2013) H J Bae et al. ONCOGENE
- The Enhanced Metastatic Potential of Hepatocellular Carcinoma (HCC) Cells with Sorafenib Resistance
- (2013) Ariel Ka-Man Chow et al. PLoS One
- Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
- (2013) M. Gertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
- (2012) Maria Vinci et al. BMC BIOLOGY
- Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
- (2012) Geeta Mehta et al. JOURNAL OF CONTROLLED RELEASE
- Overexpression of SIRT2 contributes tumor cell growth in hepatocellular carcinomas
- (2012) Hong Jian Xie et al. Molecular & Cellular Toxicology
- SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
- (2012) Kyu Yun Jang et al. PLoS One
- SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
- (2011) Hsieh-Cheng Chen et al. ANNALS OF SURGICAL ONCOLOGY
- Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth
- (2011) J. Chen et al. CANCER RESEARCH
- Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Mediates Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells
- (2011) K.-F. Chen et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
- (2011) Glenn M. Marshall et al. PLoS Genetics
- Multicellular tumor spheroids: An underestimated tool is catching up again
- (2010) Franziska Hirschhaeuser et al. JOURNAL OF BIOTECHNOLOGY
- Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation
- (2010) J. S. Lagas et al. MOLECULAR CANCER THERAPEUTICS
- SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
- (2010) Barrie Peck et al. MOLECULAR CANCER THERAPEUTICS
- SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
- (2010) K. R. Holloway et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spheroid-based drug screen: considerations and practical approach
- (2009) Juergen Friedrich et al. Nature Protocols
- SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
- (2008) X.-J. Liang et al. MOLECULAR CANCER RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started