期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 3, 页码 524-528出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.12.025
关键词
Pyrazine; Petasis reaction; Antituberculosis activity; Antifungal activity; Tuberculosis
资金
- Ural Branch of the Russian Academy of Sciences [13-3-019-UMA]
- Russian Foundation for Basic Research [13-03-96049- r_ural_a, 13-03-90606-Arm_a, 14-03-01017 A, 14-03-31040-mol_a]
- Council on Grants at the President of the Russian Federation (Program of State Support for Leading Scientific Schools of the Russian Federation and Young Scientists) [MK-3939.2014.3]
The Petasis reaction of 6-hydroxy adducts of 1-alkyl-2,3-dicyano-5-arylpyrazinium salts with trans-styrylboronic acids proved to proceed smoothly at room temperature to give the corresponding 5-(hetero)aryl-6-styryl substituted 1,6-dihydropyrazine derivatives. Also it has been found that C(6) unsubstituted 1,6-dihydro- or 1,4,5,6-tetrahydropyrazine derivatives can be easy prepared in high yields from the corresponding pyrazinium salts by reduction with triethylsilane. All synthesized compounds were screened in vitro for their antifungal activities against seven pathogenic fungal strains and antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, avium, terrae and multi-drug-resistant strains isolated from tuberculosis patients in the Ural region (Russia). (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据