Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury

(2019) Ahmed A Mohsin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of post‐translational modifications in cardiac hypertrophy

(2019) Kaowen Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1

(2019) Rajaa Sebaa et al.   Molecular Metabolism

Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress

(2019) Didier Morin et al.   FREE RADICAL BIOLOGY AND MEDICINE

CIRP downregulation renders cardiac cells prone to apoptosis in heart failure

(2019) Minxiao Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Organization of Mitochondrial Supercomplexes is Modulated by Oxidative Stress In Vivo in Mouse Models of Mitochondrial Encephalopathy

(2018) Mir Anwar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Programmed necrosis in heart disease: Molecular mechanisms and clinical implications

(2018) Hong Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin

(2018) Jung Hyun Park et al.   Scientific Reports

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

(2018) Georges N. Kanaan et al.   Redox Biology

Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria

(2018) Julia Chalker et al.   Redox Biology

Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

(2018) Rebecca M. Parodi-Rullán et al.   Frontiers in Physiology

Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria

(2018) Sehwan Jang et al.   Scientific Reports

Impact of Oxidative Stress on the Heart and Vasculature

(2017) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure

(2016) Freya L. Sheeran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure

(2016) Arata Fukushima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Post-translational modifications in mitochondria: protein signaling in the powerhouse

(2016) Amanda R. Stram et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

O-GlcNAcomic Profiling Identifies WidespreadO-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

(2015) Junfeng Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

(2014) George A. Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Post-translational modification of mitochondria as a novel mode of regulation

(2014) Annette Hofer et al.   EXPERIMENTAL GERONTOLOGY

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset of Age-dependent Cataracts in Mice

(2014) Hongli Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions

(2014) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling by S-nitrosylation in the heart

(2014) Elizabeth Murphy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutaredoxin 2 Reduces Both Thioredoxin 2 and Thioredoxin 1 and Protects Cells from Apoptosis Induced by Auranofin and 4-Hydroxynonenal

(2013) Huihui Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Glutaredoxin-2 Is Required to Control Proton Leak through Uncoupling Protein-3

(2013) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Aging-dependent changes in rat heart mitochondrial glutaredoxins—Implications for redox regulation

(2013) Xing-Huang Gao et al.   Redox Biology

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Redox Regulation of Mitochondrial ATP Synthase

(2011) Sheng-Bing Wang et al.   CIRCULATION RESEARCH

Phosphoproteome Analysis Reveals Regulatory Sites in Major Pathways of Cardiac Mitochondria

(2010) Ning Deng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Pattern of Human Glutaredoxin 2 Isoforms: Identification and Characterization of Two Testis/Cancer Cell-Specific Isoforms

(2007) Maria Elisabet Lönn et al.   ANTIOXIDANTS & REDOX SIGNALING