Bioinformatic analysis of SIRT7 sequence and structure

Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer

(2022) Chen Zhang et al.   Frontiers in Cell and Developmental Biology

SIRT7 in the aging process

(2022) Francisco Alejandro Lagunas-Rangel   CELLULAR AND MOLECULAR LIFE SCIENCES

PredictProtein - Predicting Protein Structure and Function for 29 Years

(2021) Michael Bernhofer et al.   NUCLEIC ACIDS RESEARCH

SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

(2021) Ai Qing Yu et al.   Frontiers in Cell and Developmental Biology

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

(2020) Xiaolong Tang et al.   NUCLEIC ACIDS RESEARCH

SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

(2020) Nicolás G. Simonet et al.   Science Advances

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7

(2019) Wesley Wei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

(2019) Ming Tang et al.   Science Advances

Role of N-terminus in function and dynamics of sirtuin 7: an in silico study

(2019) Marta Hałasa et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Current role of mammalian sirtuins in DNA repair

(2019) Francisco Alejandro Lagunas-Rangel   DNA REPAIR

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

LC–MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes

(2018) Kana Tanabe et al.   Scientific Reports

Cyclic tripeptide-based potent human SIRT7 inhibitors

(2018) Shengchao Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7

(2018) Di Wu et al.   Frontiers in Endocrinology

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

(2017) Maximilian F. Blank et al.   NUCLEIC ACIDS RESEARCH

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

(2017) Xiaolong Tang et al.   Nature Communications

SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context

(2016) Zhen Tong et al.   ACS Chemical Biology

SIRT7 Is an RNA-Activated Protein Lysine Deacylase

(2016) Zhen Tong et al.   ACS Chemical Biology

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status

(2016) A Kurylowicz et al.   INTERNATIONAL JOURNAL OF OBESITY

Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture

(2016) Anu Priyanka et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response

(2015) Shashi Kiran et al.   EXPERIMENTAL CELL RESEARCH

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

(2013) Susan Costantini et al.   BMC EVOLUTIONARY BIOLOGY

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis

(2013) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

Sirtuins in stress response: guardians of the genome

(2013) L Bosch-Presegué et al.   ONCOGENE

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

(2012) Jeong Kyu Kim et al.   HEPATOLOGY

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

(2012) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Structural basis for sirtuin function: What we know and what we don't

(2009) Brandi D. Sanders et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction

(2009) Alex N Nguyen Ba et al.   BMC BIOINFORMATICS

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH