A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

(2019) Jiabing Wang et al.   Acta Pharmaceutica Sinica B

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

(2019) Zhilei Wang et al.   Acta Pharmaceutica Sinica B

Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury

(2019) Junke Song et al.   Acta Pharmaceutica Sinica B

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

(2019) Yuchun Zuo et al.   Journal of Neuroinflammation

Histone methyl transferases: A class of epigenetic opportunities to counter uncontrolled cell proliferation

(2019) Pankaj Kumar Singh   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function

(2019) Marjorie Brand et al.   Cell Stem Cell

Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies

(2019) Yi Zhu et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-neuroinflammatory Agents for Ischemic Stroke

(2019) Xu-Wen Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood–brain barrier integrity: a translational study

(2019) Luca Liberale et al.   EUROPEAN HEART JOURNAL

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting EZH2 with tazemetostat

(2018) Shinichi Makita et al.   LANCET ONCOLOGY

Histone Methyltransferase EZH2: A Therapeutic Target for Ovarian Cancer

(2018) Bayley A. Jones et al.   MOLECULAR CANCER THERAPEUTICS

Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression

(2018) Jian Liu et al.   ONCOGENE

Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells

(2018) Ewa Forma et al.   PLoS One

Epigenetic Modifications Associated to Neuroinflammation and Neuropathic Pain After Neural Trauma

(2018) Clara Penas et al.   Frontiers in Cellular Neuroscience

Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

(2018) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease

(2018) Shuyue Xia et al.   LIFE SCIENCES

Identification of a cellularly active SIRT6 allosteric activator

(2018) Zhimin Huang et al.   Nature Chemical Biology

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6

(2017) María A. Zorrilla-Zubilete et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

(2017) Wei Zhang et al.   NEUROSCIENCE

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

(2017) Connor Stonesifer et al.   PROGRESS IN NEUROBIOLOGY

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Neuroprotective Functions for the Histone Deacetylase SIRT6

(2017) Shai Kaluski et al.   Cell Reports

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation

(2016) Anees Fatima et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

(2016) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

(2016) Jiaxiang Shao et al.   Protein & Cell

Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells

(2016) Diandian Li et al.   Scientific Reports

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway

(2015) F. Yang et al.   NEUROSCIENCE

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

(2015) Junhu Wan et al.   NUCLEIC ACIDS RESEARCH

Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression

(2015) Yuan Shen et al.   TRENDS IN PLANT SCIENCE

Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease

(2014) Curtis R. French et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients

(2014) Y A Ito et al.   Cell Death & Disease

Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

(2013) Ok-Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

SIRT6 exhibits nucleosome-dependent deacetylase activity

(2013) R. Gil et al.   NUCLEIC ACIDS RESEARCH

Acute Cerebrovascular Disease in the Young

(2013) Arndt Rolfs et al.   STROKE

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

(2012) Francesco Crea et al.   CANCER AND METASTASIS REVIEWS

FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells

(2011) Juan Du et al.   BREAST CANCER RESEARCH AND TREATMENT

FOXC1 Is a Potential Prognostic Biomarker with Functional Significance in Basal-like Breast Cancer

(2010) P. S. Ray et al.   CANCER RESEARCH

Forkhead transcription factors in chronic inflammation

(2009) Stanford L. Peng   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY