Advances in the Synthesis and Bio-Applications of Pyrazine Derivatives: A Review

Additive-Assisted Optimization in Morphology and Optoelectronic Properties of Inorganic Mixed Sn-Pb Halide Perovskites

(2022) Rubaiya Murshed et al.   Materials

Review on Synthesis, Reactions and Biological Properties of Seven Member Heterocyclic Compounds: Azepine, Azepane, Azepinone

(2021) Manvinder Kaur et al.   CURRENT ORGANIC CHEMISTRY

Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of α,β-Unsaturated Ketones

(2021) Sixiu Liu et al.   ORGANIC LETTERS

DFT study of low-energy electron interaction with pyridine, pyrazine and their halo derivatives

(2021) Natalia Tańska   EUROPEAN PHYSICAL JOURNAL D

Subcritical water extraction as a circular economy approach to recover energy and agrochemicals from sewage sludge

(2021) Matat Zohar et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Synthesis and Characterization of a Novel Heterocyclic Schiff Base and Development of a Fluorescent Sensor for Vitamin B12

(2021) Savitha Devaswamparambil Pradeep et al.   JOURNAL OF FLUORESCENCE

Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity

(2021) Valentina Albanese et al.   JOURNAL OF MEDICINAL CHEMISTRY

2,2′-(Arylmethylene)bis(3-hydroxy-5,5-dimethylcyclohex-2-enone) crystals formation via atom economy reaction and their antioxidant activity

(2021) Deepa Thakur et al.   MONATSHEFTE FUR CHEMIE

Current status of quinoxaline and quinoxaline 1,4‐di‐ N ‐oxides derivatives as potential antiparasitic agents

(2021) Jacqueline Soto‐Sánchez et al.   Chemical Biology & Drug Design

Potential application of lactic acid bacteria in the biopreservation of red grape from mycotoxigenic fungi

(2021) Victor Dopazo et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides

(2021) Jiri Kos et al.   MOLECULES

Heterocyclic Aromatic Amines in Meat: Formation, Isolation, Risk Assessment, and Inhibitory Effect of Plant Extracts

(2021) Hafiz Rehan Nadeem et al.   Foods

B ← N Coordination Enables Efficient p-Doping in a Pyrazine-Based Polymer Donor Toward Enhanced Photovoltaic Performance

(2021) Liang Guo et al.   MACROMOLECULES

Synthesis of 2-arylideneimidazo[1,2-a]pyrazine-3,6,8(2H,5H,7H)-triones as a result of oxidation of 4-arylidene-2-methyl-1H-imidazol-5(4H)-ones with selenium dioxide

(2020) Elvira R. Zaitseva et al.   Chemistry of Heterocyclic Compounds

Synthesis of Novel 1-(1,5-Diaryl-1,10b-Dihydropyrrolo- [1,2-A][1,2,4]Triazolo[3,4-C]Pyrazin-3-Yl)Ethanones Via 1,3-Dipolar Cycloaddition of Nitrilimine

(2020) Yulin Huang et al.   Chemistry of Heterocyclic Compounds

An efficient synthesis of spiroacridinone derivatives from the facile reaction of isatins, dimedone, and 5‐aminoindazole (6‐aminoindazole or 5‐aminoindole)

(2020) Wen‐Ting Zhang et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Molecular Interactions of Pyrazine-Based Compounds to Proteins

(2020) Martin Juhás et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Substituted 6,7-Dihydro-5H-pyrrolo[2,3-c]pyridazines/pyrazines via Catalyst-Free Tandem Hydroamination–Aromatic Substitution

(2020) Jeremy A. Turkett et al.   JOURNAL OF ORGANIC CHEMISTRY

A panchromatic pyrazine-fused porphyrin dimer

(2020) Inna A. Abdulaeva et al.   MENDELEEV COMMUNICATIONS

A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

(2020) Nagaraju Kerru et al.   MOLECULES

From Acylethynylpyrroles to Pyrrolo[1,2-a]pyrazines in One Step

(2020) E. F. Sagitova et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Metal‐Free Oxidative [5+1] Cyclization of 1,5‐Enynes for the Synthesis of Pyrazine 1‐Oxide

(2020) Xiao‐Feng Xia et al.   ADVANCED SYNTHESIS & CATALYSIS

Pyrazines: Synthesis and Industrial Application of these Valuable Flavor and Fragrance Compounds

(2020) Frederik B. Mortzfeld et al.   Biotechnology Journal

Design, Synthesis and Opto-electrochemical Properties of Novel Donor–Acceptor Based 2,3-Di(hetero-2-yl)pyrido[2,3-b]pyrazine Amine Derivatives as Blue-Orange Fluorescent Materials

(2020) Suraj S. Mahadik et al.   DYES AND PIGMENTS

Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1‐a]isoquinolines derivatives

(2020) Seyyed Ali Moghaddas et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Biobased Pyrazine-Containing Polyesters

(2020) Martien A. Würdemann et al.   ACS Sustainable Chemistry & Engineering

Pyrazine-EDOT D-A-D type Hybrid Polymer for Patterned Flexible Electrochromic Devices

(2020) Faqi Hu et al.   ELECTROCHIMICA ACTA

A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents

(2020) Remon M. Zaki et al.   MEDICINAL CHEMISTRY RESEARCH

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

Spectroscopic studies, density functional theory calculations, non-linear optical properties, biological activity of 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid and its chelates with Nickel (II), Copper (II), Zinc (II) and Palladium (II) metal ions

(2020) Nora S. Abdel-Kader et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, photophysical and nonlinear optical properties of [1,2,5]oxadiazolo[3,4-b]pyrazine-based linear push-pull systems

(2020) Egor V. Verbitskiy et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents

(2020) Afzal B. Shaik et al.   Arabian Journal of Chemistry

Carboxylate substituted pyrazine: A simple and low-cost building block for novel wide bandgap polymer donor enables 15.3% efficiency in organic solar cells

(2020) Jingnan Wu et al.   Nano Energy

Discovery of a Potent Tyrosine Kinase AXL Inhibitor Bearing the 3-((2,3,4,5-Tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine Core

(2019) Yueliang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, crystal structure, insecticidal activities, molecular docking and QSAR studies of some new phospho guanidines and phospho pyrazines as cholinesterase inhibitors

(2019) Khodayar Gholivand et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study

(2019) Morteza Shiri et al.   Journal of the Iranian Chemical Society

A Facile Synthesis of Substituted 2‐(5‐(Benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities

(2019) Sanjeev R. Patil et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Pyrrolo[1,2-a]pyrazine Derivatives

(2019) Jinwoo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functional π-Conjugated Two-Dimensional Covalent Organic Frameworks

(2019) H. Vignesh Babu et al.   ACS Applied Materials & Interfaces

Design, synthesis and biological evaluation of imidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD9 inhibitors

(2019) Peiyuan Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-one derivatives

(2019) Svitlana S. Kovalenko et al.   Chemistry of Heterocyclic Compounds

In Search of Bioactivity – Phyllobilins, an Unexplored Class of Abundant Heterocyclic Plant Metabolites from Breakdown of Chlorophyll

(2019) Simone Moser et al.   ISRAEL JOURNAL OF CHEMISTRY

Synthesis and characterization of new asymmetric thieno[3,4-b]pyrazine-based D−π−A−A type small molecular donors with near-infrared absorption and their photovoltaic applications

(2019) Shu-Hua Chou et al.   ORGANIC ELECTRONICS

Tandem Pd-Catalyzed Intermolecular Allylic Alkylation/Allylic Dearomatization Reaction of Benzoylmethyl pyridines, Pyrazines, and Quinolines

(2019) Hui-Jun Zhang et al.   ORGANIC LETTERS

Pyrazine-2-carbohydrazone of Pyridoxal 5′-Phosphate: Synthesis, Stability, Formation Kinetics, and Interaction with DNA

(2019) G. A. Gamov et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Synthesis, properties and application of novel 5,6,5,6-tetracyclic pyrazine/pyrrole-fused unsymmetric bis(BF2) fluorescent dyes: BOPYPYs

(2019) Xindong Jiang et al.   CHINESE CHEMICAL LETTERS

Metal–organic frameworks with multicomponents in order

(2019) Qingqing Pang et al.   COORDINATION CHEMISTRY REVIEWS

Substantiation to structure-property of pyrazine-based compounds by undeniable impress of its different connectivities

(2019) Maryam Bazargan et al.   JOURNAL OF MOLECULAR STRUCTURE

Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles

(2019) M. Klika Škopić et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Use of Pyrimidine and Pyrazine Bridges as a Design Strategy To Improve the Performance of Thermally Activated Delayed Fluorescence Organic Light Emitting Diodes

(2019) Paloma Lays dos Santos et al.   ACS Applied Materials & Interfaces

A Pyrazine-Based Polymer for Fast-Charge Batteries

(2019) Minglei Mao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring

(2019) Nazar M. Tsizorik et al.   Chemistry of Heterocyclic Compounds

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling

(2019) Yevhenii V. Hrynyshyn et al.   Chemistry of Heterocyclic Compounds

Synthesis and properties of liquid pyrazine dyes

(2019) Jae-Young Lee et al.   DYES AND PIGMENTS

Effective synthesis of benzimidazoles-imidazo[1,2-a]pyrazine conjugates: A comparative study of mono-and bis-benzimidazoles for antitumor activity

(2019) Iqubal Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The bioisosteric modification of pyrazinamide derivatives led to potent antitubercular agents: Synthesis via click approach and molecular docking of pyrazine-1,2,3-triazoles

(2019) Rajkumar Reddyrajula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells

(2019) Yohan Seo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of vinazene end capped dipyrrolo[2,3-b:2′,3′-e]pyrazine-2,6(1H,5H)-dione small molecules as non-fullerene acceptors for bulk heterojunction organic solar cells

(2019) Gangala Sivakumar et al.   MATERIALS CHEMISTRY AND PHYSICS

Controllable luminescent behaviors with pyrazine and benzimidazole groups: Syntheses, crystal structures and properties

(2019) Yong-Tao Wang et al.   OPTICAL MATERIALS

Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases

(2018) Lakshmaiah Gingipalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological evaluation, and metabolic stability of phenazine derivatives as antibacterial agents

(2018) Maddeboina Krishnaiah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles

(2018) Mokhtar A. Abd ul-Malik et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of a polymer-capped palladium nanoparticles and its application as a reusable catalyst in oxidative coupling reaction of α-hydroxyketones and 1,2-diamines for preparation of pyrazines and quinoxalines

(2018) Mohammad Ali Karimi Zarchi et al.   Journal of the Iranian Chemical Society

Formation of spirocyclic indenopyrazine–pyridooxazines via 1,4-dipolar cycloaddition reaction

(2018) Hosna Sayadian et al.   MONATSHEFTE FUR CHEMIE

Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

(2018) T. N. V. Ganesh Kumar et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Synthesis of Angular [1,2,5]Oxadiazolo[3,4-b]pyrazino-[1′,2′ : 1,2]pyrrolo[2,3-e][1,4]diazepine by Stepwise Reaction of Pyrrolo[1,2-a]pyrazinetrione with 3,4-Diaminofurazan

(2018) A. V. Chervyakov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Structure of a New Semisynthetic Taraxerone Derivative Fused to a Pyrazine Ring through the C2–C3 Bond

(2018) A. D. Zorina et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 8a-Chlorotetrahydropyrrolo[1,2-H]pyrazine-1,6,7-(2H)-triones from 3-Methylidenepiperazin-2-ones and Oxalyl Chloride

(2018) А. V. Chervyakov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of novel 1,2-dihydropyrrolo[1,2- a ]pyrazin-1(2 H )-one derivatives

(2018) Iryna O. Yaremchuk et al.   TETRAHEDRON LETTERS

Efficient Access to Imidazo[1,2-a]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent

(2018) R. Nishanth Rao et al.   ACS Combinatorial Science

Sustainable Routes for the Synthesis of Renewable Heteroatom-Containing Chemicals

(2018) Max J. Hülsey et al.   ACS Sustainable Chemistry & Engineering

Synthesis of 2-Acyl-Substituted Pyrazine Derivatives through Silver-Catalyzed Decarboxylative Coupling Reactions

(2018) Yuan Li et al.   ChemistrySelect

Synthesis, annulation, and heterofunctionalization of 4-hydrazinylpyrazolo[1,5-а]pyrazines

(2018) Nazar M. Tsizorik et al.   Chemistry of Heterocyclic Compounds

Investigation of Photophysical Properties on Carbazole and Pyrazine Based Conjugated Polymer: Excellent Fluorescence Sensing Towards to Cadmium Ion

(2018) Anjali Upadhyay et al.   POLYMER SCIENCE SERIES A

9-Ethyl-3-{6-(het)aryl-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl}-9H-carbazoles: synthesis and study of sensitivity to nitroaromatic compounds

(2018) E. V. Verbitskiy et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis of Spiro[indole-3,2′-pyrroles] from Pyrrolopyrazinetriones and Aminocyclohexenones

(2018) A. V. Chervyakov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics

(2018) Shufeng Yan et al.   Journal of Materials Chemistry B

Heteropore covalent organic frameworks: a new class of porous organic polymers with well-ordered hierarchical porosities

(2018) Rong-Ran Liang et al.   Organic Chemistry Frontiers

Tracking the Process of a Solvothermal Domino Reaction Leading to a Stable Triheteroarylmethyl Radical: A Combined Crystallographic and Mass-Spectrometric Study

(2018) Bin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium Nanoparticles Encapsulated in the MIL-101-Catalyzed One-Pot Reaction of Alcohol Oxidation and Aldimine Condensation

(2018) Yu-Yang Zhang et al.   INORGANIC CHEMISTRY

Pyrazine derivatives as green oil field corrosion inhibitors for steel

(2018) I.B. Obot et al.   JOURNAL OF MOLECULAR LIQUIDS

Therapeutic potential of pteridine derivatives: A comprehensive review

(2018) Violeta Carmona-Martínez et al.   MEDICINAL RESEARCH REVIEWS

Synthesis of 3-Benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

(2018) V. A. Gaidukevich et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Selective synthesis of oxazoles and pyrazines from α-bromo-1-phenylethanone using a by-product-promoted strategy

(2018) Changhui Liu et al.   TETRAHEDRON

Self-assembled nematic colloidal motors powered by light

(2018) Ye Yuan et al.   Nature Communications

Synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives via Hantzsch reaction using nicotinic acid as a green and reusable catalyst

(2018) Jamal Davarpanah et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, characterization and optoelectronic properties of pyrrolopyrazine based Y-shaped color-tunable dipolar molecules

(2018) Puttavva Meti et al.   DYES AND PIGMENTS

Design and synthesis of novel 7-aminosubstituted pyrido[2,3- b ]pyrazines exhibiting anti-breast cancer activity

(2017) Orestis Argyros et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 1,3,4-thiadiazole compounds including pyrazine moiety: Synthesis, structural properties and antimicrobial features

(2017) Mahmut Gür et al.   JOURNAL OF MOLECULAR STRUCTURE

Phosphine Supported Ruthenium Nanoparticle Catalyzed Synthesis of Substituted Pyrazines and Imidazoles from α-Diketones

(2017) Prasad Ganji et al.   JOURNAL OF ORGANIC CHEMISTRY

A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines

(2017) Peter J. Lindsay-Scott et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of novel nanostructured dinitropyrazine molten salt catalyst for the synthesis of sulfanylpyridines via anomeric based oxidation

(2017) Mohammad Ali Zolfigol et al.   Journal of the Iranian Chemical Society

One-pot synthesis of novel 1-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives via an Ugi-azide 4CR process

(2017) Mehdi Ghandi et al.   MOLECULAR DIVERSITY

Synthesis of fluoroquinoxalin-2(1H)-one derivatives containing substituents in the pyrazine and benzene fragments

(2017) Yu. A. Azev et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Side-chain fluorination on the pyrido[3,4-b]pyrazine unit towards efficient photovoltaic polymers

(2017) Tao Wang et al.   Science China-Chemistry

Efficient synthesis of pyrazine boronic esters via palladium-catalyzed Miyaura borylation

(2017) Hongtao Lu et al.   TETRAHEDRON LETTERS

The first stable examples of compounds containing both diazonium and acyl azide, and synthesis of a new pyrazino[2′,3′:3,4]pyrazolo[5,1- c ][1,2,4]triazin-4(6 H )-one heterocyclic system

(2017) Sergey M. Ivanov et al.   TETRAHEDRON LETTERS

Design and synthesis of 5-methylpyrazine-2-carbohydrazide derivatives: A new anti-tubercular scaffold

(2017) P.B. Miniyar et al.   Arabian Journal of Chemistry

Recent advances in post-synthetic modification of metal–organic frameworks: New types and tandem reactions

(2017) Zheng Yin et al.   COORDINATION CHEMISTRY REVIEWS

Molecular design, synthesis and anticoagulant activity evaluation of fluorinated dabigatran analogues

(2016) Fei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Total synthesis and cytotoxic activities of longamide B, longamide B methyl ester, hanishin, and their analogues

(2016) Deng-Gao Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and docking studies of pyrazine–thiazolidinone hybrid scaffold targeting dormant tuberculosis

(2016) T.S. Chitre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines

(2016) Khyatiben V. Pathak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and Medicinal Applications of Benzimidazoles: An Overview

(2016) Sreerama Rajasekhar et al.   CURRENT ORGANIC SYNTHESIS

Studying the interaction between three synthesized heterocyclic sulfonamide compounds with hemoglobin by spectroscopy and molecular modeling techniques

(2016) Samane Naeeminejad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis of pyrazine via chemoselective reduction of β-keto-α-oximino ester using baker’s yeast

(2016) Kilwoong Mo et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Synthesis of Perylene Imide Diones as Platforms for the Development of Pyrazine Based Organic Semiconductors

(2016) Paula de Echegaray et al.   JOURNAL OF ORGANIC CHEMISTRY

Switchable Synthesis of Pyrroles and Pyrazines via Rh(II)-Catalyzed Reaction of 1,2,3-Triazoles with Isoxazoles: Experimental and DFT Evidence for the 1,4-Diazahexatriene Intermediate

(2016) Nikolai V. Rostovskii et al.   JOURNAL OF ORGANIC CHEMISTRY

Ionic liquid functionalized cellulose as an efficient heterogeneous catalyst for the facile and green synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media

(2016) Sevil Vaghefi Moghaddam et al.   Journal of the Iranian Chemical Society

Design, synthesis, and cytostatic activity of novel pyrazine sorafenib analogs

(2016) Zrinka Rajić Džolić et al.   MEDICINAL CHEMISTRY RESEARCH

Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and $$\alpha $$ α -aminoxylated 1,3-dicarbonyl compounds

(2016) Jianwei Yan et al.   MOLECULAR DIVERSITY

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Synthesis of polyfunctionalized pyrido[1,2-a]pyrazines and pyrazino[1,2-a]quinolines via one-pot multicomponent reactions

(2016) Renata I. Eften’eva et al.   MONATSHEFTE FUR CHEMIE

Small heterocycles as highly luminescent building blocks in the solid state for organic synthesis

(2016) Fabiano da Silveira Santos et al.   NEW JOURNAL OF CHEMISTRY

Molecular diversity in cyclization of Ugi-products leading to the synthesis of 2,5-diketopiperazines: computational study

(2016) Vahideh Zadsirjan et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Synthesis and conformational study of novel pyrazine-based pseudopeptides bearing amidoxime, amidoxime ester and 1,2,4-oxadiazole units

(2016) Olga V. Ovdiichuk et al.   TETRAHEDRON

Facile synthesis of hexahydropyrazino[2,3-e]pyrazines from 3-aminomethyl-1,2,4-triazoles

(2016) Dmytro M. Khomenko et al.   TETRAHEDRON LETTERS

Natural Therapies for Cardiovascular Diseases

(2016) Xiaochen Yang et al.   Biomed Research International

Covalent organic frameworks: a materials platform for structural and functional designs

(2016) Ning Huang et al.   Nature Reviews Materials

Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides

(2015) Jan Zitko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2- a ]pyrazine-3-carboxamides

(2015) G.V. Mokrov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, antimycobacterial and antifungal evaluation of some new 1-ethyl-5-(hetero)aryl-6-styryl-1,6-dihydropyrazine-2,3-dicarbonitriles

(2015) Egor V. Verbitskiy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazine- and pyridine-substituted prop-2-yn-1-ols, but-3-yn-2-ols, and but-3-yn-2-ones – purification, stability, and handling revised

(2015) Claudia Schindler et al.   Chemistry of Heterocyclic Compounds

Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations

(2015) Eloi P. Coutant et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Review of Pharmacokinetic Drug–Drug Interactions with the Anthelmintic Medications Albendazole and Mebendazole

(2015) Shane Ashley Pawluk et al.   CLINICAL PHARMACOKINETICS

Structure-Based Discovery of PDEs Inhibitors

(2015) Li Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines

(2015) Pascal Marchand et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

[1,2,5]Selenadiazolo[3,4-b]pyrazines: Synthesis from 3,4-Diamino-1,2,5-selena­diazole and Generation of Persistent Radical Anions

(2015) Lidia S. Konstantinova et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design of Pyrazolo-pyrrolo-pyrazines and Pyrazolo-pyrrolo-diazepines via AuCl3-Catalyzed and NaH-Supported Cyclization of N-Propargyl Pyrazoles

(2015) Sinan Basceken et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions

(2015) Monika Gaba et al.   MEDICINAL CHEMISTRY RESEARCH

Biologically Active Benzimidazole Derivatives

(2015) Subramaniyan Arulmurugan et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Synthesis of Unsymmetrical Pyrazines Based on α-Diazo Oxime Ethers

(2015) Nicole S. Y. Loy et al.   ORGANIC LETTERS

Endophytes-assisted biocontrol: novel insights in ecology and the mode of action of Paenibacillus

(2015) Daria Rybakova et al.   PLANT AND SOIL

Synthesis of quinoxalines and pyrido[2,3-b]pyrazines by Suzuki–Miyaura cross-coupling reaction

(2015) Arjun Kumbhar et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Synthesis of 8-aroylpyrrolo[1,2-a]pyrazine-1,6,7(2H)-triones and their reaction with water. New analogs of cyclic dipeptides

(2015) A. V. Chervyakov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Efficient Synthesis of (–)-Hanishin, (–)-Longamide B, and (–)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

(2015) Koichi Fukase et al.   SYNLETT

Synthesis of tetraaryl- and tetraalkenylpyrazines by Suzuki–Miyaura reactions of tetrachloropyrazine

(2015) Andranik Petrosyan et al.   TETRAHEDRON

Nature loves nitrogen heterocycles

(2015) Christopher T. Walsh   TETRAHEDRON LETTERS

Facile one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazines via oxidative cyclisation using chloramine T

(2015) Sanjib Mal et al.   TETRAHEDRON LETTERS

Nanosize Gold Promoted Vanadium Oxide Catalysts for Ammoxidation of 2-Methylpyrazine to 2-Cyanopyrazine

(2015) A. Alshammari et al.   TOPICS IN CATALYSIS

Nano Brönsted solid acid containing double-charged diazoniabi-cyclo[2.2.2]octane chloride supported on nano rice husk silica: an efficient catalyst for the one-pot synthesis of phthalazine compounds

(2015) Jamal Davarpanah et al.   RSC Advances

Synthesis and Evaluation of F-18 Labeled Pyrido[3,2-B]pyrazine Derivative as a Potential Imaging Agent for Non-Small-Cell Lung Cancer

(2015) Jeong Hoon Park et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

(2015) Pankaj Miniyar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

(2014) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Diastaphenazine, a new dimeric phenazine from an endophytic Streptomyces diastaticus subsp. ardesiacus

(2014) Yiqing Li et al.   JOURNAL OF ANTIBIOTICS

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Saturated N-Heterocycles

(2014) Cam-Van T. Vo et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly selective base-catalyzed ring closing Ugi-adducts from the reaction of 2-formylindole, 2-bromoacetic acid, amines and isocyanides

(2014) Morteza Shiri et al.   Journal of the Iranian Chemical Society

Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases

(2013) Francesco Casuscelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polymorphism of Dehydro-Aripiprazole, the Active Metabolite of the Antipsychotic Drug Aripiprazole (Abilify)

(2013) Tarek A. Zeidan et al.   CRYSTAL GROWTH & DESIGN

A simple synthesis of salicylamide and 2,5-diphenylpyrazine

(2013) Luo Mei et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Palau’amine and Related Oroidin Alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome

(2012) Theresa A. Lansdell et al.   JOURNAL OF NATURAL PRODUCTS

Phase Behavior and Conductivity of Sulfonated Block Copolymers Containing Heterocyclic Diazole-Based Ionic Liquids

(2012) Onnuri Kim et al.   MACROMOLECULES

Evaluation of Antioxidant and Immunity Function of Tetramethylpyrazine Phosphate Tablets in Vivo

(2012) Ling Guo et al.   MOLECULES

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

(2011) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?

(2011) Hayden Matthews et al.   INTERNATIONAL JOURNAL OF CANCER

3-TrifluoromethylquinoxalineN,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruziAgents and Mechanism of Action Studies

(2011) Diego Benitez et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel sulfonic acid functionalized ionic liquid catalyzed multicomponent synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives in water

(2011) Zhiwei Chen et al.   TETRAHEDRON LETTERS

Pyrazine Biosynthesis in Corynebacterium glutamicum

(2010) Jeroen S. Dickschat et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Alkylpyrazines: alarm pheromone components of the little fire ant, Wasmannia auropunctata (Roger) (Hymenoptera, Formicidae)

(2010) D. N. Showalter et al.   INSECTES SOCIAUX

Heterocycles in organic synthesis: thiazoles and triazoles as exemplar cases of synthetic auxiliaries

(2010) Alessandro Dondoni   ORGANIC & BIOMOLECULAR CHEMISTRY

The Evaluation of Some Heterocycles as Antioxidant Additives for Lubricating Oils

(2010) O. M. O. Habib et al.   PETROLEUM SCIENCE AND TECHNOLOGY

From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges

(2009) Triana Hertiani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alternating Copolymerizations Using a Grubbs-Type Initiator with an Unsymmetrical, Chiral N-Heterocyclic Carbene Ligand

(2008) Kati Vehlow et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-pot, three-component route to 2H-indazolo[2,1-b]phthalazine-triones

(2008) Maryam Sayyafi et al.   TETRAHEDRON