Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Crosstalk between ferroptosis and the epithelial-mesenchymal transition: implications for inflammation and cancer therapy

(2022) Nasim Ebrahimi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Sirtuin 7 serves as a promising therapeutic target for cardiorenal diseases

(2022) Xue-Ting Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

(2022) Zhenzhou Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7

(2022) Xiaotong Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

(2021) Verónica Miguel et al.   JOURNAL OF CLINICAL INVESTIGATION

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

(2021) Min Woo Park et al.   Redox Biology

Chronic kidney disease

(2021) Kamyar Kalantar-Zadeh et al.   LANCET

Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation

(2021) Sian E. Piret et al.   KIDNEY INTERNATIONAL

HDAC inhibition induces EMT and alterations in cellular iron homeostasis to augment ferroptosis sensitivity in SW13 cells

(2021) Thais Oliveira et al.   Redox Biology

Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

(2020) Shimin Sun et al.   Science Advances

The Krüppel-Like Factor 15-NFATc1 Axis Ameliorates Podocyte Injury: A Novel Rationale for Using Glucocorticoids in Proteinuria Diseases

(2020) Caoshuai Dou et al.   CLINICAL SCIENCE

Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription

(2020) Lei Mao et al.   Frontiers in Cell and Developmental Biology

MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling

(2020) Juan-Juan Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2020) Lili Sheng et al.   Frontiers in Physiology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Gender Differences in Hypertension

(2019) Juan-Juan Song et al.   Journal of Cardiovascular Translational Research

Proximal Tubule-Specific Deletion of the NHE3 (Na + /H + Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice

(2019) Xiao C. Li et al.   HYPERTENSION

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

Targeting renal fibrosis: Mechanisms and drug delivery systems

(2018) Madalina V. Nastase et al.   ADVANCED DRUG DELIVERY REVIEWS

Nox4 in Renal Diseases: An Update

(2018) Qin Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells

(2018) Kun-Lin Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

(2018) Wenlu Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease

(2018) Sanne van Raaij et al.   Scientific Reports

Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease

(2018) Yiqing Guo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms

(2017) Teresa M. Seccia et al.   JOURNAL OF HYPERTENSION

The loss of Krüppel-like factor 15 in Foxd1 + stromal cells exacerbates kidney fibrosis

(2017) Xiangchen Gu et al.   KIDNEY INTERNATIONAL

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

(2017) Xiaolong Tang et al.   Nature Communications

SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension

(2017) Na Li et al.   Oncotarget

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis

(2016) Sara Lovisa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association between renal iron accumulation and renal interstitial fibrosis in a rat model of chronic kidney disease

(2015) Yoshiro Naito et al.   HYPERTENSION RESEARCH

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

(2014) Yasumasa Ikeda et al.   PLoS One

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15

(2011) Xiang Gao et al.   KIDNEY INTERNATIONAL

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

The NRF2–heme oxygenase-1 system modulates cyclosporin A-induced epithelial–mesenchymal transition and renal fibrosis

(2010) Dong-ha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH