Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

(2021) Yashira L. Negrón Abril et al.   ONCOGENE

The growing landscape of succinylation links metabolism and heart disease

(2021) Lanting Yang et al.   Epigenomics

Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery

(2020) Ling-Ling Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations

(2020) Carina Glas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

(2019) Kai Su Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells

(2018) Ling-Ling Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent and Selective Inhibitors of Human Sirtuin 5

(2018) Diana Kalbas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

(2017) Martin Pannek et al.   Nature Communications

SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2

(2016) Fengling Li et al.   Frontiers in Cellular Neuroscience

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

(2015) Erik D. Guetschow et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer

(2015) Surinder Kumar et al.   ANTIOXIDANTS & REDOX SIGNALING

The chemical biology of sirtuins

(2015) Bing Chen et al.   CHEMICAL SOCIETY REVIEWS

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases

(2015) Claudia Roessler et al.   JOURNAL OF MEDICINAL CHEMISTRY

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

(2014) Claudia Roessler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

(2012) Benjamin Suenkel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5

(2012) Bruce G. Szczepankiewicz et al.   JOURNAL OF ORGANIC CHEMISTRY

Thiosuccinyl Peptides as Sirt5-Specific Inhibitors

(2012) Bin He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibitors of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5

(2012) Benjamin Maurer et al.   ACS Medicinal Chemistry Letters

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE