Polydatin prevents lipotoxicity-induced dysfunction in pancreatic β-cells by inhibiting endoplasmic reticulum stress and excessive autophagy

Deficient Leptin Cellular Signaling Plays a Key Role in Brain Ultrastructural Remodeling in Obesity and Type 2 Diabetes Mellitus

(2021) Melvin R. Hayden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polydatin Reduces Cardiotoxicity and Enhances the Anticancer Effects of Sunitinib by Decreasing Pro-Oxidative Stress, Pro-Inflammatory Cytokines, and NLRP3 Inflammasome Expression

(2021) Vincenzo Quagliariello et al.   Frontiers in Oncology

Obesity and insulin resistance: Pathophysiology and treatment

(2021) Yue Tong et al.   DRUG DISCOVERY TODAY

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding

(2020) Kwan Yi Chu et al.   Molecular Metabolism

Polydatin mitigates pancreatic β-cell damage through its antioxidant activity

(2020) Ahmed I. Yousef et al.   BIOMEDICINE & PHARMACOTHERAPY

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells

(2019) Jeff Ji et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

(2019) Yunxia Zhu et al.   Nutrition & Metabolism

Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice

(2019) Li Zheng et al.   Biomed Research International

Molecular imaging of β-cells: diabetes and beyond

(2018) Weijun Wei et al.   ADVANCED DRUG DELIVERY REVIEWS

Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells

(2018) Diti Chatterjee Bhowmick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

(2018) Soh Yamamoto et al.   Cell Reports

Autophagy in Adipose Tissue Physiology and Pathophysiology

(2018) Maroua Ferhat et al.   ANTIOXIDANTS & REDOX SIGNALING

Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes

(2018) Ziyu Song et al.   FASEB JOURNAL

Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress

(2017) Hongliang Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

(2017) Manuel Blandino-Rosano et al.   Nature Communications

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

(2016) Yu Wang et al.   Cardiovascular Diabetology

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression

(2015) Yanfei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells

(2014) Safia Costes et al.   Autophagy

Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats

(2014) QI ZHANG et al.   Molecular Medicine Reports

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autophagy as initiator or executioner of cell death

(2014) Elena A. Minina et al.   TRENDS IN PLANT SCIENCE

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking

(2012) Jannick Pétremand et al.   DIABETES

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE