期刊
ORGANIC LETTERS
卷 21, 期 9, 页码 3314-3318出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01060
关键词
-
资金
- National Key R&D Program of China [2016YFA0202900]
- NSFC [21821002, 21572252]
An efficient synthesis of nitrogen-containing heterocycles via Pd-catalyzed tandem allylic alkylation and dearomatization reactions was reported. In this reaction design, heteroarenes such as pyridines, pyrazines, and quinolines serve as bis-nucleophiles by installing a benzoyl group at the C2 benzylic position. With but-2-ene-1,4-diyl dimethyl dicarbonate as the bis-electrophile, the tandem Pd-catalyzed intermolecular allylic alkylation/allylic dearomatization reaction of benzoylmethylsubstituted heteroarenes has been developed. 2,3-Dihydroindolizine, 6,7-dihydropyrrolo[1,2-c]pyrazine, and 1,2-dihydropyrrolo[1,2-a]quinolin derivatives were obtained in moderate to good yields.
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