SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

(2020) Youguang Gao et al.   Journal of Translational Medicine

Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis

(2020) Gang Luo et al.   TOXICOLOGY IN VITRO

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

(2020) Jing-Ying Lin et al.   Aging-US

CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis

(2020) Chunyang Lv et al.   BIOSCIENCE REPORTS

Particulate Matter Activates SIRT1‐SREBP1‐PIR Pathway to Promote Pulmonary Fibroblast Inflammation and Enhance Lung Fibrosis

(2020) Chia-Ping Tien et al.   FASEB JOURNAL

PACAP ameliorates fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation

(2020) Qiuxia Yan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway

(2020) Rui‑Xiong Huang et al.   Molecular Medicine Reports

Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development

(2020) Juvita D. Iljas et al.   AGING CELL

Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis

(2020) Mao Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF‐κB/NLRP3 inflammasome and sirtuin 1/autophagy axis

(2020) Shin‐Ruen Yang et al.   FASEB JOURNAL

Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling

(2020) Jiong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sirtuins as endogenous regulators of lung fibrosis: A current perspective

(2020) Somnath Mazumder et al.   LIFE SCIENCES

Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway

(2020) Yanping Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effects of polydatin against sulfur mustard-induced hepatic injury

(2019) Hao Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling

(2019) Tongzhou Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Polydatin protects against acute cholestatic liver injury in mice via the inhibition of oxidative stress and endoplasmic reticulum stress

(2019) Jinan Fang et al.   Journal of Functional Foods

Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD

(2019) Chia-Ping Tien et al.   Aging-US

Polydatin and I-CBP112 protects early bovine embryo against nicotinamide-induced mitochondrial dysfunction

(2019) Yu-Guo Yuan et al.   THERIOGENOLOGY

Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

(2019) Siqi Xu et al.   Frontiers in Physiology

Polydatin, Natural Precursor of Resveratrol, Promotes Osteogenic Differentiation of Mesenchymal Stem Cells

(2018) Adriana Di Benedetto et al.   International Journal of Medical Sciences

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

The protective mechanisms of polydatin in cerebral ischemia

(2018) Kim San Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK

(2018) Jing Wang et al.   OncoTargets and Therapy

Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes

(2017) Dong-Sheng He et al.   Molecular Medicine Reports

Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1)

(2017) Imran Khan et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway

(2017) Lvyi Chen et al.   Food & Function

Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation

(2017) Wenqi Meng et al.   Scientific Reports

SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway

(2016) Hong Yang et al.   ACTA PHARMACOLOGICA SINICA

MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ–dependent manner

(2016) Kai Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway

(2016) YI MA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

(2016) Da-ming Sui et al.   MEDIATORS OF INFLAMMATION

Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial DysfunctionviaSIRT1 Activation and p53 Deacetylation

(2016) Zhenhua Zeng et al.   Oxidative Medicine and Cellular Longevity

Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway

(2016) Lina Gu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resveratrol and Cardiovascular Diseases

(2016) Dominique Bonnefont-Rousselot   Nutrients

Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2pathway

(2015) Pengyun Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling

(2015) Xiaozhi Bai et al.   Scientific Reports

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human

(2013) Supriya R. Kulkarni et al.   ANTIOXIDANTS & REDOX SIGNALING

Phenolic composition and antioxidant activity in sparkling wines: Modulation by the ageing on lees

(2013) C.A. Stefenon et al.   FOOD CHEMISTRY

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Polydatin: A review of pharmacology and pharmacokinetics

(2013) Qiao-Hui Du et al.   PHARMACEUTICAL BIOLOGY

Comparision of Piceid and Resveratrol in Antioxidation and Antiproliferation Activities In Vitro

(2013) Dan Su et al.   PLoS One

Roles of p38 MAPKs in invasion and metastasis

(2012) Ivan del Barco Barrantes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain

(2011) Hui Ji et al.   BRAIN RESEARCH BULLETIN

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: Ménage à trois or ménage à quatre?

(2010) Alexey Shiryaev et al.   CELLULAR SIGNALLING

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE