GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

(2020) Ya-Fei Lu et al.   ONCOGENE

Colorectal cancer

(2019) Evelien Dekker et al.   LANCET

Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization

(2018) Wanhong Chen et al.   LIFE SCIENCES

Inhibition of miR-423-5p suppressed prostate cancer through targeting GRIM-19

(2018) Haili Lin et al.   GENE

Antitumor activity of iNGR-GRIM-19 in colorectal cancer

(2017) Li Pang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

GRIM-19 expression is a potent prognostic marker in colorectal cancer

(2015) Miao Hao et al.   HUMAN PATHOLOGY

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance

(2015) E. Martinez-Balibrea et al.   MOLECULAR CANCER THERAPEUTICS

Decreased expression of GRIM-19 by DNA hypermethylation promotes aerobic glycolysis and cell proliferation in head and neck squamous cell carcinoma

(2015) Xiao-Yun Zhang et al.   Oncotarget

Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas

(2013) Tao Zhou et al.   HUMAN PATHOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice

(2013) S. Kalakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation

(2012) Xianmin Bu et al.   GENE

Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line

(2010) Yi Huang et al.   EXPERIMENTAL CELL RESEARCH

Overexpression of GRIM-19 in Cancer Cells Suppresses STAT3-Mediated Signal Transduction and Cancer Growth

(2010) Takashi Okamoto et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth

(2008) L. Zhang et al.   CLINICAL CANCER RESEARCH

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE