Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Regulatory Role of Proteasome in Determination of Platelet Life Span

(2013) Manasa K. Nayak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6 controls the kinetics of platelet activation

(2012) K. Sadoul et al.   BLOOD

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

(2012) B. F. Kraemer et al.   BLOOD

Platelets increase the proliferation of ovarian cancer cells

(2012) M. S. Cho et al.   BLOOD

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells

(2012) Tomohiro Kozako et al.   INTERNATIONAL JOURNAL OF CANCER

From Sirtuin Biology to Human Diseases: An Update

(2012) Carlos Sebastián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

(2011) M. J. Bishton et al.   BLOOD

Melatonin elevates intracellular free calcium in human platelets by inositol 1,4,5-trisphosphate independent mechanism

(2011) Sharda Kumari et al.   FEBS LETTERS

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic potential of activators and inhibitors of sirtuins

(2010) Aneta Balcerczyk et al.   BIOFACTORS

Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

(2010) Chunyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tale of Protein Lysine Acetylation in the Cytoplasm

(2010) Karin Sadoul et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase

(2009) Fu-Chao Liu et al.   BIOCHEMICAL PHARMACOLOGY

Mechanisms of resveratrol-induced platelet apoptosis

(2009) K. H. Lin et al.   CARDIOVASCULAR RESEARCH

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions

(2009) Hirohito Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Resveratrol Induces Apoptosis through ROS-Dependent Mitochondria Pathway in HT-29 Human Colorectal Carcinoma Cells

(2008) M. Emília Juan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY