Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Which antioxidant system shapes intracellular H2O2 gradients?

(2019) Natalia M. Mishina et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes

(2019) John A. Collins et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170

(2019) Sarallah Rezazadeh et al.   NUCLEIC ACIDS RESEARCH

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

(2018) Kunhua Qin et al.   DIABETOLOGIA

Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging

(2018) Tina Oberacker et al.   FEBS LETTERS

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

(2018) Karthik Nagaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

(2018) Irene Santos-Barriopedro et al.   Nature Communications

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

(2018) Kimberly J Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

(2018) Sara Iachettini et al.   Cell Death & Disease

Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

(2018) Benjamin Steinhorn et al.   Nature Communications

Identification of a cellularly active SIRT6 allosteric activator

(2018) Zhimin Huang et al.   Nature Chemical Biology

Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling

(2018) J.A. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium

(2018) Seong Ji Woo et al.   EBioMedicine

Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes

(2017) Anusha Ratneswaran et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat

(2017) David Long et al.   Scientific Reports

SIRT6, oxidative stress and aging

(2016) Chen-Yu Liao et al.   CELL RESEARCH

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes

(2016) John A. Collins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction

(2016)   MOLECULES AND CELLS

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

(2016) Mona Dvir-Ginzberg et al.   Current Rheumatology Reports

Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis

(2015) Maierhaba Ailixiding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Posttranslational modification of Sirt6 activity by peroxynitrite

(2015) Shuqun Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

(2015) Arden Perkins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

(2015) Yaosen Wu et al.   Scientific Reports

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments

(2015) Scott T. Wood et al.   Arthritis & Rheumatology

Redox theory of aging

(2015) Dean P. Jones   Redox Biology

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin-like Growth Factor 1 and Osteogenic Protein 1

(2014) Richard F. Loeser et al.   Arthritis & Rheumatology

How Much H2O2 Is Produced by Recombinant D-Amino Acid Oxidase in Mammalian Cells?

(2013) Mikhail E. Matlashov et al.   ANTIOXIDANTS & REDOX SIGNALING

Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: correlations with anterior cruciate ligament and cartilage changes

(2012) Yadin D Levy et al.   ANNALS OF THE RHEUMATIC DISEASES

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

SIRT6 is required for maintenance of telomere position effect in human cells

(2011) Ruth I. Tennen et al.   Nature Communications

A Model of Redox Kinetics Implicates the Thiol Proteome in Cellular Hydrogen Peroxide Responses

(2010) Nnenna J. Adimora et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduction of Cysteine Sulfinic Acid in Eukaryotic, Typical 2-Cys Peroxiredoxins by Sulfiredoxin

(2010) W. Todd Lowther et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 in DNA repair, metabolism and ageing

(2010) D. B. Lombard et al.   JOURNAL OF INTERNAL MEDICINE

Regulation of Gene Expression by PI3K in Mouse Growth Plate Chondrocytes

(2010) Veronica Ulici et al.   PLoS One

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

(2009) Weihong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE