An efficient synthesis of spiroacridinone derivatives from the facile reaction of isatins, dimedone, and 5‐aminoindazole (6‐aminoindazole or 5‐aminoindole)

Isatins 3-C annulation vs ring-opening: Two different pathways for synthesis of spiro compounds via multicomponent reactions

(2019) Qingqing Niu et al.   TETRAHEDRON LETTERS

Self [3 + 4] Cycloadditions of Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipole with N-(o-Chloromethyl)aryl Amides

(2018) Qiaomei Jin et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of spirooxindoles bearing 2,3-(or 2,5-)dihydrothiophene-2-thione moiety via [3+2] annulation of carbon disulfide with Morita-Baylis-Hillman carbonates of isatins

(2018) Beom Kyu Min et al.   TETRAHEDRON LETTERS

Cs x H 3-x PW 12 O 40 nanoparticles dispersed in the porous network of Zr-pillared α-zirconium phosphate as efficient heterogeneous catalyst for synthesis of spirooxindoles

(2018) Sagnika Pradhan et al.   Molecular Catalysis

An efficient in situ reduction and cyclization reaction for synthesis of spiro compound derivatives in Fe-H2 O-AcOH medium from nitro compounds

(2018) Hui Xu et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[ c ]acridine derivatives as new c- KIT promoter G-quadruplex binding ligands

(2017) Qian-Liang Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Green synthesis of novel spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,3′(7′H)- dione, spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3′-indoline]-2′,3-dione, and spiro[benzo [h]pyrazolo[3,4-b]quinoline-7,3′-indoline]-2′,8(5H)-dione derivatives in aqueous medium

(2017) Zhansheng Wang et al.   TETRAHEDRON

Availability prediction method for EGNOS

(2016) Wei Zhi et al.   GPS SOLUTIONS

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives

(2015) Islavathu Hatti et al.   MEDICINAL CHEMISTRY RESEARCH

Indium(III) Chloride-Catalyzed Isocyanide Insertion Reaction to Construct Complex Spirooxindole

(2015) Yaming Tian et al.   ORGANIC LETTERS

Tertiary-Amine-Catalyzed Asymmetric [3+2] Annulations of Morita–Baylis–Hillman Carbonates of Isatins with Nitroolefins to Construct Spirooxindoles

(2015) Ying-Chun Chen et al.   SYNTHESIS-STUTTGART

An Efficient Synthesis of Pyrroline-Fused Acridine Derivatives Catalyzed by Silica Sulfuric Acid

(2014) Ming-Hua Hu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives

(2014) Takao Saito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cooperative N-heterocyclic carbene (NHC)–Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

(2014) Yu Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

Synthesis and characterization of oxadisilole-fused acridines, dioxatrisilole-fused acridines and benzo[b]acridines

(2014) Jie Zhang et al.   TETRAHEDRON

Domino synthesis of fused hexacyclic imidazoquinolinoacridinones catalyzed by CuI/l-proline

(2014) Chao Li et al.   TETRAHEDRON

New series of acridines and phenanthrolines: synthesis and characterization

(2014) Amel Souibgui et al.   TETRAHEDRON

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

An Efficient Synthesis of Clopenta[b]pyrazolo[4,3-f]quinolin-9(3H)-one Derivatives by Three-component Reaction in Ionic Liquids

(2013) Mei-Mei Zhang et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Modular Access to 9,9-Spirobifluorenes by Oxidative Coupling Using Molybdenum Pentachloride

(2013) Siegfried Waldvogel et al.   SYNTHESIS-STUTTGART

Core Scaffold-Inspired Concise Synthesis of Chiral Spirooxindole-Pyranopyrimidines with Broad-Spectrum Anticancer Potency

(2012) Xianxing Jiang et al.   ADVANCED SYNTHESIS & CATALYSIS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity

(2012) Gangaru Bhaskar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Acridines and Persubstituted Phenols from Cyclobutenones and Active Methylene Ketones

(2012) Xiao-Dan Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tertiary Amine-Catalyzed Chemoselective and Asymmetric [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates of Isatins with Propargyl Sulfones

(2011) Jing Peng et al.   ORGANIC LETTERS

A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions

(2010) Feng Shi et al.   MOLECULAR DIVERSITY

Microwave-assisted Synthesis of Pyrazolo[4,3-f]quinolin-7-one Derivatives via Multi-component Reactions

(2009) Juhua Peng et al.   CHINESE JOURNAL OF CHEMISTRY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage

(2008) Naval Kapuriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Multimeric Quinacrine Conjugate as a Potential Inhibitor of Alzheimer's β-Amyloid Fibril Formation

(2008) Gunnar T. Dolphin et al.   CHEMBIOCHEM

Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II

(2008) Lisa M. Oppegard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acridine/acridone: a simple scaffold with a wide range of application in oncology

(2008) Philippe Belmont et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design, Synthesis, and Structure–Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents

(2008) Caterina Fattorusso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives

(2008) Nilav A. Patel et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Amphiphilic Helical Peptides Containing Two Acridine Moieties Display Picomolar Affinity toward HIV-1 RRE and TAR

(2007) Yeongran Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acridine-Based Agents with Topoisomerase II Activity Inhibit Pancreatic Cancer Cell Proliferation and Induce Apoptosis

(2007) John R. Goodell et al.   JOURNAL OF MEDICINAL CHEMISTRY