期刊
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
卷 89, 期 2, 页码 230-235出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363219020105
关键词
hydrazone; stability constant; rate constant; pyridoxal-5-phosphate; DNA
资金
- Ministry of Science and Higher Education of Russian Federation [4.7305.2017/8.9]
- Russian Foundation for Basic Research [16-33-60017]
- Grant Council of the President of Russian Federation [14.Z56.18.877-MK]
(5-Hydroxy-6-methyl-4-{(E)-[2-oxo-2-(pyrazin-2-yl)ethyl]hydrazinylidenemethyl}pyridin-3-yl)- methyl phosphate has been synthesized via the interaction of pyridoxal-5-phosphate and pyrazin-2- carbohydrazide. Its stability constants in an aqueous solution at pH = 1.9, 6.6, 7.0, and 7.4 have been determined. The kinetics of formation and hydrolysis of the hydrazone has been studied, and rate constants of the direct and reverse reactions have been calculated from the electronic absorption spectroscopy data. The interaction of the obtained hydrazone and its Cu(II) complex with calf thymus DNA has been investigated.
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