Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the C. elegans Model

Autophagy in Parkinson's Disease

(2020) Xu Hou et al.   JOURNAL OF MOLECULAR BIOLOGY

Glia in neurodegeneration: Drivers of disease or along for the ride?

(2020) Amy J. Gleichman et al.   NEUROBIOLOGY OF DISEASE

Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease

(2020) Zhi Dong Zhou et al.   AGEING RESEARCH REVIEWS

Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease

(2020) Yanhua Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Autophagy at synapses in neurodegenerative diseases

(2019) Wongyoung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Dual Role of Autophagy in Diseases of the Central Nervous System

(2019) Tamara Bar-Yosef et al.   Frontiers in Cellular Neuroscience

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

(2019) Yong Liu et al.   Nature Communications

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

(2019) In Hye Lee   EXPERIMENTAL AND MOLECULAR MEDICINE

Metabolic regulation of lifespan from a C. elegans perspective

(2019) Kathrine B. Dall et al.   Genes and Nutrition

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

(2019) Kathrin Schmeisser et al.   Frontiers in Cell and Developmental Biology

Autophagy induction in the treatment of Alzheimer's disease

(2019) Eran Schmukler et al.   DRUG DEVELOPMENT RESEARCH

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

(2019) Yuanbo Wu et al.   MITOCHONDRION

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

(2019) Helena Aspernig et al.   Cell Reports

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

(2019) Caroline Kumsta et al.   Nature Communications

Role of Autophagy in Parkinson’s Disease

(2018) Silvia Cerri et al.   CURRENT MEDICINAL CHEMISTRY

Presynaptic endocytic factors in autophagy and neurodegeneration

(2018) Domenico Azarnia Tehran et al.   CURRENT OPINION IN NEUROBIOLOGY

Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer’s Disease

(2018) Christopher R. Beam et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolism, neurodegeneration and epigenetics: Emerging role of Sirtuins

(2018) DafneM Silberman   Neural Regeneration Research

Deregulation of autophagy and vesicle trafficking in Parkinson’s disease

(2018) Patricia Sheehan et al.   NEUROSCIENCE LETTERS

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

(2018) Sindhu Ramesh et al.   PLoS One

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

(2018) Kathrin Schmeisser et al.   PLoS Genetics

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion

(2018) Yitian Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy: A new strategy for host-directed therapy of tuberculosis

(2018) Seungwha Paik et al.   Virulence

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

(2018) Di Wu et al.   Frontiers in Endocrinology

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

(2017) Shu-Hui Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

(2017) Songtao Li et al.   HEPATOLOGY

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

(2017) Tim E. Moors et al.   Molecular Neurodegeneration

The brain, sirtuins, and ageing

(2017) Akiko Satoh et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Neurodegenerative signaling factors and mechanisms in Parkinson's pathology

(2017) Poonam Goswami et al.   TOXICOLOGY IN VITRO

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

(2017) Caroline Kumsta et al.   Nature Communications

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sirtuins in metabolism, DNA repair and cancer

(2016) Zhen Mei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

CeNDR, theCaenorhabditis elegansnatural diversity resource

(2016) Daniel E. Cook et al.   NUCLEIC ACIDS RESEARCH

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

(2016) Aimin Qiao et al.   Oncotarget

Expanding the nematode model system: The molecular basis of inflammation and infection recovery in C. elegans

(2016) Gabriel Hendricks et al.   Virulence

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

(2016) Sara Gelino et al.   PLoS Genetics

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease

(2015) Lei Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Sirtuins in Epigenetic Regulation

(2015) Hui Jing et al.   CHEMICAL REVIEWS

Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling PathwayCLINICAL PERSPECTIVE

(2015) Satoshi Araki et al.   CIRCULATION

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

(2015) Cristina Carvalho et al.   Expert Review of Neurotherapeutics

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer’s Disease

(2015) Wenxiu Yang et al.   NEUROCHEMICAL RESEARCH

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

(2015) Cristina Carvalho et al.   Expert Review of Neurotherapeutics

A novel kinase regulates dietary restriction-mediated longevity inCaenorhabditis elegans

(2014) Manish Chamoli et al.   AGING CELL

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia

(2014) N. Yuan et al.   HAEMATOLOGICA

Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells

(2014) ZONGGANG XIE et al.   Molecular Medicine Reports

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

SIRT3: As Simple As It Seems?

(2013) David B. Lombard et al.   GERONTOLOGY

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

(2013) M. Safra et al.   JOURNAL OF CELL SCIENCE

The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

(2013) M. Jedrusik-Bode et al.   JOURNAL OF CELL SCIENCE

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases

(2013) Martina Wirth et al.   MITOCHONDRION

Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model

(2013) Aamir Nazir et al.   Molecular Neurodegeneration

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling

(2013) Federica Simeoni et al.   Scientific Reports

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

(2012) N. Gammoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

(2012) Wei-Chung Chiang et al.   PLoS Genetics

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

Norepinephrine: the next therapeutics frontier for Parkinson's disease

(2012) Peter A LeWitt   Translational Neurodegeneration

Sir-2.1 modulates ‘calorie-restriction-mediated’ prevention of neurodegeneration in Caenorhabditis elegans: Implications for Parkinson’s disease

(2011) Pooja Jadiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Parkinsonian effects of Bacopa monnieri: Insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease

(2011) Pooja Jadiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

The life span-prolonging effect of Sirtuin-1 is mediated by autophagy

(2010) Eugenia Morselli et al.   Autophagy

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

(2010) Roongpetch Keowkase et al.   NEUROPHARMACOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Reserpine ameliorates Aβ toxicity in the Alzheimer’s disease model in Caenorhabditis elegans

(2009) Upasna Arya et al.   EXPERIMENTAL GERONTOLOGY

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

(2009) Sebastian Greiss et al.   MOLECULES AND CELLS

Autophagy in Caenorhabditis elegans

(2008) Evgenia V. Megalou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA