期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 9, 页码 6123-6130出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03463
关键词
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资金
- William K. Warren Family and Foundation
- Chair in Medicine
Herein, we report an efficient and operationally simple synthesis of 6,7-dihydro-5H-pyrrolo[2,3-c]pyridazines and 6,7-dihydro-5H-pyrrolo[2,3-b]pyrazines via a tandem hydroamination-SNAr sequence that makes use of mild reagents under catalyst-free conditions in moderate to high yields. This chemistry expands the known scope of pyridazine/pyrazine chemistry and can be applied toward the synthesis of novel drug-like molecules with favorable bioactivity and pharmacokinetic properties.
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