期刊
TETRAHEDRON
卷 74, 期 51, 页码 7351-7357出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.10.071
关键词
Tandem reaction; Heterocyclic compounds synthesis; By-product-promoted; Reactivity; Hydrogen bromide; Chemoselectivity
资金
- China Postdoctoral Science Foundation [2017M612433]
- National Natural Science Foundation of China [21173089, 21373093]
Oxazoles and pyrazines are fundamental heterocycles that widely found in natural products or drugs. In this work, a selective strategy for oxazoles and pyrazines synthesis using alpha-bromo-1-phenylethanone and ammonium acetate as starting materials was reported. This methodology features mild reaction conditions, readily accessible starting materials and good chemoselectivity. Mechanistic study indicates that this reaction involves a by-product-promoted (BPP) process for the formation of oxazole, that is, the in-situ formed hydrogen bromide (HBr) during the reaction promotes the whole tandem process. (C) 2018 Elsevier Ltd. All rights reserved.
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