Article
Chemistry, Multidisciplinary
Rajavenkatesh Krishnamoorthy, Parthiban Anaikutti
Summary: An efficient iodine-catalyzed method for synthesizing imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyridines via one-pot three-component condensations has been reported. The photophysical properties of these new fluorescent derivatives are also presented. The synthesized compounds were evaluated for their anti-cancer activities and one compound showed promising results.
Article
Biochemistry & Molecular Biology
Bulian Deng, Zhiqiang Sun, Yuxi Wang, Ruiyao Mai, Zichao Yang, Yichang Ren, Jin Liu, Junli Huang, Zeli Ma, Ting Chen, Canjun Zeng, Jianjun Chen
Summary: This study designed a series of novel imidazo[1,2-a]pyrazine derivatives as potential tubulin inhibitors through structural optimization and ring fusion strategy. Among them, compound TB-25 exhibited the strongest inhibitory effects against HCT-116 cells. It could effectively inhibit tubulin polymerization and destroy the dynamic equilibrium of microtubules in cells, induce G2/M phase cell cycle arrest and apoptosis, and suppress cell migration.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chuchu Li, Yuqiao Han, Zhengyang Wang, Yanan Yu, Chen Wang, Ziwei Ren, Yanzhi Guo, Tong Zhu, XuWen Li, Suzhen Dong, Mingliang Ma
Summary: Compound 42 showed excellent dual PI3K/mTOR inhibitory activity, significant in vitro and in vivo anti-tumoral activities, good kinase selectivity, low hepatotoxicity, modest plasma clearance and acceptable oral bioavailability. It is a promising PI3K/mTOR targeted anti-cancer drug candidate.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bineeth Baral, Juhi Dutta, Umakanta Subudhi
Summary: Branched DNA (bDNA) nanostructures interact with circulating protein BSA and cellular enzyme BLC through hydrogen bonding and van der Waals interaction. The negative free energy observed in ITC indicates a spontaneous reaction for BLC-bDNA interaction, and the presence of bDNA does not affect the structural stability and secondary conformation of proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Raghu Solanki, Hadis Rostamabadi, Sunita Patel, Seid Mahdi Jafari
Summary: Bovine serum albumin nanoparticles (BSA NPs) are promising for efficient anti-cancer drug delivery due to their non-toxicity, non-immunogenicity, biodegradability, biocompatibility, and high drug-binding capacity. Understanding the structural/physicochemical features of BSA molecule and its derived nanovehicles, as well as effective variables in delivery mechanism, is essential for leveraging the potential of this carrier in cancer therapy. The review highlights recent advances in using BSA NPs for delivering anti-cancer agents and discusses the factors influencing the efficiency of therapeutics in nano-delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Kaushik Kuche, Vivek Yadav, M. Dharshini, Rohan Ghadi, Dasharath Chaudhari, Tushar Date, Sanyog Jain
Summary: This study investigates the synergistic effect of sorafenib and simvastatin in triggering ferroptosis for cancer therapy. The researchers developed bovine serum albumin nanoparticles loaded with both drugs and observed a significant reduction in tumor volume in in-vivo experiments. The study highlights the potential of this drug delivery system for inducing ferroptosis and improving therapeutic efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Agonist Kastrati, Alexander Kremsmair, Alisa S. Sunagatullina, Vasilii Korotenko, Yusuf C. Guersoy, Saroj K. Rout, Fabio Lima, Cara E. Brocklehurst, Konstantin Karaghiosoff, Hendrik Zipse, Paul Knochel
Summary: Straightforward calculations have led to the development of a set of organometallic reactions for the regioselective functionalization of the underexplored fused N-heterocycle imidazo[1,2-a]pyrazine. These reactions provide a way to access polyfunctionalized imidazopyrazine heterocycles.
Article
Chemistry, Applied
Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang
Summary: This study investigates the binding of six flavonoids with BSA containing Cu2+ using UV-vis, fluorescence, and molecular docking. The results show that the complexation of Cu2+ significantly affects the binding of flavonoids with BSA.
Article
Biochemistry & Molecular Biology
Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Hamad A. Al-Lohedan, M. Abul Farah, Osama Ibrahim Alsowilem
Summary: This study investigates the binding mechanism of the anticancer drug gemcitabine with the plasma protein BSA using various experimental and computational methods. The formation of a complex between gemcitabine and BSA was confirmed, with the involvement of tyrosine residues in fluorescence quenching highlighted. The primary binding site of gemcitabine in BSA was identified as drug binding site 2 (DS II), with hydrophobic forces and hydrogen bonding being the dominant intermolecular forces.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Wei Xu, Yuli Ning, Shiwan Cao, Guanchen Wu, Haomin Sun, Liwen Chai, Shuping Wu, Jingyi Li, Denglin Luo
Summary: The interaction mechanism between bovine serum albumin (BSA) and tannic acid (TA) was investigated using spectroscopic and computational approaches, and validated by circular dichroism (CD), differential scanning calorimetry (DSC), and molecular docking techniques. The fluorescence spectra and molecular docking results indicated that TA bound to BSA and caused static quenching at a single binding site. The interaction between BSA and TA was dose-dependent. Thermodynamic analysis showed that hydrophobic forces played a dominant role in the BSA-TA interaction. The stability of the BSA-TA complex was enhanced, as evidenced by changes in secondary structure and increased melting temperature and enthalpy.
Article
Biochemistry & Molecular Biology
Zhe-Ying Hu, Wan-Jun Wang, Lu Hu, Jie-Hua Shi, Shao-Liang Jiang
Summary: Dacomitinib, a tyrosine kinase inhibitor, was found to quench the endogenous fluorescence of bovine serum albumin (BSA) through static quenching. It preferentially inserted into the hydrophobic cavity of the BSA subdomain IA (site III), forming a 1:1 DAC-BSA complex. DAC had a higher affinity for BSA, and non-radiative energy transfer occurred between them. Hydrogen bonds, van der Waals forces, and hydrophobic forces played a significant role in the insertion of DAC into the hydrophobic cavity of BSA. DAC affected the secondary structure of BSA, leading to a slight decrease in the alpha-helix content. The microenvironment around tyrosine residues was affected by the DAC-BSA combination, while the microenvironment around tryptophan residues remained unaffected. Molecular docking and molecular dynamics simulation confirmed the insertion of DAC into site III of BSA, with hydrogen energy and van der Waals energy contributing to the stability of the DAC-BSA complex. The influence of metal ions on the system's affinity was also explored.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Xin Qi, Duoxia Xu, Jinjin Zhu, Shaojia Wang, Jingwei Peng, Wei Gao, Yanping Cao
Summary: The interaction between lutein dipalmitate and BSA was found to be static with a binding stoichiometry of 1:1. Thermodynamic study and molecular docking confirmed that lutein dipalmitate spontaneously bound to BSA through hydrogen bonds, van der Waals forces, and hydrophobic interactions. The addition of lutein dipalmitate led to a decrease in the alpha-helix content of BSA, as observed through CD analysis.
FOOD HYDROCOLLOIDS
(2021)
Article
Multidisciplinary Sciences
Ashima Thakur, Jayant Patwa, Suyash Pant, Abha Sharma, S. J. S. Flora
Summary: The study investigated the interaction between MiADMSA and BSA, finding that MiADMSA can influence the conformation of BSA, and the interaction is spontaneous, endothermic, and involves hydrophobic forces. Experimental and computational studies demonstrated the effective binding of MiADMSA with BSA, essential for drug transportation and elimination from the body.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Ye Li, Hongrui Liu, Chunyu Mu, Jiali Gu, Chun Li
Summary: This study investigated the interaction mechanism between ethoxyquin (EQ) and transporter protein before and after beta-cyclodextrin (beta-CD) encapsulation. The results showed that EQ formed complexes with bovine serum albumin (BSA) and affected its structure and environment. However, encapsulation in beta-CD reduced the binding ability of EQ to BSA and prevented adverse effects on BSA conformation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Applied
Hui Zhang, Yanzhen Zhang, Yongqi Huang, Ling Wu, Qianwan Guo, Qi Wang, Li Liang, Katsuyoshi Nishinari, Meng Zhao
Summary: The study revealed the weak interaction between COS2-6 and BSA, primarily stabilized by electrostatic and hydrophobic forces, providing important insights into the potential of COS in food applications.
Article
Chemistry, Multidisciplinary
Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon, Kamaldeep Paul
Article
Chemistry, Medicinal
Iqubal Singh, Richa Rani, Vijay Luxami, Kamaldeep Paul
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Organic
Mohamad Yusuf, Shehneela Nisa, Kamaldeep Paul
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Iqubal Singh, Vijay Luxami, Kamaldeep Paul
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Dharmender Sharma, Jerry P. Jasinski, Victoria A. Smolinski, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma
INORGANICA CHIMICA ACTA
(2020)
Article
Multidisciplinary Sciences
Iqubal Singh, Vijay Luxami, Kamaldeep Paul
SCIENTIFIC REPORTS
(2020)
Article
Spectroscopy
Iqubal Singh, Vijay Luxami, Kamaldeep Paul
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Spectroscopy
Gulshan Kumar, Iqubal Singh, Richa Goel, Kamaldeep Paul, Vijay Luxami
Summary: The optical probe synthesized shows potential as a sensor for Al3+ and F- ions, exhibiting excited state intramolecular proton transfer and charge transfer. It demonstrated color changes and emission enhancements upon the detection of these ions, with high sensitivity and reliability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Organic
Iqubal Singh, Vijay Luxami, Kamaldeep Paul
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)