Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1

Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes

(2021) Che Bian et al.   ACTA DIABETOLOGICA

CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis

(2021) Jiang Liu et al.   INFLAMMATION RESEARCH

USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway

(2021) Fei Gao et al.   Journal of Inflammation-London

SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway

(2021) Che Bian et al.   LABORATORY INVESTIGATION

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

(2020) Ying Zhang et al.   Molecular Medicine Reports

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

(2020) Yong Yang et al.   Frontiers in Pharmacology

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

(2019) Mi Kyung Park et al.   Nature Communications

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy

(2019) Hirokazu Muraoka et al.   Cell Reports

Sirt6 attenuates hypoxia‐induced tubular epithelial cell injury via targeting G2/M phase arrest

(2019) Zhao Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of dapagliflozin, a sodium‐glucose co‐transporter‐2 inhibitor, on gluconeogenesis in proximal renal tubules

(2019) Jin Hee Kim et al.   DIABETES OBESITY & METABOLISM

FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake

(2019) Ling Li et al.   Journal of Translational Medicine

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice

(2018) Yingli Jia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition

(2016) Volker Vallon et al.   DIABETOLOGIA

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

(2016) Nunzia D’Onofrio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis

(2016) Gaurav Pandey et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

(2016) Ralph A. DeFronzo et al.   Nature Reviews Nephrology

The Mechanisms and Therapeutic Potential of SGLT2 Inhibitors in Diabetes Mellitus

(2015) Volker Vallon   Annual Review of Medicine

Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline

(2013) Paul E. Stevens   ANNALS OF INTERNAL MEDICINE

Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes

(2013) R. A. DeFronzo et al.   DIABETES CARE

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule

(2010) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

(2009) J. E. Gerich   DIABETIC MEDICINE

Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes

(2008) J. F. List et al.   DIABETES CARE